Peer presence and familiarity as key factors to reduce cocaine intake: An effect mediated by the Subthalamic Nucleus
Elodie Giorla
(1)
,
Sandra Nordmann
(2, 3)
,
Cassandre Vielle
(1)
,
Yann Pelloux
(1)
,
Perrine Roux
(2, 3)
,
Camélia Protopopescu
(2, 3)
,
Christine Manrique
(4)
,
Karen Davranche
(5)
,
Christian Montanari
(1)
,
Lisa Giorgi
(1)
,
Antoine Vilotitch
(2, 3)
,
Pascal Huguet
(6)
,
Patrizia Carrieri
(2, 3)
,
Christelle Baunez
(1)
1
INT -
Institut de Neurosciences de la Timone
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 ORS PACA - Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille]
4 INP - Institut de neurophysiopathologie
5 LPC - Laboratoire de psychologie cognitive
6 LAPSCO - Laboratoire de Psychologie Sociale et Cognitive
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 ORS PACA - Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille]
4 INP - Institut de neurophysiopathologie
5 LPC - Laboratoire de psychologie cognitive
6 LAPSCO - Laboratoire de Psychologie Sociale et Cognitive
Yann Pelloux
- Fonction : Auteur
- PersonId : 781509
- ORCID : 0000-0001-8262-9969
- IdRef : 08297831X
Pascal Huguet
- Fonction : Auteur
- PersonId : 182791
- IdHAL : pascal-huguet
- ORCID : 0000-0002-0707-7655
- IdRef : 034318577
Patrizia Carrieri
- Fonction : Auteur
- PersonId : 21176
- IdHAL : patrizia-carrieri
- ORCID : 0000-0002-6794-4837
- IdRef : 144323036
Christelle Baunez
- Fonction : Auteur
- PersonId : 178360
- IdHAL : christelle-baunez
- ORCID : 0000-0002-4368-652X
- IdRef : 083548912
Résumé
Rationale
Stimulant use, including cocaine, often occurs in a social context whose influence is important to understand to decrease intake and reduce associated harms. Although the importance of social influence in the context of drug addiction is known, there is a need for studies assessing its neurobiological substrate and for translational research.
Objectives
Here, we explored the influence of peer presence and familiarity on cocaine intake and its neurobiological basis. Given the regulatory role of the subthalamic nucleus (STN) on cocaine intake and emotions, we investigated its role on such influence of social context on cocaine intake.
Methods
We first compared cocaine consumption in various conditions (with no peer present or with peers with different characteristics: abstinent peer or drug-taking peer, familiar or not, cocaine-naive or not, dominant or subordinate) in rats (n = 90). Then, with a translational approach, we assessed the influence of the social context (alone, in the group, in a dyad with familiar or non-familiar peers) on drug intake in human drug users (n = 77).
Results
The drug consumption was reduced when a peer was present, abstinent, or drug-taking as well, and further diminished when the peer was non-familiar. The presence of a non-familiar and drug-naive peer represents key conditions to diminish cocaine intake. The STN lesion by itself reduced cocaine intake to the level reached in presence of a non-familiar naive peer and affected social cognition, positioning the STN as one neurobiological substrate of social influence on drug intake. Then, the human study confirmed the beneficial effect of social presence, especially of non-familiar peers.
Conclusion
Our results indirectly support the use of social interventions and harm reduction strategies and position the STN as a key cerebral structure to mediate these effects.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Peer presence and familiarity as key factors to reduce cocaine intake: An effect mediated by the Subthalamic Nucleus
|
Résumé |
en
Rationale
Stimulant use, including cocaine, often occurs in a social context whose influence is important to understand to decrease intake and reduce associated harms. Although the importance of social influence in the context of drug addiction is known, there is a need for studies assessing its neurobiological substrate and for translational research.
Objectives
Here, we explored the influence of peer presence and familiarity on cocaine intake and its neurobiological basis. Given the regulatory role of the subthalamic nucleus (STN) on cocaine intake and emotions, we investigated its role on such influence of social context on cocaine intake.
Methods
We first compared cocaine consumption in various conditions (with no peer present or with peers with different characteristics: abstinent peer or drug-taking peer, familiar or not, cocaine-naive or not, dominant or subordinate) in rats (n = 90). Then, with a translational approach, we assessed the influence of the social context (alone, in the group, in a dyad with familiar or non-familiar peers) on drug intake in human drug users (n = 77).
Results
The drug consumption was reduced when a peer was present, abstinent, or drug-taking as well, and further diminished when the peer was non-familiar. The presence of a non-familiar and drug-naive peer represents key conditions to diminish cocaine intake. The STN lesion by itself reduced cocaine intake to the level reached in presence of a non-familiar naive peer and affected social cognition, positioning the STN as one neurobiological substrate of social influence on drug intake. Then, the human study confirmed the beneficial effect of social presence, especially of non-familiar peers.
Conclusion
Our results indirectly support the use of social interventions and harm reduction strategies and position the STN as a key cerebral structure to mediate these effects.
|
Auteur(s) |
Elodie Giorla
1
, Sandra Nordmann
2, 3
, Cassandre Vielle
1
, Yann Pelloux
1
, Perrine Roux
2, 3
, Camélia Protopopescu
2, 3
, Christine Manrique
4
, Karen Davranche
5
, Christian Montanari
1
, Lisa Giorgi
1
, Antoine Vilotitch
2, 3
, Pascal Huguet
6
, Patrizia Carrieri
2, 3
, Christelle Baunez
1
1
INT -
Institut de Neurosciences de la Timone
( 202046 )
- Faculté de Médecine - Bâtiment Neurosciences 27, Bd Jean Moulin - 13385 Marseille Cedex 05
- France
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
3
ORS PACA -
Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille]
( 521833 )
- France
4
INP -
Institut de neurophysiopathologie
( 527029 )
- Faculté de Médecine Campus Timone
27 Boulevard Jean MOULIN
13385 Marseille - France
- France
5
LPC -
Laboratoire de psychologie cognitive
( 849 )
- Pôle 3 C, Case D 3 place Victor Hugo 13331 Marseille Cedex 3
- France
6
LAPSCO -
Laboratoire de Psychologie Sociale et Cognitive
( 1063675 )
- UFR Psychologie - Bâtiment Paul Collomb, 34 Avenue Carnot, 63001 Clermont-Ferrand
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2022-04
|
Volume |
239
|
Numéro |
4
|
Page/Identifiant |
1097-1113
|
Domaine(s) |
|
BioRxiv | 2021.06.08.447497 |
DOI | 10.1007/s00213-021-06033-0 |
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