Tracing past human male movements in northern/eastern Africa and Western eurasia: new clues from y-chromosomal haplogroups E-M78 and J-M12.
Fulvio Cruciani
(1)
,
Roberta La Fratta
(1)
,
Beniamino Trombetta
(1)
,
Piero Santolamazza
(1)
,
Daniele Sellitto
(2)
,
Eliane Beraud Colomb
(3)
,
Jean-Michel Dugoujon
(4)
,
Federica Crivellaro
(1)
,
Tamara Benincasa
(5)
,
Roberto Pascone
(6)
,
Pedro Moral
(7)
,
Elisabeth Watson
(8)
,
Bela Melegh
(9)
,
Guido Barbujani
(10)
,
Silvia Fuselli
(10)
,
Guiseppe Vona
(11)
,
Boris Zagradisnik
(12)
,
Guenter Assum
(13)
,
Andrey I. Kozlov
(14)
,
Radim Brdicka
(15)
,
Georgi D. Efremov
(16)
,
Alfredo Coppa
(17)
,
Andrea Novelletto
(18)
,
Rosaria Scozzari
(1)
1
Dipartimento di Genetica e Biologia Molecolare
2 CNR | IBPM - CNR Istituto di Biologia e Patologia Molecolari [Roma]
3 Laboratoire d'Immunologie
4 LA - Laboratoire d'Anthropobiologie
5 Dipartimento di Biologia Cellulare
6 Dipartimento di Scienze Ginecologiche Perinatologia e Puericultura
7 Departament de Biologia Animal
8 NRM - Swedish Museum of Natural History
9 Department of Medical Genetics and Child Development
10 Dipartimento di Biologia
11 Dipartimento di Biologia Sperimentale
12 Laboratory of Medical Genetics
13 Institut fur Human Genetic
14 ArctAn C Innovative Laboratory
15 Institute for Haematology and Blood Transfusion
16 Research Center for Genetic Engineering and Biotechnology
17 Dipartimento di Biologia Animale e dell'Uomo
18 Dipartimento di Biologia
2 CNR | IBPM - CNR Istituto di Biologia e Patologia Molecolari [Roma]
3 Laboratoire d'Immunologie
4 LA - Laboratoire d'Anthropobiologie
5 Dipartimento di Biologia Cellulare
6 Dipartimento di Scienze Ginecologiche Perinatologia e Puericultura
7 Departament de Biologia Animal
8 NRM - Swedish Museum of Natural History
9 Department of Medical Genetics and Child Development
10 Dipartimento di Biologia
11 Dipartimento di Biologia Sperimentale
12 Laboratory of Medical Genetics
13 Institut fur Human Genetic
14 ArctAn C Innovative Laboratory
15 Institute for Haematology and Blood Transfusion
16 Research Center for Genetic Engineering and Biotechnology
17 Dipartimento di Biologia Animale e dell'Uomo
18 Dipartimento di Biologia
Guido Barbujani
- Fonction : Auteur
- PersonId : 758092
- ORCID : 0000-0001-7854-6669
- IdRef : 074613006
Alfredo Coppa
- Fonction : Auteur
- PersonId : 758093
- ORCID : 0000-0002-7708-2484
Résumé
Detailed population data were obtained on the distribution of novel biallelic markers that finely dissect the human Y-chromosome haplogroup E-M78. Among 6,501 Y chromosomes sampled in 81 human populations worldwide, we found 517 E-M78 chromosomes and assigned them to 10 subhaplogroups. Eleven microsatellite loci were used to further evaluate subhaplogroup internal diversification. The geographic and quantitative analyses of haplogroup and microsatellite diversity is strongly suggestive of a northeastern African origin of E-M78, with a corridor for bidirectional migrations between northeastern and eastern Africa (at least 2 episodes between 23.9-17.3 ky and 18.0-5.9 ky ago), trans-Mediterranean migrations directly from northern Africa to Europe (mainly in the last 13.0 ky), and flow from northeastern Africa to western Asia between 20.0 and 6.8 ky ago. A single clade within E-M78 (E-V13) highlights a range expansion in the Bronze Age of southeastern Europe, which is also detected by haplogroup J-M12. Phylogeography pattern of molecular radiation and coalescence estimates for both haplogroups are similar and reveal that the genetic landscape of this region is, to a large extent, the consequence of a recent population growth in situ rather than the result of a mere flow of western Asian migrants in the early Neolithic. Our results not only provide a refinement of previous evolutionary hypotheses but also well-defined time frames for past human movements both in northern/eastern Africa and western Eurasia.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Tracing past human male movements in northern/eastern Africa and Western eurasia: new clues from y-chromosomal haplogroups E-M78 and J-M12.
