Risk profile, quality of life and care of patients with moderate and advanced CKD : The French CKD-REIN Cohort Study
Benedicte Stengel
(1)
,
Marie Metzger
(1)
,
Christian Combe
(2, 3)
,
Denis Jacquelinet
(1, 4)
,
Serge Briançon
(5, 6)
,
Carole Ayav
(7, 5)
,
Denis Fouque
(8)
,
Maurice Laville
(8)
,
Luc Frimat
(6, 9)
,
Christophe Pascal
(10)
,
Yves-Edouard Herpe
(11, 12)
,
Pascal Morel
(13)
,
Jean-François Deleuze
(14)
,
Joost P. Schanstra
(15, 16)
,
Céline Lange
(1, 4)
,
Karine Legrand
(6, 5)
,
Elodie Speyer
(1)
,
Sophie Liabeuf
(1, 12, 17, 18)
,
Bruce Robinson
(19)
,
Ziad Massy
(1, 20)
1
CESP -
Centre de recherche en épidémiologie et santé des populations
2 Service de Néphrologie-transplantation-dialyse [Bordeaux]
3 BIOTIS - Bioingénierie tissulaire
4 Agence de la biomédecine [Saint-Denis la Plaine]
5 CIC - Centre d'investigation clinique [Nancy]
6 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
7 Nephrolor - Réseau Lorrain de prise en charge de l’insuffisance rénale chronique : Réseau NEPHROLOR
8 Service de néphrologie
9 Service de Néphrologie [CHRU Nancy]
10 UJML - Université Jean Moulin - Lyon 3
11 Biobanque de Picardie [CHU Amiens - Hôpital Sud]
12 CHU Amiens-Picardie
13 EFS BFC - Etablissement français du sang [Bourgogne-Franche-Comté]
14 CNRGH - Centre National de Recherche en Génomique Humaine
15 Equipe 7 Inserm U1048
16 UT3 - Université Toulouse III - Paul Sabatier
17 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
18 CKD REIN - Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie
19 Arbor Research Collaborative for Health
20 Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]
2 Service de Néphrologie-transplantation-dialyse [Bordeaux]
3 BIOTIS - Bioingénierie tissulaire
4 Agence de la biomédecine [Saint-Denis la Plaine]
5 CIC - Centre d'investigation clinique [Nancy]
6 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
7 Nephrolor - Réseau Lorrain de prise en charge de l’insuffisance rénale chronique : Réseau NEPHROLOR
8 Service de néphrologie
9 Service de Néphrologie [CHRU Nancy]
10 UJML - Université Jean Moulin - Lyon 3
11 Biobanque de Picardie [CHU Amiens - Hôpital Sud]
12 CHU Amiens-Picardie
13 EFS BFC - Etablissement français du sang [Bourgogne-Franche-Comté]
14 CNRGH - Centre National de Recherche en Génomique Humaine
15 Equipe 7 Inserm U1048
16 UT3 - Université Toulouse III - Paul Sabatier
17 MP3CV - Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
18 CKD REIN - Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie
19 Arbor Research Collaborative for Health
20 Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]
Benedicte Stengel
- Fonction : Auteur
- PersonId : 888936
- ORCID : 0000-0001-9025-5178
Christian Combe
- Fonction : Auteur
- PersonId : 756127
- ORCID : 0000-0002-0360-573X
- IdRef : 058708871
Serge Briançon
- Fonction : Auteur
- PersonId : 919110
Denis Fouque
- Fonction : Auteur
- PersonId : 761251
- ORCID : 0000-0002-9707-7199
- IdRef : 068884958
Luc Frimat
- Fonction : Auteur
- PersonId : 919108
Christophe Pascal
- Fonction : Auteur
- PersonId : 20106
- IdHAL : christophe-pascal
- ORCID : 0000-0002-4667-644X
- IdRef : 083503439
Pascal Morel
- Fonction : Auteur
- PersonId : 773001
- ORCID : 0000-0002-8916-7717
Jean-François Deleuze
- Fonction : Auteur
- PersonId : 1015006
Joost P. Schanstra
- Fonction : Auteur
- PersonId : 837350
- ORCID : 0000-0002-7471-372X
- IdRef : 076749304
Karine Legrand
- Fonction : Auteur
- PersonId : 739566
- IdHAL : karine-legrand
- ORCID : 0000-0003-0209-4576
- IdRef : 203620860
Elodie Speyer
- Fonction : Auteur
- PersonId : 1338417
- IdHAL : elodiespeyer
Sophie Liabeuf
- Fonction : Auteur
- PersonId : 750529
- IdHAL : sophieliabeuf
- ORCID : 0000-0001-5384-9006
- IdRef : 081054882
Ziad Massy
- Fonction : Auteur
- PersonId : 1003368
- ORCID : 0000-0001-5771-5996
Résumé
Background: The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study was designed to investigate the determinants of prognosis and care of patients referred to nephrologists with moderate and advanced chronic kidney disease (CKD). We examined their baseline risk profile and experience.
