Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
A. Skytthe
(1)
,
S. Valensin
(2)
,
B. Jeune
(1)
,
E. Cevenini
(2)
,
Frédéric Balard
(3, 4)
,
Matthias Beekmann
(5)
,
V. Bezrukov
(6)
,
H. Blanche
(7)
,
L. Bolund
(8, 9)
,
K. Broczek
(10, 11)
,
C. Carru
(12)
,
K. Christensen
(1, 13)
,
L. Christiansen
(1)
,
J. C. Collerton
(14)
,
R. Cotichini
(15)
,
A.J.M. de Craen
(16)
,
S. Dato
(17)
,
K. Davies
(14)
,
C. de Benedictis
(17)
,
L. Deiana
(12)
,
F. Flachsbart
(18)
,
J. Gampe
(19)
,
C. Gilbault
(20)
,
E.S. Gonos
(21)
,
E. Haimes
(14)
,
A. Hervonen
(22)
,
M.A. Hurme
(22)
,
D. Janiszewska
(10)
,
M. Jylhä
(22)
,
T.B.L. Kirkwood
(14)
,
P. Kristensen
(23)
,
P. Laiho
(24)
,
A Leon.
(25)
,
A. Marchisio
(12)
,
R. Masciulli
(15)
,
A. Nebel
(18)
,
G. Passarino
(17)
,
G. Pelicci
(26)
,
L. Peltonen
(24)
,
M. Perola
(24)
,
M Poulain
(20)
,
I.M. Rea
(27)
,
J. Remacle
(28)
,
Jm Robine
(29)
,
S. Schreiber
(18)
,
M. Scurti
(2)
,
F. Sevini
(2)
,
E. Sikora
(10)
,
A. Skouteri
(21)
,
P.E. Slagboom
(5, 16)
,
L. Spazzafumo
(30)
,
M. A. Stazi
(15)
,
V. Toccaceli
(15)
,
O. Toussaint
(31)
,
O. Törnwall
(24)
,
J. W. Vaupel
(19)
,
K. Voutetakis
(21)
,
C. Franceschi
(2)
1
SDU -
University of Southern Denmark
2 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
3 2L2S - Laboratoire Lorrain de Sciences Sociales
4 INSERM - Institut National de la Santé et de la Recherche Médicale
5 Netherlands Consortium for Healthy Ageing
6 Institute of Gerontology [Kiev]
7 CEPH - Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris]
8 BGI - Beijing Genomics Institute [Shenzhen]
9 Institute of Human Genetics [Aarhus]
10 Nencki Institute of Experimental Biology
11 Medical University of Warsaw - Poland
12 UNISS - Università degli Studi di Sassari = University of Sassari [Sassari]
13 OUH - Odense University Hospital
14 Newcastle University [Newcastle]
15 ISS - Istituto Superiore di Sanità = National Institute of Health
16 LUMC - Leiden University Medical Center
17 Unical - Università della Calabria [Arcavacata di Rende]
18 Institute of Clinical Molecular Biology
19 MPIDR - Max Planck Institute for Demographic Research
20 UCL - Université Catholique de Louvain = Catholic University of Louvain
21 National Hellenic Research Foundation [Athens]
22 Tampere School of Public Health
23 Aarhus University [Aarhus]
24 The National Institute for Health and Welfare
25 Research Innovation [Italy]
26 IFOM Institute of Milan
27 QUB - Queen's University [Belfast]
28 Eppendorf Array Technologies
29 CERMES3 - UMR 8211 / U988 / UM 7 - CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
30 Istituto Nazionale Ricovero e Cura Anziani
31 UNamur - Université de Namur [Namur]
2 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
3 2L2S - Laboratoire Lorrain de Sciences Sociales
4 INSERM - Institut National de la Santé et de la Recherche Médicale
5 Netherlands Consortium for Healthy Ageing
6 Institute of Gerontology [Kiev]
7 CEPH - Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris]
8 BGI - Beijing Genomics Institute [Shenzhen]
9 Institute of Human Genetics [Aarhus]
10 Nencki Institute of Experimental Biology
11 Medical University of Warsaw - Poland
12 UNISS - Università degli Studi di Sassari = University of Sassari [Sassari]
13 OUH - Odense University Hospital
14 Newcastle University [Newcastle]
15 ISS - Istituto Superiore di Sanità = National Institute of Health
