This paper proposes an indirect measure of the resilience of regions, which mainly relates to the stability or instability of the technological mixes contributing to the centrality of regions over time. For this purpose, the study relies on the theoretical framework offered by the economic dominance theory (EDT). The empirical analysis exploits data on the patent applications filed between 2000 and 2011 at the European Patent Office (EPO) and their citations to prior patents filed at the EPO or under the Patent Cooperation Treaty (PCT).