Incidence and severity of crucial late effects after allogeneic HSCT for ă malignancy under the age of 3 years: TBI is what really matters - HAL-SHS - Sciences de l'Homme et de la Société Accéder directement au contenu
Article Dans Une Revue Bone Marrow Transplantation Année : 2016

Incidence and severity of crucial late effects after allogeneic HSCT for ă malignancy under the age of 3 years: TBI is what really matters

D. Bresters
  • Fonction : Auteur
A. Lawitschka
  • Fonction : Auteur
C. Cugno
  • Fonction : Auteur
U. Poetschger
  • Fonction : Auteur
A. Dalissier
  • Fonction : Auteur
G. Michel
  • Fonction : Auteur
K. Vettenranta
  • Fonction : Auteur
M. Sundin
  • Fonction : Auteur
A. Al-Seraihy
  • Fonction : Auteur
M. Faraci
  • Fonction : Auteur
A. B. Versluys
  • Fonction : Auteur
A. Jenkins
P. Lutz
  • Fonction : Auteur
B. Gibson
  • Fonction : Auteur
A. Leiper
  • Fonction : Auteur
M. A. Diaz
  • Fonction : Auteur
P. J. Shaw
  • Fonction : Auteur
R. Skinner
  • Fonction : Auteur
T. A. O'Brien
  • Fonction : Auteur
N. Salooja
  • Fonction : Auteur
P. Bader
  • Fonction : Auteur
C. Peters
  • Fonction : Auteur

Résumé

Younger children are considered to be more vulnerable to late effects ă (LE), which prompted us to study LE in patients after haematopoietic ă stem cell transplantation (HSCT) for a haematological malignancy before ă the age of 3. In this multicentre EBMT study, cumulative incidence (CI) ă and severity of endocrine LE, central nervous system complications and ă secondary malignancies at 5, 10, 15 and 20 years of follow-up were ă assessed. Risk factors (RF) like gender, diagnosis, age at and year of ă HSCT, TBI-or chemo-conditioning and GVHD were analysed. CI of any LE was ă 0.30, 0.52, 0.66 and 0.72 at 5, 10, 15 and 20 years after HSCT, ă respectively. In 25% of the patients, LE were severe at a median ă follow-up of 10.4 years. In multivariate analysis, only TBI was a RF for ă having any LE and for thyroid dysfunction and growth disturbance. Female ă gender was a RF for delayed pubertal development. Some more insight ă could be gained by descriptive analysis regarding the role of TBI and ă GVHD on the severity of LE. Although only five selected LE have been ă studied and median follow-up is relatively short, the incidence and ă severity of these LE are considerable but not different from what has ă been found in older children and TBI is the main RF.

Dates et versions

hal-01482662 , version 1 (03-03-2017)

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Citer

D. Bresters, A. Lawitschka, C. Cugno, U. Poetschger, A. Dalissier, et al.. Incidence and severity of crucial late effects after allogeneic HSCT for ă malignancy under the age of 3 years: TBI is what really matters. Bone Marrow Transplantation, 2016, 51 (11), pp.1482-1489. ⟨10.1038/bmt.2016.139⟩. ⟨hal-01482662⟩
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