Educational and occupational outcomes of childhood cancer survivors 30 ă years after diagnosis: a French cohort study
Agnès Dumas
(1)
,
Claire Berger
,
Pascal Auquier
(2)
,
Gérard Michel
(3)
,
Brice Fresneau
(4)
,
Rodrigue Setcheou Allodji
,
Nadia Haddy
(1)
,
Carole Rubino
(1)
,
Gilles Vassal
(5, 6)
,
Dominique Valteau-Couanet
(4)
,
Sandrine Thouvenin-Doulet
(7)
,
Léonie Casagranda
(8)
,
Hélène Pacquement
(9)
,
Chiraz El-Fayech
(1)
,
Odile Oberlin
(1, 4)
,
Catherine Guibout
(1)
,
Florent De Vathaire
(6)
1
CESP -
Centre de recherche en épidémiologie et santé des populations
2 SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
3 Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM]
4 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
5 IGR - Institut Gustave Roussy
6 Direction de la recherche clinique [Gustave Roussy]
7 Service d'hématologie pédiatrique
8 Registre des Cancers de l'Enfant de Rhônes-Alpes
9 Institut Curie [Paris]
2 SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
3 Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM]
4 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
5 IGR - Institut Gustave Roussy
6 Direction de la recherche clinique [Gustave Roussy]
7 Service d'hématologie pédiatrique
8 Registre des Cancers de l'Enfant de Rhônes-Alpes
9 Institut Curie [Paris]
Agnès Dumas
- Fonction : Auteur
- PersonId : 4422
- IdHAL : agnes-dumas
- ORCID : 0000-0001-7948-6952
- IdRef : 158640462
Claire Berger
- Fonction : Auteur
- PersonId : 757697
- ORCID : 0000-0001-9875-5150
Pascal Auquier
- Fonction : Auteur
- PersonId : 860193
Brice Fresneau
- Fonction : Auteur
- PersonId : 1199184
- IdHAL : b-fresneau
- ORCID : 0000-0001-7603-7828
Rodrigue Setcheou Allodji
- Fonction : Auteur
Nadia Haddy
- Fonction : Auteur
- PersonId : 758730
- ORCID : 0000-0001-9316-8280
- IdRef : 075520516
Gilles Vassal
- Fonction : Auteur
- PersonId : 757399
- ORCID : 0000-0003-1780-8869
Léonie Casagranda
- Fonction : Auteur
- PersonId : 1237665
- ORCID : 0000-0001-9297-6278
Résumé
Background: Although survival from childhood cancer has increased, ă little is known on the long-term impact of treatment late effects on ă occupational attainment or work ability. ă Methods: A total of 3512 five-year survivors treated before the age of ă 19 years in 10 French cancer centres between 1948 and 2000 were ă identified. Educational level, employment status and occupational class ă of survivors were assessed by a self-reported questionnaire. These ă outcome measures were compared with sex-age rates recorded in the French ă population, using indirect standardisation. Paternal occupational class ă was also considered to control for the role of survivors' socioeconomic ă background on their achievement. Multivariable analyses were conducted ă to explore clinical characteristics associated with the outcomes. ă Results: A total of 2406 survivors responded to the questionnaire and ă survivors aged below 25 years were included in the current analysis. ă Compared with national statistics adjusted on age and sex, male ă survivors were more likely to be college graduates (39.2% vs 30.9% ă expected; P<0.001). This higher achievement was not observed either for ă leukaemia or central nervous system (CNS) tumour survivors. ă Health-related unemployment was higher for survivors of CNS tumour ă (28.1% vs 4.3%; P<0.001) but not for survivors of other diagnoses. ă Survivors of non-CNS childhood cancer had a similar or a higher ă occupational class than expected. ă Conclusions: Survivors treated for CNS tumour or leukaemia, especially ă when treatment included cranial irradiation, might need support ă throughout their lifespan.
Domaines
Santé publique et épidémiologie Economies et finances Psychologie Psychiatrie et santé mentaleFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Educational and occupational outcomes of childhood cancer survivors 30 ă years after diagnosis: a French cohort study
|
Résumé |
en
Background: Although survival from childhood cancer has increased, ă little is known on the long-term impact of treatment late effects on ă occupational attainment or work ability. ă Methods: A total of 3512 five-year survivors treated before the age of ă 19 years in 10 French cancer centres between 1948 and 2000 were ă identified. Educational level, employment status and occupational class ă of survivors were assessed by a self-reported questionnaire. These ă outcome measures were compared with sex-age rates recorded in the French ă population, using indirect standardisation. Paternal occupational class ă was also considered to control for the role of survivors' socioeconomic ă background on their achievement. Multivariable analyses were conducted ă to explore clinical characteristics associated with the outcomes. ă Results: A total of 2406 survivors responded to the questionnaire and ă survivors aged below 25 years were included in the current analysis. ă Compared with national statistics adjusted on age and sex, male ă survivors were more likely to be college graduates (39.2% vs 30.9% ă expected; P<0.001). This higher achievement was not observed either for ă leukaemia or central nervous system (CNS) tumour survivors. ă Health-related unemployment was higher for survivors of CNS tumour ă (28.1% vs 4.3%; P<0.001) but not for survivors of other diagnoses. ă Survivors of non-CNS childhood cancer had a similar or a higher ă occupational class than expected. ă Conclusions: Survivors treated for CNS tumour or leukaemia, especially ă when treatment included cranial irradiation, might need support ă throughout their lifespan.
|
Auteur(s) |
Agnès Dumas
1
, Claire Berger
, Pascal Auquier
2
, Gérard Michel
3
, Brice Fresneau
4
, Rodrigue Setcheou Allodji
, Nadia Haddy
1
, Carole Rubino
1
, Gilles Vassal
5, 6
, Dominique Valteau-Couanet
4
, Sandrine Thouvenin-Doulet
7
, Léonie Casagranda
8
, Hélène Pacquement
9
, Chiraz El-Fayech
1
, Odile Oberlin
1, 4
, Catherine Guibout
1
, Florent De Vathaire
6
1
CESP -
Centre de recherche en épidémiologie et santé des populations
( 106188 )
- 16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
- France
2
SPMC -
Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
( 233198 )
- Laboratoire de Santé Publique - 27 bd Jean Moulin 13385 Marseille 05
- France
3
Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM]
( 458700 )
- 264 Rue Saint-Pierre, 13385 Marseille
- France
4
Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
( 456891 )
- France
5
IGR -
Institut Gustave Roussy
( 156104 )
- 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France
- France
6
Direction de la recherche clinique [Gustave Roussy]
( 456659 )
- Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France
- France
7
Service d'hématologie pédiatrique
( 439024 )
- France
8
Registre des Cancers de l'Enfant de Rhônes-Alpes
( 32211 )
- Saint-Etienne
- France
9
Institut Curie [Paris]
( 301888 )
- 26 rue d'Ulm - 75248 Paris
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2016-04
|
Volume |
114
|
Numéro |
9
|
Page/Identifiant |
1060-1068
|
Domaine(s) |
|
Mots-clés |
en
Quality
|
DOI | 10.1038/bjc.2016.62 |
PubMed Central | PMC4984908 |
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