Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers.
Lluis Quintana-Murci
(1)
,
Hélène Quach
(1)
,
Christine Harmant
(1)
,
Francesca Luca
(1)
,
Blandine Massonnet
(1)
,
Etienne Patin
(1)
,
Lucas Sica
(2)
,
Patrick Mouguiama-Daouda
(3)
,
David Comas
(4)
,
Shay Tzur
(5)
,
Oleg Balanovsky
(6)
,
Kenneth K Kidd
(7)
,
Judith R Kidd
(7)
,
Lolke van Der Veen
(3)
,
Jean-Marie Hombert
(3)
,
Antoine Gessain
(8)
,
Paul Verdu
(5, 9)
,
Alain Froment
(9, 10)
,
Serge Bahuchet
(9)
,
Evelyne Heyer
(9)
,
Jean Dausset
(11)
,
Antonio Salas
(12)
,
Doron M Behar
(5)
1
Prévention et Thérapie Moléculaires des Maladies Infectieuses Humaines
2 CIRMF - Centre International de Recherches Médicales de Franceville
3 DDL - Dynamique Du Langage
4 Unitat de Biologia Evolutiva
5 Molecular Medicine Laboratory
6 Russian Academy of Medical Sciences
7 Department of Genetics
8 Epidémiologie et Physiopathologie des Virus Oncogènes
9 EAE - Eco-Anthropologie et Ethnobiologie
10 ADENTHRO - Adaptations humaines aux environnements tropicaux durant l'Holocène
11 SRHI - UMR_E 05 - Service de Recherche en Hémato-Immunologie
12 UX - Unidade de Xenetica
2 CIRMF - Centre International de Recherches Médicales de Franceville
3 DDL - Dynamique Du Langage
4 Unitat de Biologia Evolutiva
5 Molecular Medicine Laboratory
6 Russian Academy of Medical Sciences
7 Department of Genetics
8 Epidémiologie et Physiopathologie des Virus Oncogènes
9 EAE - Eco-Anthropologie et Ethnobiologie
10 ADENTHRO - Adaptations humaines aux environnements tropicaux durant l'Holocène
11 SRHI - UMR_E 05 - Service de Recherche en Hémato-Immunologie
12 UX - Unidade de Xenetica
Lluis Quintana-Murci
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 754080
- IdHAL : lluis-quintana-murci
- ORCID : 0000-0003-2429-6320
- IdRef : 127109897
Connectez-vous pour contacter l'auteur
Christine Harmant
- Fonction : Auteur
- PersonId : 748763
- IdHAL : christine-harmant
- ORCID : 0000-0003-2949-772X
Etienne Patin
- Fonction : Auteur
- PersonId : 179015
- IdHAL : etienne-patin
- ORCID : 0000-0002-9911-4459
- IdRef : 132614553
Lolke van Der Veen
- Fonction : Auteur
- PersonId : 1257132
- IdHAL : lolke-van-der-veen
- ORCID : 0009-0003-3128-064X
Antoine Gessain
- Fonction : Auteur
- PersonId : 1175803
- ORCID : 0000-0001-6840-4413
- IdRef : 07692193X
Paul Verdu
- Fonction : Auteur
- PersonId : 175682
- IdHAL : paul-verdu
- ORCID : 0000-0001-6828-268X
- IdRef : 139926372
Alain Froment
- Fonction : Auteur
- PersonId : 834755
Evelyne Heyer
- Fonction : Auteur
- PersonId : 177102
- IdHAL : evelyne-heyer
- ORCID : 0000-0002-0266-3196
- IdRef : 070848289
Résumé
Two groups of populations with completely different lifestyles-the Pygmy hunter-gatherers and the Bantu-speaking farmers-coexist in Central Africa. We investigated the origins of these two groups and the interactions between them, by analyzing mtDNA variation in 1,404 individuals from 20 farming populations and 9 Pygmy populations from Central Africa, with the aim of shedding light on one of the most fascinating cultural transitions in human evolution (the transition from hunting and gathering to agriculture). Our data indicate that this region was colonized gradually, with an initial L1c-rich ancestral population ultimately giving rise to current-day farmers, who display various L1c clades, and to Pygmies, in whom L1c1a is the only surviving clade. Detailed phylogenetic analysis of complete mtDNA sequences for L1c1a showed this clade to be autochthonous to Central Africa, with its most recent branches shared between farmers and Pygmies. Coalescence analyses revealed that these two groups arose through a complex evolutionary process characterized by (i) initial divergence of the ancestors of contemporary Pygmies from an ancestral Central African population no more than approximately 70,000 years ago, (ii) a period of isolation between the two groups, accounting for their phenotypic differences, (iii) long-standing asymmetric maternal gene flow from Pygmies to the ancestors of the farming populations, beginning no more than approximately 40,000 years ago and persisting until a few thousand years ago, and (iv) enrichment of the maternal gene pool of the ancestors of the farming populations by the arrival and/or subsequent demographic expansion of L0a, L2, and L3 carriers.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers.