Methods: We collected bioclinical and patient-reported information from 3033 outpatients with CKD and estimated glomerular filtration rates (eGFRs) of 15-60 mL/min/1.73 m2 treated at 40 nationally representative public and private facilities.
Results: The patients' median age was 69 (60-76) years, 65% were men, their mean eGFR was 33 mL/min/1.73 m2, 43% had diabetes, 24% had a history of acute kidney injury (AKI) and 57% had uncontrolled blood pressure (BP; >140/90 mmHg). Men had worse risk profiles than women and were more likely to be past or current smokers (73% versus 34%) and have cardiovascular disease (59% versus 42%), albuminuria >30 mg/mmol (or proteinuria > 50) (40% versus 30%) (all P < 0.001) and a higher median risk of end-stage renal disease within 5 years, predicted by the kidney failure risk equation {12% [interquartile range (IQR) 3-37%] versus 9% [3-31%], P = 0.008}. During the previous year, 60% of patients reported one-to-two nephrologist visits and four or more general practitioner visits; only 25% saw a dietician and 75% were prescribed five or more medications daily. Physical and mental quality of life (QoL) were poor, with scores <50/100.
Conclusions: The CKD-REIN study highlights high-risk profiles of cohort members and identifies several priorities, including improving BP control and dietary counselling and increasing doctors' awareness of AKI, polypharmacy and QoL.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Risk profile, quality of life and care of patients with moderate and advanced CKD : The French CKD-REIN Cohort Study
|
Résumé |
en
Background: The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study was designed to investigate the determinants of prognosis and care of patients referred to nephrologists with moderate and advanced chronic kidney disease (CKD). We examined their baseline risk profile and experience.
Methods: We collected bioclinical and patient-reported information from 3033 outpatients with CKD and estimated glomerular filtration rates (eGFRs) of 15-60 mL/min/1.73 m2 treated at 40 nationally representative public and private facilities.
Results: The patients' median age was 69 (60-76) years, 65% were men, their mean eGFR was 33 mL/min/1.73 m2, 43% had diabetes, 24% had a history of acute kidney injury (AKI) and 57% had uncontrolled blood pressure (BP; >140/90 mmHg). Men had worse risk profiles than women and were more likely to be past or current smokers (73% versus 34%) and have cardiovascular disease (59% versus 42%), albuminuria >30 mg/mmol (or proteinuria > 50) (40% versus 30%) (all P < 0.001) and a higher median risk of end-stage renal disease within 5 years, predicted by the kidney failure risk equation {12% [interquartile range (IQR) 3-37%] versus 9% [3-31%], P = 0.008}. During the previous year, 60% of patients reported one-to-two nephrologist visits and four or more general practitioner visits; only 25% saw a dietician and 75% were prescribed five or more medications daily. Physical and mental quality of life (QoL) were poor, with scores <50/100.
