The article presents two cases of language contacts in French Guiana. This region is the home of two Amerindian languages, Kali'na and Emérillon, belonging to the Cariban and Tupi-guarani families respectively. Living near the coast, the speakers of Kali'na had earlier and more intensive contact with Portuguese, Spanish, English, Dutch and French than the Emérillon, who live deeper into the rainforest. During the last century, both languages underwent a certain amount of Francisation. Furthermore, over the whole post-Columbian period, several creole languages played a role in the interaction with other communities, both indigenous and European. The authors study the similarities and differences in the borrowing processes that are the result of all the contact situations.