The purpose of this article is to provide a gendered interpretation of transnational commerce migration, drawing on an empirical study of Tunisian women who practice frequent buying journeys in Naples, Italy. Analysing transnational trade from a gender perspective enables to consider women's lives not only in light of their multiple social positions, but also in light of the multiple spaces they connect each other through their migratory movements. Tunisian traders' mobility practices and their specific ‘know-how to circulate' display their gender belonging and positioning. At the same time, these practices are source of empowerment for women, as they lead to a reformulation of women and men roles within both the productive and the reproductive spheres. In fact, transnational trade allows women to pursue strategies of social upward mobility and autonomisation. Nevertheless, it has to be noted that these strategies can be performed only through numerous and continuous negotiations, both at the household level and at that of typically men spaces such as the travel routes and the buying places.