Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers
André Sagna
(1, 2, 3)
,
Daouda Kassié
(4, 5)
,
Agnès Couvray
(6)
,
Akré Maurice Adja
(2)
,
Emmanuel Hermann
(7)
,
Gilles Riveau
(7, 3)
,
Gérard Salem
(6, 8)
,
Florence Fournet
(9, 3)
,
Franck Remoue
(10)
1
MIVEGEC -
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 IPR - Institut Pierre Richet
3 Centre de Recherche Biomédicale - Espoir pour la santé (EPLS)
4 UMR ASTRE - Animal, Santé, Territoires, Risques et Ecosystèmes
5 Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz
6 CEPED - UMR_D 196 - Centre population et développement
7 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
8 LADYSS - Laboratoire Dynamiques Sociales et Recomposition des Espaces
9 MIVEGEC-DEEVA - Diversity, ecology, evolution & Adaptation of arthropod vectors
10 MIVEGEC-VCG - Vector Control Group
2 IPR - Institut Pierre Richet
3 Centre de Recherche Biomédicale - Espoir pour la santé (EPLS)
4 UMR ASTRE - Animal, Santé, Territoires, Risques et Ecosystèmes
5 Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz
6 CEPED - UMR_D 196 - Centre population et développement
7 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
8 LADYSS - Laboratoire Dynamiques Sociales et Recomposition des Espaces
9 MIVEGEC-DEEVA - Diversity, ecology, evolution & Adaptation of arthropod vectors
10 MIVEGEC-VCG - Vector Control Group
André Sagna
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1060357
- IdHAL : andre-sagna
- ORCID : 0000-0001-8586-792X
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Emmanuel Hermann
- Fonction : Auteur
- PersonId : 919784
Gilles Riveau
- Fonction : Auteur
- PersonId : 916898
Florence Fournet
- Fonction : Auteur
- PersonId : 173796
- IdHAL : florence-fournet
- ORCID : 0000-0003-0220-8131
- IdRef : 131032798
Franck Remoue
- Fonction : Auteur
- PersonId : 173723
- IdHAL : franck-remoue
- ORCID : 0000-0003-3220-5660
- IdRef : 05984552X
Résumé
BACKGROUND: Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites.METHODS: A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6-59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm-34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure.RESULTS: IgG response levels to gSG6-P1 and Nterm-34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods.CONCLUSIONS: Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers
|
Résumé |
en
BACKGROUND: Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites.METHODS: A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6-59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm-34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure.RESULTS: IgG response levels to gSG6-P1 and Nterm-34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods.CONCLUSIONS: Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs
|
Auteur(s) |
André Sagna
1, 2, 3
, Daouda Kassié
4, 5
, Agnès Couvray
6
, Akré Maurice Adja
2
, Emmanuel Hermann
7
, Gilles Riveau
7, 3
, Gérard Salem
6, 8
, Florence Fournet
9, 3
, Franck Remoue
10
1
MIVEGEC -
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
( 166573 )
- 911 Avenue Agropolis BP 64501 34394 Montpellier cedex 5
- France
2
IPR -
Institut Pierre Richet
( 340555 )
- Bouaké, Côte d'Ivoire
- Côte d’Ivoire
3
Centre de Recherche Biomédicale -
Espoir pour la santé (EPLS)
( 454872 )
- EPLS Sénégal
Maison des Programmes
263, route de la corniche. BP 226 Saint-Louis, Sénégal
tel: (221) 33 961 03 77
fax: (221) 33 961 03 77
- Sénégal
4
UMR ASTRE -
Animal, Santé, Territoires, Risques et Ecosystèmes
( 498087 )
- TA A-117 / E - Campus international de Baillarguet 34398 Montpellier Cedex 5, France
- France
5
Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz
( 350516 )
- Bobo-Dioulasso
- Burkina Faso
6
CEPED - UMR_D 196 -
Centre population et développement
( 86890 )
- 45 rue des Saints-Pères
75006 Paris
- France
7
CIIL -
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
( 106189 )
- 1 Rue du Professeur Calmette - Lille Cedex - 59019 - BP 245
- France
8
LADYSS -
Laboratoire Dynamiques Sociales et Recomposition des Espaces
( 1004856 )
- Université Paris Ouest Nanterre La Défense Bâtiment T 200 avenue de la République 92001 Nanterre cedex
- France
9
MIVEGEC-DEEVA -
Diversity, ecology, evolution & Adaptation of arthropod vectors
( 1052755 )
- France
10
MIVEGEC-VCG -
Vector Control Group
( 1052715 )
- France
|
Nom de la revue |
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Audience |
Internationale
|
Date de publication |
2019
|
Page/Identifiant |
1199-1208
|
Numéro |
7
|
Volume |
220
|
Comité de lecture |
Oui
|
Public visé |
Scientifique
|
Collaboration/Projet |
|
Financement |
|
Projet(s) ANR |
|
Domaine(s) |
|
Mots-clés |
en
Aedes, Anopheles, MBD risk, Nterm–34-kD, Urban area, gSG6-P1, salivary biomarkers
|
DOI | 10.1093/infdis/jiz289 |
ProdINRA | 487191 |
Pubmed Id | 31152664 |
UT key WOS | 000490986500017 |
Fichier principal
Sagna et al 2019_Spatial assessment of Human-mosquitoes contact using Ab-based biomarkers.pdf ( 778.96 Ko
)
Télécharger
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