16 LUMC - Leiden University Medical Center
17 Unical - Università della Calabria [Arcavacata di Rende]
18 Institute of Clinical Molecular Biology
19 MPIDR - Max Planck Institute for Demographic Research
20 UCL - Université Catholique de Louvain = Catholic University of Louvain
21 National Hellenic Research Foundation [Athens]
22 Tampere School of Public Health
23 Aarhus University [Aarhus]
24 The National Institute for Health and Welfare
25 Research Innovation [Italy]
26 IFOM Institute of Milan
27 QUB - Queen's University [Belfast]
28 Eppendorf Array Technologies
29 CERMES3 - UMR 8211 / U988 / UM 7 - CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
30 Istituto Nazionale Ricovero e Cura Anziani
31 UNamur - Université de Namur [Namur]
Frédéric Balard
- Fonction : Auteur
- PersonId : 181977
- IdHAL : frederic-balard
- IdRef : 127284788
Matthias Beekmann
- Fonction : Auteur
- PersonId : 740641
- IdHAL : matthias-beekmann
- IdRef : 143041924
M Poulain
- Fonction : Auteur
- PersonId : 748884
- IdHAL : marius-poulain
Jm Robine
- Fonction : Auteur
- PersonId : 746403
- IdHAL : jm-robine
- ORCID : 0000-0002-4111-6195
- IdRef : 031816533
Résumé
In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information
about health, life style, and family composition.
From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identifiedand included in the project. In addition, 2548 younger control persons aged 50–75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies).
Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
|
Résumé |
en
In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information
about health, life style, and family composition.
From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identifiedand included in the project. In addition, 2548 younger control persons aged 50–75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies).
Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.
|
Auteur(s) |
A. Skytthe
1
, S. Valensin
2
, B. Jeune
1
, E. Cevenini
2
, Frédéric Balard
3, 4
, Matthias Beekmann
5
, V. Bezrukov
6
, H. Blanche
7
, L. Bolund
8, 9
, K. Broczek
10, 11
, C. Carru
12
, K. Christensen
1, 13
, L. Christiansen
1
, J. C. Collerton
14
, R. Cotichini
15
, A.J.M. de Craen
16
, S. Dato
17
, K. Davies
14
, C. de Benedictis
17
, L. Deiana
12
, F. Flachsbart
18
, J. Gampe
19
, C. Gilbault
20
, E.S. Gonos
21
, E. Haimes
14
, A. Hervonen
22
, M.A. Hurme
22
, D. Janiszewska
10
, M. Jylhä
22
, T.B.L. Kirkwood
14
, P. Kristensen
23
, P. Laiho
24
, A Leon.
25
, A. Marchisio
12
, R. Masciulli
15
, A. Nebel
18
, G. Passarino
17
, G. Pelicci
26
, L. Peltonen
24
, M. Perola
24
, M Poulain
20
, I.M. Rea
27
, J. Remacle
28
, Jm Robine
29
, S. Schreiber
18
, M. Scurti
2
, F. Sevini
2
, E. Sikora
10
, A. Skouteri
21
, P.E. Slagboom
5, 16
, L. Spazzafumo
30
, M. A. Stazi
15
, V. Toccaceli
15
, O. Toussaint
31
, O. Törnwall
24
, J. W. Vaupel
19
, K. Voutetakis
21
, C. Franceschi
2
1
SDU -
University of Southern Denmark
( 50786 )
- 5320 Odense
- Danemark
2
UNIBO -
Alma Mater Studiorum Università di Bologna = University of Bologna
( 30978 )
- Via Zamboni, 33 - 40126 Bologna
- Italie
3
2L2S -
Laboratoire Lorrain de Sciences Sociales
( 247144 )
- Université de Lorraine, CLSH, 23 Bd Albert 1er, BP 13397, 54015 Nancy Cedex
- France
4
INSERM -
