Uptake of PrEP and condom and sexual risk behavior among MSM during the ANRS IPERGAY trial
Luis Sagaon-Teyssier
(1, 2, 3)
,
Marie Suzan-Monti
(4, 1)
,
Baptiste Demoulin
(4, 1)
,
Catherine Capitant
(5)
,
Nicolas Lorente
(4)
,
Marie Préau
(4, 6)
,
Marion Mora
(4, 1)
,
Daniela Rojas Castro
(7)
,
Christian Chidiac
(5)
,
Julie Chas
(8)
,
Laurence Meyer
(9)
,
Jean-Michel Molina
(10)
1
ORS PACA
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 IRD - Institut de Recherche pour le Développement
4 SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
5 INSERM - Institut National de la Santé et de la Recherche Médicale
6 GRePS - Groupe de Recherche en Psychologie Sociale
7 GIEMA - Grupo de Investigación en Energía y Medioambiente [Bucaramanga]]
8 CHU Tenon [AP-HP]
9 CESP - Centre de recherche en épidémiologie et santé des populations
10 Service de maladies infectieuses et tropicales [Saint-Louis]
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 IRD - Institut de Recherche pour le Développement
4 SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
5 INSERM - Institut National de la Santé et de la Recherche Médicale
6 GRePS - Groupe de Recherche en Psychologie Sociale
7 GIEMA - Grupo de Investigación en Energía y Medioambiente [Bucaramanga]]
8 CHU Tenon [AP-HP]
9 CESP - Centre de recherche en épidémiologie et santé des populations
10 Service de maladies infectieuses et tropicales [Saint-Louis]
Luis Sagaon-Teyssier
- Fonction : Auteur
- PersonId : 21132
- IdHAL : luis-sagaon-teyssier
- ORCID : 0000-0001-7318-6596
Marie Suzan-Monti
- Fonction : Auteur
- PersonId : 21154
- IdHAL : marie-suzan-monti
- ORCID : 0000-0003-2507-2863
- IdRef : 253119545
Baptiste Demoulin
- Fonction : Auteur
- PersonId : 776817
- ORCID : 0000-0002-6689-3919
Nicolas Lorente
- Fonction : Auteur
- PersonId : 765490
- ORCID : 0000-0003-0952-8031
- IdRef : 13629829X
Marie Préau
- Fonction : Auteur
- PersonId : 171105
- IdHAL : preau-marie
- ORCID : 0000-0002-6239-1671
- IdRef : 084340525
Marion Mora
- Fonction : Auteur
- PersonId : 763200
- ORCID : 0000-0001-7543-6982
Christian Chidiac
- Fonction : Auteur
- PersonId : 1062515
Laurence Meyer
- Fonction : Auteur
- PersonId : 756223
- ORCID : 0000-0001-5707-2062
- IdRef : 077686659
Résumé
The double-blind phase of the randomized ANRS IPERGAY trial, evaluating sexual activity-based oral HIV pre-exposure prophylaxis (PrEP), was conducted among high-risk men who have sex with men (MSM). Results showed an 86% (95% CI: 40–98) relative reduction in HIV incidence among
participants with tenofovir disoproxil fumarate–emtricitabine vs. placebo. The present pooled analysis aimed to analyze (i) participants’ adherence to the prescribed treatment and/or condom use during sexual intercourse and (ii) sexual behavior during the double-blind phase of the study. Four hundred MSM were enrolled in the trial. Every 2 months they completed online questionnaires collecting sexual behavior and PrEP adherence data regarding their most recent sexual intercourse. A total of 2232 questionnaires (M0–M24) were analyzed. Changes over time were evaluated using a mixed model accounting for multiple measures. Irrespective of sexual partner and practice type, on average, 42.6% (min: 32.1–max: 45.8%) reported PrEP use only during their most recent episode of sexual intercourse; 29% (22.9–35.6%) reported both PrEP and condom use; 11.7% (7.2–18.9%) reported condom-use only, and 16.7% (10.8–29.6%) reported no PrEP or condom use with no significant change during the study. Scheduled (i.e.,
correct) PrEP use was reported on average by 59.0% (47.2–68.5%) of those reporting PrEP use during their most recent sexual intercourse. Overall, 70.3% (65.3–79.4%) and 69.3% (58.3–75.4%) of participants reported, respectively, condomless anal and condomless receptive anal intercourse during their most recent sexual encounter without significant change during followup. Overall, on average 83.3% (min: 70.4–max: 89.2%) of participants protected themselves by PrEP intake or condom use or both during the trial, and no increase in at-risk sexual practices was observed. None of these indicators showed significant trend during the follow-up, although we found a tendency toward decrease (p = .19) of the median number of sexual partners strengthening the absence of behavioral disinhibition. On-demand PrEP within a comprehensive HIV prevention package could improve prevention in MSM.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
