Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome - HAL Accéder directement au contenu
Article dans une revue Journal of Clinical Endocrinology and Metabolism Année : 2010

Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome

Résumé

Stimulation of cortisol secretion through abnormally expressed G protein-coupled receptors (GPCRs) is a frequent feature of ACTH-independent macronodular adrenal hyperplasia (AIMAH). This has opened a pharmacological strategy that targets GPCRs for the treatment of Cushing's syndrome in AIMAH. However, only few drugs are available for the presently described GPCRs.
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hal-02459109, version 1 (29-01-2020)

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Guillaume Assié, Estelle Louiset, Nathalie Sturm, Fernande René-Corail, Lionel Groussin, et al.. Systematic Analysis of G Protein-Coupled Receptor Gene Expression in Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Identifies Novel Targets for Pharmacological Control of Adrenal Cushing’s Syndrome. Journal of Clinical Endocrinology and Metabolism, 2010, 95 (10), pp.E253-E262. ⟨10.1210/jc.2009-2281⟩. ⟨hal-02459109⟩
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