The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study
Bénédicte Stengel
(1)
,
Christian Combe
(2, 3)
,
Christian Jacquelinet
,
Serge Briançon
(4, 5)
,
Denis Fouque
(6)
,
Luc Frimat
(7)
,
Christophe Pascal
(8)
,
Yves-Edouard Herpe
(9)
,
Jean-François Deleuze
(10)
,
Joost P. Schanstra
(11)
,
Ron L. Pisoni
,
Bruce M Robinson
,
Ziad A Massy
(12, 13)
1
CESP -
Centre de recherche en épidémiologie et santé des populations
2 Fibrose hépatique et cancer du foie
3 Service de Néphrologie-transplantation-dialyse [Bordeaux]
4 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
5 Pôle S2R - Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy]
6 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
7 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
8 GRAPHOS - IFROSS Recherche
9 Transfert de gènes dans le foie : applications thérapeutiques
10 Sanofi-Aventis
11 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
12 Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques
13 Services de Pharmacologie Clinique et Néphrologie
2 Fibrose hépatique et cancer du foie
3 Service de Néphrologie-transplantation-dialyse [Bordeaux]
4 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
5 Pôle S2R - Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy]
6 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
7 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
8 GRAPHOS - IFROSS Recherche
9 Transfert de gènes dans le foie : applications thérapeutiques
10 Sanofi-Aventis
11 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
12 Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques
13 Services de Pharmacologie Clinique et Néphrologie
Christian Combe
- Fonction : Auteur
- PersonId : 756127
- ORCID : 0000-0002-0360-573X
- IdRef : 058708871
Christian Jacquelinet
- Fonction : Auteur
Denis Fouque
- Fonction : Auteur
- PersonId : 761251
- ORCID : 0000-0002-9707-7199
- IdRef : 068884958
Luc Frimat
- Fonction : Auteur
- PersonId : 759372
- IdRef : 113414099
Christophe Pascal
- Fonction : Auteur
- PersonId : 20106
- IdHAL : christophe-pascal
- ORCID : 0000-0002-4667-644X
- IdRef : 083503439
Joost P. Schanstra
- Fonction : Auteur
- PersonId : 837350
- ORCID : 0000-0002-7471-372X
- IdRef : 076749304
Ron L. Pisoni
- Fonction : Auteur
Bruce M Robinson
- Fonction : Auteur
Ziad A Massy
- Fonction : Auteur
- PersonId : 1003368
- ORCID : 0000-0001-5771-5996
Résumé
Background While much has been learned about the epidemiology and treatment of end-stage renal disease (ESRD) in the last 30 years, chronic kidney disease (CKD) before the end-stage has been less investigated. Not enough is known about factors associated with CKD progression and complications, as well as its transition to ESRD. We designed the CKD-renal epidemiology and information network (REIN) cohort to provide a research platform to address these key questions and to assess clinical practices and costs in patients with moderate or advanced CKD. Methods A total of 46 clinic sites and 4 renal care networks participate in the cohort. A stratified selection of clinic sites yields a sample that represents a diversity of settings, e.g. geographic region, and public versus for-profit and non-for-profit private clinics. In each site, 60-90 patients with CKD are enrolled at a routine clinic visit during a 12-month enrolment phase: 3600 total, including 1800 with Stage 3 and 1800 with Stage 4 CKD. Follow-up will continue for 5 years, including after initiation of renal replacement therapy. Data will be collected from medical records at inclusion and at yearly intervals, as well as from self-administered patient questionnaires and provider-level questionnaires. Patients will also be interviewed at baseline, and at 1, 3 and 5 years. Healthcare costs will also be determined. Blood and urine samples will be collected and stored for future studies on all patients at enrolment and at study end, and at 1 and 3 years in a subsample of 1200. Conclusions The CKD-REIN cohort will serve to improve our understanding of the biological, clinical and healthcare system determinants associated with CKD progression and adverse outcomes as well as of international variations in collaboration with the CKD Outcome and Practice Pattern Study (CKDopps). It will foster CKD epidemiology and outcomes research and provide evidence to improve the health and quality of life of patients with CKD and the performances of the healthcare system in this field.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study
|
Résumé |
en