The double-blind phase of the randomized ANRS IPERGAY trial, evaluating sexual activity-based oral HIV pre-exposure prophylaxis (PrEP), was conducted among high-risk men who have sex with men (MSM). Results showed an 86% (95% CI: 40–98) relative reduction in HIV incidence among
participants with tenofovir disoproxil fumarate–emtricitabine vs. placebo. The present pooled analysis aimed to analyze (i) participants’ adherence to the prescribed treatment and/or condom use during sexual intercourse and (ii) sexual behavior during the double-blind phase of the study. Four hundred MSM were enrolled in the trial. Every 2 months they completed online questionnaires collecting sexual behavior and PrEP adherence data regarding their most recent sexual intercourse. A total of 2232 questionnaires (M0–M24) were analyzed. Changes over time were evaluated using a mixed model accounting for multiple measures. Irrespective of sexual partner and practice type, on average, 42.6% (min: 32.1–max: 45.8%) reported PrEP use only during their most recent episode of sexual intercourse; 29% (22.9–35.6%) reported both PrEP and condom use; 11.7% (7.2–18.9%) reported condom-use only, and 16.7% (10.8–29.6%) reported no PrEP or condom use with no significant change during the study. Scheduled (i.e.,
correct) PrEP use was reported on average by 59.0% (47.2–68.5%) of those reporting PrEP use during their most recent sexual intercourse. Overall, 70.3% (65.3–79.4%) and 69.3% (58.3–75.4%) of participants reported, respectively, condomless anal and condomless receptive anal intercourse during their most recent sexual encounter without significant change during followup. Overall, on average 83.3% (min: 70.4–max: 89.2%) of participants protected themselves by PrEP intake or condom use or both during the trial, and no increase in at-risk sexual practices was observed. None of these indicators showed significant trend during the follow-up, although we found a tendency toward decrease (p = .19) of the median number of sexual partners strengthening the absence of behavioral disinhibition. On-demand PrEP within a comprehensive HIV prevention package could improve prevention in MSM.
|
Titre |
en
Uptake of PrEP and condom and sexual risk behavior among MSM during the ANRS IPERGAY trial
|
Auteur(s) |
Luis Sagaon-Teyssier
1, 2, 3
, Marie Suzan-Monti
4, 1
, Baptiste Demoulin
4, 1
, Catherine Capitant
5
, Nicolas Lorente
4
, Marie Préau
4, 6
, Marion Mora
4, 1
, Daniela Rojas Castro
7
, Christian Chidiac
5
, Julie Chas
8
, Laurence Meyer
9
, Jean-Michel Molina
10
1
ORS PACA
( 300140 )
-
- France
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
3
IRD -
Institut de Recherche pour le Développement
( 67872 )
- Siège
Le Sextant
44, bd de Dunkerque
CS 90009
13572 Marseille cedex 02
- France
4
SESSTIM - U912 INSERM - Aix Marseille Univ - IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 540465 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 – Marseille Cedex 05
- France
5
INSERM -
Institut National de la Santé et de la Recherche Médicale
( 303623 )
- 101, rue de Tolbiac, 75013 Paris
- France
6
GRePS -
Groupe de Recherche en Psychologie Sociale
( 49955 )
- Université Lyon 2 - Institut de Psychologie 5 avenue Pierre Mendès-France - 69676 BRON cedex
- France
7
GIEMA -
Grupo de Investigación en Energía y Medioambiente [Bucaramanga]]
( 495537 )
- School of Mechanical Engineering, Universidad Industrial de Santander, Ciudad Universitaria, Bucaramanga
- Colombie
8
CHU Tenon [AP-HP]
( 328304 )
- 4 Rue de la Chine, 75020 Paris
- France
9
CESP -
Centre de recherche en épidémiologie et santé des populations
( 106188 )
- 16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
- France
10
Service de maladies infectieuses et tropicales [Saint-Louis]
( 25884 )
- 1, avenue Claude-Vellefaux 75010 Paris
- France
|
Audience |
Internationale
|
Date de publication |
2016
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Domaine(s) |
|
Mots-clés |
en
adherence, MSM, sexual behavior, On-demand HIV preexposure prophylaxis
|
DOI | 10.1080/09540121.2016.1146653 |
Base Horizon | fdi:010074660 |
Origine :
Publication financée par une institution
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