ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
H Brodaty
(1)
,
C Woolf
(1)
,
S Andersen
(2)
,
N Barzilai
(3)
,
C Brayne
(4)
,
Ks Cheung
(5)
,
Mm Corrada
(6)
,
Jd Crawford
(1)
,
C Daly
(1)
,
Y Gondo
(7)
,
B Hagberg
(8)
,
N Hirose
(9)
,
H Holstege
(10)
,
C Kawas
(6)
,
J Kaye
(11)
,
Na Kochan
(1)
,
Bh Lau
(5)
,
U Lucca
(12)
,
G Marcon
(13)
,
P Martin
(14)
,
Lw Poon
(15)
,
R Richmond
(16)
,
Jean-Marie Robine
(17)
,
I Skoog
(18)
,
Mj Slavin
(1)
,
J Szewieczek
(19)
,
M Tettamanti
(12)
,
J Viña
(20)
,
T Perls
(2)
,
Ps Sachdev
(1)
1
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
2 BUSM - Boston University School of Medicine
3 Albert Einstein College of Medicine [New York]
4 CAM - University of Cambridge [UK]
5 CUHK - The Chinese University of Hong Kong [Hong Kong]
6 UC Irvine - University of California [Irvine]
7 Osaka University [Osaka]
8 Skane University Hospital [Lund]
9 Keio University School of Medicine [Tokyo, Japan]
10 VU University Medical Center [Amsterdam]
11 OHSU - Oregon Health and Science University [Portland]
12 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
13 Università degli Studi di Udine - University of Udine [Italie]
14 ISU - Iowa State University
15 University of Georgia [USA]
16 UNSW Faculty of Medicine [Sydney]
17 CERMES3 - UMR 8211 / U988 / UM 7 - CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
18 Sahlgrenska University Hospital [Gothenburg]
19 SUM - Medical University of Silesia
20 UV - Universitat de València
2 BUSM - Boston University School of Medicine
3 Albert Einstein College of Medicine [New York]
4 CAM - University of Cambridge [UK]
5 CUHK - The Chinese University of Hong Kong [Hong Kong]
6 UC Irvine - University of California [Irvine]
7 Osaka University [Osaka]
8 Skane University Hospital [Lund]
9 Keio University School of Medicine [Tokyo, Japan]
10 VU University Medical Center [Amsterdam]
11 OHSU - Oregon Health and Science University [Portland]
12 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri"
13 Università degli Studi di Udine - University of Udine [Italie]
14 ISU - Iowa State University
15 University of Georgia [USA]
16 UNSW Faculty of Medicine [Sydney]
17 CERMES3 - UMR 8211 / U988 / UM 7 - CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
18 Sahlgrenska University Hospital [Gothenburg]
19 SUM - Medical University of Silesia
20 UV - Universitat de València
Jean-Marie Robine
- Fonction : Auteur
- PersonId : 746403
- IdHAL : jm-robine
- ORCID : 0000-0002-4111-6195
- IdRef : 031816533
Résumé
Background : Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary Aim : is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. METHODS: Studies focusing on individuals aged >/=95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. DISCUSSION: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
Domaines
Sciences de l'Homme et SociétéFormat du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
|
Résumé |
en
Background : Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary Aim : is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups. METHODS: Studies focusing on individuals aged >/=95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress. DISCUSSION: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments.
|
Auteur(s) |
H Brodaty
1
, C Woolf
1
, S Andersen
2
, N Barzilai
3
, C Brayne
4
, Ks Cheung
5
, Mm Corrada
6
, Jd Crawford
1
, C Daly
1
, Y Gondo
7
, B Hagberg
8
, N Hirose
9
, H Holstege
10
, C Kawas
6
, J Kaye
11
, Na Kochan
1
, Bh Lau
5
, U Lucca
12
, G Marcon
13
, P Martin
14
, Lw Poon
15
, R Richmond
16
, Jean-Marie Robine
17
, I Skoog
18
, Mj Slavin
1
, J Szewieczek
19
, M Tettamanti
12
, J Viña
20
, T Perls
2
, Ps Sachdev
1
1
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
( 1056057 )
- Australie
2
BUSM -
Boston University School of Medicine
( 43432 )
- Boston, Massachusetts 02118
- États-Unis
3
Albert Einstein College of Medicine [New York]
( 418975 )
- 300 Morris Park Avenue Bronx, NY 10461
- États-Unis
4
CAM -
University of Cambridge [UK]
( 237843 )
- The Old Schools, Trinity Lane, Cambridge CB2 1TN
- Royaume-Uni
5
CUHK -
The Chinese University of Hong Kong [Hong Kong]
( 93116 )
- Shatin, NT, Hong Kong SAR
- Chine
6
UC Irvine -
University of California [Irvine]
( 445806 )
- Irvine, CA 92697
- États-Unis
7
Osaka University [Osaka]
( 206804 )
- 1-1 Yamadaoka, Suita,Osaka 565-0871
- Japon
8
Skane University Hospital [Lund]
( 344927 )
- Getingevägen 4, 222 41 Lund
- Suède
9
Keio University School of Medicine [Tokyo, Japan]
( 479077 )
- 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582.
- Japon
10
VU University Medical Center [Amsterdam]
( 410432 )
- De Boelelaan 1118, 1081 HZ Amsterdam
- Pays-Bas
11
OHSU -
Oregon Health and Science University [Portland]
( 311931 )
- 3181 S.W. Sam Jackson Park Rd.
Portland, Oregon 97239-3098
- États-Unis
12
IRCCS -
Istituto di Ricerche Farmacologiche "Mario Negri"
( 355521 )
- Via Mario Negri, 2, 20156 Milano
- Italie
13
Università degli Studi di Udine - University of Udine [Italie]
( 358631 )
- via Palladio 8, 33100 Udine
- Italie
14
ISU -
Iowa State University
( 302747 )
- Ames, Iowa 50011
- États-Unis
15
University of Georgia [USA]
( 303339 )
- Athens, GA 30602
- États-Unis
16
UNSW Faculty of Medicine [Sydney]
( 525432 )
- Wallace Wurth Building - UNSW Sydney, 18 High St, Kensington NSW 2052
- Australie
17
CERMES3 - UMR 8211 / U988 / UM 7 -
CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société
( 176631 )
- 7 rue Guy Môquet - BP 8 - 94801 Villejuif Cedex
Site administratif : Campus CNRS- 7, rue Guy Môquet- BP 8- 94801 Villejuif Cedex
Site Paris: CUSP (Centre universitaire des Saints-Pères)- Bâtiment Jacob (3ème étage)- 45, rue des Saints-Pères- 75270 Paris Cedex 06
- France
18
Sahlgrenska University Hospital [Gothenburg]
( 59650 )
- Blå Stråket 5, 413 45 Gothenburg
- Suède
19
SUM -
Medical University of Silesia
( 334351 )
- Katowice
- Pologne
20
UV -
Universitat de València
( 303680 )
- Av. de Blasco Ibáñez, 13, 46010 València
- Espagne
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2016
|
Volume |
16
|
Page/Identifiant |
52
|
Domaine(s) |
|
Mots-clés |
en
Centenarians, Dementia, Incidence, International, Prevalence, Risk factors
|
DOI | 10.1186/s12883-016-0569-4 |
Pubmed Id | 27098177 |
PubMed Central | PMC4839126 |
Origine :
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