During 2010-2012, excavations were conducted at the Temple of Ptah at Karnak. The work mainly focused in the southwestern part of the precinct, and inside the chapels and courtyard of the sanctuary. This preliminary report presents the traces of different developments in the environment of the temple during its long use, up to its secondary occupation after the end of the Pharaonic worship. These preliminary investigations concern: - the remains prior to construction of the sanctuary of Tuthmosis III (a gate of Senakhtenre Ahmose and massive mud-brick walls beneath the substructure of the temple); - limestone bearing slabs which were reused as the floor of the chapels and the courtyard; - limestone blocks of Tuthmosis III and Hatshepsut which were reused in the foundation of the temple; - Ptolemaic and Kushite gates associated with mud-brick enclosure walls on the main axis and on another southernmost axis; - the late Roman and secular occupation of the area.