|
Résumé |
en
Detailed population data were obtained on the distribution of novel biallelic markers that finely dissect the human Y-chromosome haplogroup E-M78. Among 6,501 Y chromosomes sampled in 81 human populations worldwide, we found 517 E-M78 chromosomes and assigned them to 10 subhaplogroups. Eleven microsatellite loci were used to further evaluate subhaplogroup internal diversification. The geographic and quantitative analyses of haplogroup and microsatellite diversity is strongly suggestive of a northeastern African origin of E-M78, with a corridor for bidirectional migrations between northeastern and eastern Africa (at least 2 episodes between 23.9-17.3 ky and 18.0-5.9 ky ago), trans-Mediterranean migrations directly from northern Africa to Europe (mainly in the last 13.0 ky), and flow from northeastern Africa to western Asia between 20.0 and 6.8 ky ago. A single clade within E-M78 (E-V13) highlights a range expansion in the Bronze Age of southeastern Europe, which is also detected by haplogroup J-M12. Phylogeography pattern of molecular radiation and coalescence estimates for both haplogroups are similar and reveal that the genetic landscape of this region is, to a large extent, the consequence of a recent population growth in situ rather than the result of a mere flow of western Asian migrants in the early Neolithic. Our results not only provide a refinement of previous evolutionary hypotheses but also well-defined time frames for past human movements both in northern/eastern Africa and western Eurasia.
|
Auteur(s) |
Fulvio Cruciani
1
, Roberta La Fratta
1
, Beniamino Trombetta
1
, Piero Santolamazza
1
, Daniele Sellitto
2
, Eliane Beraud Colomb
3
, Jean-Michel Dugoujon
4
, Federica Crivellaro
1
, Tamara Benincasa
5
, Roberto Pascone
6
, Pedro Moral
7
, Elisabeth Watson
8
, Bela Melegh
9
, Guido Barbujani
10
, Silvia Fuselli
10
, Guiseppe Vona
11
, Boris Zagradisnik
12
, Guenter Assum
13
, Andrey I. Kozlov
14
, Radim Brdicka
15
, Georgi D. Efremov
16
, Alfredo Coppa
17
, Andrea Novelletto
18
, Rosaria Scozzari
1
1
Dipartimento di Genetica e Biologia Molecolare
( 37315 )
- Italie
2
CNR | IBPM -
CNR Istituto di Biologia e Patologia Molecolari [Roma]
( 358743 )
- Institute of Molecular Biology and Pathology |
c/o Dip.di Scienze Biochimiche,
presso Università di Roma La Sapienza, Piazzale Aldo Moro 5 - 00185 Roma
- Italie
3
Laboratoire d'Immunologie
( 37326 )
- Marseille
- France
4
LA -
Laboratoire d'Anthropobiologie
( 31348 )
- 37 allées Jules Guesde 31400 Toulouse
- France
5
Dipartimento di Biologia Cellulare
( 37327 )
- Rende
- Italie
6
Dipartimento di Scienze Ginecologiche Perinatologia e Puericultura
( 37328 )
- Rome
- France
7
Departament de Biologia Animal
( 37329 )
- Barcelone
- Espagne
8
NRM -
Swedish Museum of Natural History
( 106899 )
- Frescativägen 40, P.O. Box 50007, 10405 Stockholm
- Suède
9
Department of Medical Genetics and Child Development
( 37332 )
- Pécs
- Hongrie
10
Dipartimento di Biologia
( 37333 )
- Italie
11
Dipartimento di Biologia Sperimentale
( 37334 )
- Italie
12
Laboratory of Medical Genetics
( 37336 )
- Maribor
- Slovénie
13
Institut fur Human Genetic
( 37338 )
- Ulm
- Allemagne
14
ArctAn C Innovative Laboratory
( 37340 )
- Moscou
- Russie
15
Institute for Haematology and Blood Transfusion
( 37339 )
- Prague
- Tchéquie
16
Research Center for Genetic Engineering and Biotechnology
( 37343 )
- Skopje
- Macédoine du Nord
17
Dipartimento di Biologia Animale e dell'Uomo
( 37344 )
- Rome
- Italie
18
Dipartimento di Biologia
( 37345 )
- Rome
- Italie
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Audience |
Internationale
|
Date de publication |
2007
|
Volume |
24
|
Numéro |
6
|
Page/Identifiant |
1300-1311
|
Domaine(s) |
|
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