Background While much has been learned about the epidemiology and treatment of end-stage renal disease (ESRD) in the last 30 years, chronic kidney disease (CKD) before the end-stage has been less investigated. Not enough is known about factors associated with CKD progression and complications, as well as its transition to ESRD. We designed the CKD-renal epidemiology and information network (REIN) cohort to provide a research platform to address these key questions and to assess clinical practices and costs in patients with moderate or advanced CKD. Methods A total of 46 clinic sites and 4 renal care networks participate in the cohort. A stratified selection of clinic sites yields a sample that represents a diversity of settings, e.g. geographic region, and public versus for-profit and non-for-profit private clinics. In each site, 60-90 patients with CKD are enrolled at a routine clinic visit during a 12-month enrolment phase: 3600 total, including 1800 with Stage 3 and 1800 with Stage 4 CKD. Follow-up will continue for 5 years, including after initiation of renal replacement therapy. Data will be collected from medical records at inclusion and at yearly intervals, as well as from self-administered patient questionnaires and provider-level questionnaires. Patients will also be interviewed at baseline, and at 1, 3 and 5 years. Healthcare costs will also be determined. Blood and urine samples will be collected and stored for future studies on all patients at enrolment and at study end, and at 1 and 3 years in a subsample of 1200. Conclusions The CKD-REIN cohort will serve to improve our understanding of the biological, clinical and healthcare system determinants associated with CKD progression and adverse outcomes as well as of international variations in collaboration with the CKD Outcome and Practice Pattern Study (CKDopps). It will foster CKD epidemiology and outcomes research and provide evidence to improve the health and quality of life of patients with CKD and the performances of the healthcare system in this field.
|
Auteur(s) |
Bénédicte Stengel
1
, Christian Combe
2, 3
, Christian Jacquelinet
, Serge Briançon
4, 5
, Denis Fouque
6
, Luc Frimat
7
, Christophe Pascal
8
, Yves-Edouard Herpe
9
, Jean-François Deleuze
10
, Joost P. Schanstra
11
, Ron L. Pisoni
, Bruce M Robinson
, Ziad A Massy
12, 13
1
CESP -
Centre de recherche en épidémiologie et santé des populations
( 106188 )
- 16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
- France
2
Fibrose hépatique et cancer du foie
( 27761 )
- 146 rue léo saignat, 33076 Bordeaux Cedex
- France
3
Service de Néphrologie-transplantation-dialyse [Bordeaux]
( 410000 )
- pl Amélie Raba Léon
33076 BORDEAUX CEDEX
- France
4
APEMAC -
Maladies chroniques, santé perçue, et processus d'adaptation
( 209763 )
- Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54505 Vandoeuvre Les Nancy
- France
5
Pôle S2R -
Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy]
( 487469 )
- 5 Rue du Morvan, 54500 Vandœuvre-lès-Nancy
- France
6
CarMeN -
Cardiovasculaire, métabolisme, diabétologie et nutrition
( 139835 )
- Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex INSA, Bât. IMBL, La Doua - 11 Avenue Jean Capelle - 69621 Villeurbanne Cedex
- France
7
METRICS -
Evaluation des technologies de santé et des pratiques médicales - ULR 2694
( 221576 )
- 1, place de Verdun 59045 - Lille cedex
- France
8
GRAPHOS - IFROSS Recherche
( 156830 )
- Université Jean Moulin - Lyon3 18 rue Chevreul 69007 Lyon
- France
9
Transfert de gènes dans le foie : applications thérapeutiques
( 2649 )
- CHU Bicêtre, batiment Grégory Pincus 80, Rue du General Leclerc 94276 LE KREMLIN BICETRE CEDEX
- France
10
Sanofi-Aventis
( 15375 )
- Evry Genetics Centre 2 rue Gaston Crémieux CP5705 91057 Evry
- France
11
I2MC -
Institut des Maladies Métaboliques et Cardiovasculaires
( 139749 )
- 1 avenue du Prof Jean Poulhes - BP 84225 - 31432 Toulouse Cedex 4
- France
12
Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques
( 2706 )
- CHU Amiens Sud Avenue Rene Laennec 80054 Amiens
- France
13
Services de Pharmacologie Clinique et Néphrologie
( 237193 )
- Amiens
- France
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Audience |
Internationale
|
Date de publication |
2013-09-24
|
Date de publication électronique |
2013-09-24
|
Page/Identifiant |
1-9
|
Domaine(s) |
|
Projet(s) ANR |
|
Mots-clés |
en
biomarkers, chronic kidney disease, clinical practice, cohort, quality of life
|
DOI | 10.1093/ndt/gft388 |
PubMed Central | PMC4106639 |
Loading...