Analysis of hepatitis C virus strains circulating in republic of the Congo
Jean-François Cantaloube
(1)
,
Pierre Gallian
(1, 2)
,
Amelia Bokilo
(3)
,
François Jordier
(1)
,
Philippe Biagini
(1)
,
Houssam Attoui
(4)
,
Jacques Chiaroni
(1)
,
Philippe de Micco
(1)
Jean-François Cantaloube
- Fonction : Auteur
- PersonId : 764730
- ORCID : 0000-0001-6275-1668
- IdRef : 18162706X
Pierre Gallian
- Fonction : Auteur
- PersonId : 764731
- ORCID : 0000-0002-3310-5808
- IdRef : 067264506
Philippe Biagini
- Fonction : Auteur
- PersonId : 1182824
- IdHAL : philippe-biagini
- IdRef : 169831094
Houssam Attoui
- Fonction : Auteur
- PersonId : 744316
- IdHAL : houssam-attoui
- ORCID : 0000-0001-9639-9981
- IdRef : 169121119
Jacques Chiaroni
- Fonction : Auteur
- PersonId : 748906
- IdHAL : jacques-chiaroni
- ORCID : 0000-0002-3133-8990
Résumé
The aim of this study was to assess the seroprevalence, viremia, genotype distribution, and demographic history of hepatitis C virus (HCV) in the Republic of the Congo. Testing was carried out on sera samples collected in 2005 from 807 Bantus belonging to the Kongo, Teke, and Ngala subgroups and 80 Pygmies. Positive HCV serology was found in 50 (5.6%) individuals including31 (60%) who were viremic. Seroprevalence increased with age with a cutoff at 50 years:2.8% <50 versus 12% >50. Twenty-one strains belonged to four described subtypes, that is, 4c in eight cases, 4h in two, 4k in three, and 4r in eight. Ten strains could not be assigned to any known subtype and may represent six new variants, that is, subtype 4 in five cases and subtype 2 in one. Evolutionary analysis of subtype 4c and 4r sequences indicated a period of enhanced transmission in the mid-twentieth century probably due to iatrogenic causes. This study underlines the high genetic diversity of strains in the Republic of the Congo with nine subtypes 4 and one subtype 2.
Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Analysis of hepatitis C virus strains circulating in republic of the Congo
|
Résumé |
en
The aim of this study was to assess the seroprevalence, viremia, genotype distribution, and demographic history of hepatitis C virus (HCV) in the Republic of the Congo. Testing was carried out on sera samples collected in 2005 from 807 Bantus belonging to the Kongo, Teke, and Ngala subgroups and 80 Pygmies. Positive HCV serology was found in 50 (5.6%) individuals including31 (60%) who were viremic. Seroprevalence increased with age with a cutoff at 50 years:2.8% <50 versus 12% >50. Twenty-one strains belonged to four described subtypes, that is, 4c in eight cases, 4h in two, 4k in three, and 4r in eight. Ten strains could not be assigned to any known subtype and may represent six new variants, that is, subtype 4 in five cases and subtype 2 in one. Evolutionary analysis of subtype 4c and 4r sequences indicated a period of enhanced transmission in the mid-twentieth century probably due to iatrogenic causes. This study underlines the high genetic diversity of strains in the Republic of the Congo with nine subtypes 4 and one subtype 2.
|
Auteur(s) |
Jean-François Cantaloube
1
, Pierre Gallian
1, 2
, Amelia Bokilo
3
, François Jordier
1
, Philippe Biagini
1
, Houssam Attoui
4
, Jacques Chiaroni
1
, Philippe de Micco
1
1
ADES -
Anthropologie bio-culturelle, Droit, Ethique et Santé
( 186857 )
- Faculté de Médecine Secteur Nord 51, Boulevard Pierre Dramard 13344 MARSEILLE CEDEX 15
- France
2
UAABC -
Anthropologie Bio-Culturelle
( 942 )
- Faculté de Médecine - Secteur Nord Batiment A - CS80011 Bd Pierre Dramard 13344 MARSEILLE Cedex 15 FRANCE
- France
3
CNTS of Brazzaville
( 172722 )
- Brazzaville
- Congo-Kinshasa
4
Institute for Animal Health
( 172723 )
- Pirbright, Woking, Surre
- Royaume-Uni
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Audience |
Non spécifiée
|
Date de publication |
2010
|
Volume |
82
|
Numéro |
4
|
Page/Identifiant |
562-567
|
Domaine(s) |
|
Mots-clés |
en
HCV, Republic of the Congo, prevalence, genotyping, phylogeny, coalescence
|
DOI | 10.1002/jmv.21724 |
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