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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
131
Publications avec texte intégral
Open Access
52 %
Mots clés
Intermediate filament
Alternative splicing
ARN
Humans
Astrocytes
Transcriptomics
Exercise
ACETYLCHOLINESTERASE
Male
Dilated cardiomyopathy
Mouse models
Maximal force
Mice
Brain
Myotonic Dystrophy Type 1
GSK3
Antisense oligonucleotides
CONGENITAL MYATHENIC SYNDROME
Glial cells
Cell culture model
Oligodendrocyte
Hypoxia
Antisense oligonucleotide
Glutamate
DMSXL mice
GABA
Acetylcholinesterase knockout mouse
Brain dysfunction
Cytoskeleton
KNOCKOUT MICE
Myotonic dystrophy
PCR
RNA biology
Transgenic mouse
RNA splicing
Cell model
CMS
Astrocyte
Aging
MBNL
Animals
Myotonic dystrophy type 1
DMPK
AAV
Myotonic Dystrophy
CTG repeat instability
Neuron
Long read sequencing
Quantitative microdialysis
CRISPR/Cas9
PacBio
Autophagy
Glucocorticoids
Gene therapy
Heart failure
Muscular dystrophy
Central nervous system
CTG repeat contractions
Transgenic mouse model
Muscle
Dystrophin
Therapy
Trinucleotide repeat expansion
Knockout
Myotonic dystrophy mouse models
Cell penetrating peptide
Oligodendrocytes
Gene editing
Myostatin
Fibrosis
Motoneuron
DM1
Acetylcholinesterase deficiency
Gene Therapy
Duchenne muscular dystrophy
Exercice
Skeletal muscle
Myelin
Genotype phenotype correlation
CTG repeats
Thérapie génique
Acute coronary syndrome
In vivo
BIOLOGIE MOLECULAIRE
Dystrophie Myotonique
Mouse model
Heart
Dynamin 2
Glucocorticoid-receptor
Desmin
Centronuclear myopathy
Trinucleotide Repeat Expansion
Myotonic Dystrophy type 1
RNA interference
Diaphragm
Dystrophie myotonique
CRISPRi
Lc3
Expression
Cardiac muscle