|
Résumé |
en
Two groups of populations with completely different lifestyles-the Pygmy hunter-gatherers and the Bantu-speaking farmers-coexist in Central Africa. We investigated the origins of these two groups and the interactions between them, by analyzing mtDNA variation in 1,404 individuals from 20 farming populations and 9 Pygmy populations from Central Africa, with the aim of shedding light on one of the most fascinating cultural transitions in human evolution (the transition from hunting and gathering to agriculture). Our data indicate that this region was colonized gradually, with an initial L1c-rich ancestral population ultimately giving rise to current-day farmers, who display various L1c clades, and to Pygmies, in whom L1c1a is the only surviving clade. Detailed phylogenetic analysis of complete mtDNA sequences for L1c1a showed this clade to be autochthonous to Central Africa, with its most recent branches shared between farmers and Pygmies. Coalescence analyses revealed that these two groups arose through a complex evolutionary process characterized by (i) initial divergence of the ancestors of contemporary Pygmies from an ancestral Central African population no more than approximately 70,000 years ago, (ii) a period of isolation between the two groups, accounting for their phenotypic differences, (iii) long-standing asymmetric maternal gene flow from Pygmies to the ancestors of the farming populations, beginning no more than approximately 40,000 years ago and persisting until a few thousand years ago, and (iv) enrichment of the maternal gene pool of the ancestors of the farming populations by the arrival and/or subsequent demographic expansion of L0a, L2, and L3 carriers.
|
Auteur(s) |
Lluis Quintana-Murci
1
, Hélène Quach
1
, Christine Harmant
1
, Francesca Luca
1
, Blandine Massonnet
1
, Etienne Patin
1
, Lucas Sica
2
, Patrick Mouguiama-Daouda
3
, David Comas
4
, Shay Tzur
5
, Oleg Balanovsky
6
, Kenneth K Kidd
7
, Judith R Kidd
7
, Lolke van Der Veen
3
, Jean-Marie Hombert
3
, Antoine Gessain
8
, Paul Verdu
5, 9
, Alain Froment
9, 10
, Serge Bahuchet
9
, Evelyne Heyer
9
, Jean Dausset
11
, Antonio Salas
12
, Doron M Behar
5
1
Prévention et Thérapie Moléculaires des Maladies Infectieuses Humaines
( 35813 )
- 25 rue du Docteur Roux F-75724 Paris Cedex 15
- France
2
CIRMF -
Centre International de Recherches Médicales de Franceville
( 51216 )
- Franceville, Gabon
- Gabon
3
DDL -
Dynamique Du Langage
( 740 )
- INSTITUT DES SCIENCES DE L'HOMME 14 Avenue Berthelot 69363 LYON CEDEX 07
- France
4
Unitat de Biologia Evolutiva
( 58006 )
- Unitat de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona
- Espagne
5
Molecular Medicine Laboratory
( 58007 )
- Rambam Health Care Campus, Haifa 31096, Israel
- France
6
Russian Academy of Medical Sciences
( 58008 )
- Russian Academy of Medical Sciences, 109544 Moscow,
- Russie
7
Department of Genetics
( 58009 )
- Yale University School of Medicine, SHM I-353, New Haven, CT 06510
- États-Unis
8
Epidémiologie et Physiopathologie des Virus Oncogènes
( 25155 )
- 25-28 rue du Docteur Roux F-75724 Paris Cedex 15
- France
9
EAE -
Eco-Anthropologie et Ethnobiologie
( 627 )
- Dpt Hommes Natures Sociétés 57 rue Cuvier 75231 PARIS CEDEX 05
- France
10
ADENTHRO -
Adaptations humaines aux environnements tropicaux durant l'Holocène
( 12782 )
- IRD Orléans - 5 rue du Carbone - Technoparc - 45072 Orléans Cedex 2
- France
11
SRHI - UMR_E 05 -
Service de Recherche en Hémato-Immunologie
( 40419 )
- Université Paris Diderot Institut Universitaire d'Hématologie (IUH) Hôpital Saint Louis 1 avenue Claude Vellefaux 75010 Paris
- France
12
UX -
Unidade de Xenetica
( 57101 )
- Espagne
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Audience |
Non spécifiée
|
Date de publication |
2008-02-05
|
Date de publication électronique |
2008-01-23
|
Volume |
105
|
Numéro |
5
|
Page/Identifiant |
1596-601
|
Domaine(s) |
|
Mots-clés (Mesh) |
|
DOI | 10.1073/pnas.0711467105 |
Pubmed Id | 18216239 |
PubMed Central | PMC2234190 |
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