—Due to the complexity of Pediatric Emergency Department, health care management has attracted the attention of many researches which has led to intensive research in agent technology. Multi-agent systems seem to be an effective approach to design complex distributed applications. As the structure of hospitals is divided into several autonomous and ancillary units, we propose a new approach integrating jointly agent-based modeling and optimization tools. In this context, mobile agent paradigm is also very efficient once used through an optimization approach. In this paper, we suggest a three-level agent-based architecture to solve a distributed scheduling problem for resources allocation during patient journey. Our interest is minimizing the waiting time of patients to improve the quality of care process management as well as optimizing resources allocation. This contribution is included in the project ANR HOST (ANR-11-TecSan-010).