Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples
Jér̂ome René Lechien
(1, 2)
,
Francois Bobin
(2, 3)
,
Vinciane Muls
(2)
,
Mihaela Horoi
,
Marie Paule Thill
,
Didier Dequanter
(2)
,
Camille L. Finck
(2)
,
Alexandra Rodriguez
(2)
,
Sven Saussez
(2)
Jér̂ome René Lechien
- Fonction : Auteur correspondant
Mihaela Horoi
- Fonction : Auteur
Marie Paule Thill
- Fonction : Auteur
Résumé
Objectives/Hypothesis: To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR). Study Design: Non-controlled Prospective Study. Methods: Patients with positive LPR regarding hypopharyngeal–esophageal impedance-pH monitoring (HEMII-pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods and beverages consumed during meals and before the pepsin samples. The 3-month treatment was based on the association of diet, proton pump inhibitors, alginate, or magaldrate regarding the HEMII-pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used for assessing the pre- to posttreatment clinical evolution. The Refluxogenic Diet Score and the Refluxogenic Score of a Dish (RESDI) were used to assess the refluxogenic potential of foods and beverages. The relationship between saliva pepsin concentration, HEMII-pH, RESDI, RSS, and RSA was investigated through multiple linear regression. Results: Forty-two patients were included. The saliva pepsin concentration of the 24-hour period of testing was significantly associated with foods and beverages consumed during the testing period and the evening dinner (rs = 0.973, P <.001). RSS and RSA significantly improved throughout treatment. The level of saliva pepsin in the morning was a negative predictive factor of the therapeutic response regarding RSA and RSS (P <.036). Conclusions: Foods and beverages may significantly impact the saliva pepsin concentration of patients with LPR. Patients with high-level saliva pepsin in the morning had lower therapeutic response compared with those with low-level saliva pepsin. Level of Evidence: 4 Laryngoscope, 131:350–359, 2021.
Domaines
LinguistiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples
|
Résumé |
en
Objectives/Hypothesis: To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR). Study Design: Non-controlled Prospective Study. Methods: Patients with positive LPR regarding hypopharyngeal–esophageal impedance-pH monitoring (HEMII-pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods and beverages consumed during meals and before the pepsin samples. The 3-month treatment was based on the association of diet, proton pump inhibitors, alginate, or magaldrate regarding the HEMII-pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used for assessing the pre- to posttreatment clinical evolution. The Refluxogenic Diet Score and the Refluxogenic Score of a Dish (RESDI) were used to assess the refluxogenic potential of foods and beverages. The relationship between saliva pepsin concentration, HEMII-pH, RESDI, RSS, and RSA was investigated through multiple linear regression. Results: Forty-two patients were included. The saliva pepsin concentration of the 24-hour period of testing was significantly associated with foods and beverages consumed during the testing period and the evening dinner (rs = 0.973, P <.001). RSS and RSA significantly improved throughout treatment. The level of saliva pepsin in the morning was a negative predictive factor of the therapeutic response regarding RSA and RSS (P <.036). Conclusions: Foods and beverages may significantly impact the saliva pepsin concentration of patients with LPR. Patients with high-level saliva pepsin in the morning had lower therapeutic response compared with those with low-level saliva pepsin. Level of Evidence: 4 Laryngoscope, 131:350–359, 2021.
|
Auteur(s) |
Jér̂ome René Lechien
1, 2
, Francois Bobin
2, 3
, Vinciane Muls
2
, Mihaela Horoi
, Marie Paule Thill
, Didier Dequanter
2
, Camille L. Finck
2
, Alexandra Rodriguez
2
, Sven Saussez
2
1
UVSQ Santé -
Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil
( 472222 )
- 2 avenue de la Source de la Bièvre - 78180 Montigny-le-Bretonneux
- France
2
SFORL -
SFORL
( 242062 )
- SFORL, 26, rue Lalo, 75116 Paris
- France
3
ELSAN-Polyclinique de Poitiers
( 575016 )
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2021
|
Volume |
131
|
Numéro |
2
|
Page/Identifiant |
350-359
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
beverages, diet, foods, laryngitis, laryngopharyngeal, pepsin, Reflux, saliva
|
DOI | 10.1002/lary.28756 |
Pubmed Id | 32510588 |
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