Conclusions: The CKD-REIN study highlights high-risk profiles of cohort members and identifies several priorities, including improving BP control and dietary counselling and increasing doctors' awareness of AKI, polypharmacy and QoL.
|
Auteur(s) |
Benedicte Stengel
1
, Marie Metzger
1
, Christian Combe
2, 3
, Denis Jacquelinet
1, 4
, Serge Briançon
5, 6
, Carole Ayav
7, 5
, Denis Fouque
8
, Maurice Laville
8
, Luc Frimat
6, 9
, Christophe Pascal
10
, Yves-Edouard Herpe
11, 12
, Pascal Morel
13
, Jean-François Deleuze
14
, Joost P. Schanstra
15, 16
, Céline Lange
1, 4
, Karine Legrand
6, 5
, Elodie Speyer
1
, Sophie Liabeuf
1, 12, 17, 18
, Bruce Robinson
19
, Ziad Massy
1, 20
1
CESP -
Centre de recherche en épidémiologie et santé des populations
( 106188 )
- 16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
- France
2
Service de Néphrologie-transplantation-dialyse [Bordeaux]
( 410000 )
- pl Amélie Raba Léon
33076 BORDEAUX CEDEX
- France
3
BIOTIS -
Bioingénierie tissulaire
( 139716 )
- 146, rue Léo Saignat 33076 Bordeaux cedex
- France
4
Agence de la biomédecine [Saint-Denis la Plaine]
( 115378 )
- 1 avenue du stade de France
93212 SAINT-DENIS LA PLAINE Cedex
- France
5
CIC -
Centre d'investigation clinique [Nancy]
( 254924 )
- 4 rue du Morvan - Bâtiment Louis Mathieu - 54500 Vandoeuvre-les-Nancy Cedex
- France
6
APEMAC -
Maladies chroniques, santé perçue, et processus d'adaptation
( 539959 )
- Université de Lorraine, Nancy / Metz
- France
7
Nephrolor -
Réseau Lorrain de prise en charge de l’insuffisance rénale chronique : Réseau NEPHROLOR
( 461133 )
- CHRU de Nancy, Hôpitaux de Brabois, Service de Néphrologie, 54500 Vandoeuvre-lès-Nancy
- France
8
Service de néphrologie
( 95357 )
- France
9
Service de Néphrologie [CHRU Nancy]
( 44280 )
- rue du Morvan - 54511 Vandoeuvre-les-Nancy Cedex
- France
10
UJML -
Université Jean Moulin - Lyon 3
( 118744 )
- 6 cours Albert Thomas - 69008 Lyon
- France
11
Biobanque de Picardie [CHU Amiens - Hôpital Sud]
( 580114 )
- France
12
CHU Amiens-Picardie
( 300535 )
- France
13
EFS BFC -
Etablissement français du sang [Bourgogne-Franche-Comté]
( 439502 )
- 1 Boulevard Fleming 25020 Besançon cedex
- France
14
CNRGH -
Centre National de Recherche en Génomique Humaine
( 557361 )
- Evry
- France
15
Equipe 7 Inserm U1048
( 404173 )
- France
16
UT3 -
Université Toulouse III - Paul Sabatier
( 217752 )
- 118 route de Narbonne - 31062 Toulouse
- France
17
MP3CV -
Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517
( 533000 )
- Université de Picardie Jules Verne - Centre de Recherche Universitaire en Santé (CURS) - CHU Sud - rue Renée Laennec -
80054 Amiens Cedex
- France
18
CKD REIN -
Chronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie
( 1143605 )
- France
19
Arbor Research Collaborative for Health
( 536211 )
- 340 E Huron St # 300, Ann Arbor, MI 48104
- États-Unis
20
Service Néphrologie/Dialyse [AP-HP Ambroise-Paré]
( 253793 )
- 9 Avenue Charles de Gaulle 92100 Boulogne-Billancourt
- France
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Date de publication |
2018-04-09
|
Langue du document |
Anglais
|
Audience |
Internationale
|
Volume |
34
|
Numéro |
2
|
Page/Identifiant |
277-286
|
Domaine(s) |
|
Projet(s) ANR |
|
DOI | 10.1093/ndt/gfy058 |
Pubmed Id | 29635335 |
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