Institut National de la Santé et de la Recherche Médicale
( 303623 )
- 101, rue de Tolbiac, 75013 Paris
- France
5
Netherlands Consortium for Healthy Ageing
( 180091 )
- PO Box 9600, 2300 RC Leiden
- Pays-Bas
6
Institute of Gerontology [Kiev]
( 1085761 )
- Ukraine
7
CEPH -
Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris]
( 505265 )
- 27 rue Juliette Dodu 75010 Paris
- France
8
BGI -
Beijing Genomics Institute [Shenzhen]
( 228027 )
- 11F, Bei Shan Industrial Zone Yantian District Shenzhen 518083
- Chine
9
Institute of Human Genetics [Aarhus]
( 1085762 )
- Danemark
10
Nencki Institute of Experimental Biology
( 67943 )
- WARSAW
- Pologne
11
Medical University of Warsaw - Poland
( 302595 )
- Pologne
12
UNISS -
Università degli Studi di Sassari = University of Sassari [Sassari]
( 568173 )
- via Vienna 2, 07100
Sassari,
- Italie
13
OUH -
Odense University Hospital
( 447266 )
- J. B. Winsløws Vej 4, 5000 Odense, Danemark
- Danemark
14
Newcastle University [Newcastle]
( 252912 )
- Newcastle upon Tyne NE1 7RU
- Royaume-Uni
15
ISS -
Istituto Superiore di Sanità = National Institute of Health
( 359183 )
- 299, Viale Regina Elena, 00161 – Roma
- Italie
16
LUMC -
Leiden University Medical Center
( 300851 )
- Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden
- Pays-Bas
17
Unical -
Università della Calabria [Arcavacata di Rende]
( 103704 )
- Campus di Arcavacata via Pietro Bucci 87036 Arcavacata di Rende (CS)
- Italie
18
Institute of Clinical Molecular Biology
( 168434 )
- Kiel 24105
- Allemagne
19
MPIDR -
Max Planck Institute for Demographic Research
( 114184 )
- Konrad-Zuse-Straße 1, 18057 Rostock
- Allemagne
20
UCL -
Université Catholique de Louvain = Catholic University of Louvain
( 92863 )
- Place de l'Université 1 - 1348 Louvain-La-Neuve
- Belgique
21
National Hellenic Research Foundation [Athens]
( 469482 )
- Grèce
22
Tampere School of Public Health
( 119752 )
- 33014;Tampere
- Finlande
23
Aarhus University [Aarhus]
( 19908 )
- Nordre Ringgade 1 DK-8000 Aarhus C
- Danemark
24
The National Institute for Health and Welfare
( 147811 )
- Kuopio
- Finlande
25
Research Innovation [Italy]
( 1085764 )
- Italie
26
IFOM Institute of Milan
( 1085765 )
- Milan
- Italie
27
QUB -
Queen's University [Belfast]
( 232128 )
- University Road, Belfast, BT7 1NN, Northern Ireland, UK
- Irlande
28
Eppendorf Array Technologies
( 34537 )
- 5000 Namur
- Belgique
29
CERMES3 - UMR 8211 / U988 / UM 7 -
CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
( 176631 )
- 7 rue Guy Môquet - BP 8 - 94801 Villejuif Cedex
Site administratif : Campus CNRS- 7, rue Guy Môquet- BP 8- 94801 Villejuif Cedex
Site Paris: CUSP (Centre universitaire des Saints-Pères)- Bâtiment Jacob (3ème étage)- 45, rue des Saints-Pères- 75270 Paris Cedex 06
- France
30
Istituto Nazionale Ricovero e Cura Anziani
( 1085766 )
- Italie
31
UNamur -
Université de Namur [Namur]
( 364917 )
- Rempart de la Vierge 8, 5000 Namur
- Belgique
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2011
|
Volume |
46
|
Numéro |
11
|
Page/Identifiant |
934-945
|
Date de publication électronique |
2011-08-16
|
Domaine(s) |
|
Projet(s) Européen(s) |
|
Mots-clés |
en
Longevity, Healthy ageing, Nonagenarian sib pairs, Genetics, Europe
|
DOI | 10.1016/j.exger.2011.08.005 |
Origine :
Fichiers produits par l'(les) auteur(s)
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