Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8)
Maria Patrizia Carrieri
(1)
,
Virginie Villes
(2)
,
Francois Raffi
(3)
,
Camelia Protopopescu
(1, 4)
,
Marie Preau
(5, 1)
,
Dominique Salmon
(6, 7)
,
Audrey Taieb
(8)
,
Jean-Marie Lang
(9)
,
Renaud Verdon
(10)
,
Genevieve Chene
(11)
,
Bruno Spire
(1)
1
SESSTIM - U912 INSERM - Aix Marseille Univ - IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
2 SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
3 Service des maladies infectieuses et tropicales [CHU Nantes]
4 ORS PACA
5 GRePS - Groupe de Recherche en Psychologie Sociale
6 Bureau d'Etude Technique et de Contrôle des Grands Barrages (BETCGB)
7 Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
8 IEP Rennes - Sciences Po Rennes - Institut d'études politiques de Rennes
9 CISIH CHRU Strasbourg, BP426 67091 Strasbourg Cedex 1, France
10 Unité de Maladies Infectieuses et Tropicales [CHU Caen]
11 Epidémiologie et Biostatistique [Bordeaux]
2 SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
3 Service des maladies infectieuses et tropicales [CHU Nantes]
4 ORS PACA
5 GRePS - Groupe de Recherche en Psychologie Sociale
6 Bureau d'Etude Technique et de Contrôle des Grands Barrages (BETCGB)
7 Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
8 IEP Rennes - Sciences Po Rennes - Institut d'études politiques de Rennes
9 CISIH CHRU Strasbourg, BP426 67091 Strasbourg Cedex 1, France
10 Unité de Maladies Infectieuses et Tropicales [CHU Caen]
11 Epidémiologie et Biostatistique [Bordeaux]
Maria Patrizia Carrieri
- Fonction : Auteur
- PersonId : 21176
- IdHAL : patrizia-carrieri
- ORCID : 0000-0002-6794-4837
- IdRef : 144323036
Camelia Protopopescu
- Fonction : Auteur
- PersonId : 21198
- IdHAL : camelia-protopopescu
Marie Preau
- Fonction : Auteur
- PersonId : 171105
- IdHAL : preau-marie
- ORCID : 0000-0002-6239-1671
- IdRef : 084340525
Bruno Spire
- Fonction : Auteur
- PersonId : 21429
- IdHAL : cheick-haiballa-kounta
- ORCID : 0000-0001-6800-0742
Résumé
The introduction of potent anti-retroviral treatment (ART) has transformed HIV disease into a chronic condition with the prospect, for the patient, of strict adherence to effective but lifelong treatments. Within this framework, a major issue that can negatively affect adherence is the side-effects of the treatment. To date, studies documenting how individuals HIV-infected through drug injection (IDUs) experience ART-related side effects are sparse. Longitudinal data collected from the APROCO-COPILOTE cohort have been used to compare the experience of ART-related side-effects who have been HIV-infected via injecting drug use and non-IDU patients. A 20-item list was used to collect self-reported side-effects over a 7-year follow up period. Of 922 patients, 15% were IDUs. At any given visit, IDUs reported a significantly higher number of side-effects and had approximately twice the risk of reporting any side effect than non-IDUs. Most commonly reported side-effects were dry skin, fatigue, vomiting, bone troubles, insomnia. After adjustment for social conditions, depressive symptoms, use of sleeping pills and time since HIV diagnosis, IDUs reported experiencing significantly more side-effects than non-IDUs. Whether or not this is related to sensitivity to pain or to other comorbidities is difficult to establish. Further research is needed to understand how substitution treatment can mediate the relationship between exposure to opioids and side-effects. Providing appropriate care to reduce side-effects, thereby increasing adherence to ART in this population, remains a major challenge especially in those countries scaling up ART. Incorporating symptom management and improving access to analgesic medications within a model of comprehensive care for HIV-infected IDUs, could reduce the impact of drug-related and HIV-related harms and induce better long-term treatment outcomes and quality of life.
Domaines
PsychologieFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Self-reported side-effects of anti-retroviral treatment among IDUs: A 7-year longitudinal study (APROCO-COPILOTE COHORT ANRS CO-8)
|
Résumé |
en
The introduction of potent anti-retroviral treatment (ART) has transformed HIV disease into a chronic condition with the prospect, for the patient, of strict adherence to effective but lifelong treatments. Within this framework, a major issue that can negatively affect adherence is the side-effects of the treatment. To date, studies documenting how individuals HIV-infected through drug injection (IDUs) experience ART-related side effects are sparse. Longitudinal data collected from the APROCO-COPILOTE cohort have been used to compare the experience of ART-related side-effects who have been HIV-infected via injecting drug use and non-IDU patients. A 20-item list was used to collect self-reported side-effects over a 7-year follow up period. Of 922 patients, 15% were IDUs. At any given visit, IDUs reported a significantly higher number of side-effects and had approximately twice the risk of reporting any side effect than non-IDUs. Most commonly reported side-effects were dry skin, fatigue, vomiting, bone troubles, insomnia. After adjustment for social conditions, depressive symptoms, use of sleeping pills and time since HIV diagnosis, IDUs reported experiencing significantly more side-effects than non-IDUs. Whether or not this is related to sensitivity to pain or to other comorbidities is difficult to establish. Further research is needed to understand how substitution treatment can mediate the relationship between exposure to opioids and side-effects. Providing appropriate care to reduce side-effects, thereby increasing adherence to ART in this population, remains a major challenge especially in those countries scaling up ART. Incorporating symptom management and improving access to analgesic medications within a model of comprehensive care for HIV-infected IDUs, could reduce the impact of drug-related and HIV-related harms and induce better long-term treatment outcomes and quality of life.
|
Auteur(s) |
Maria Patrizia Carrieri
1
, Virginie Villes
2
, Francois Raffi
3
, Camelia Protopopescu
1, 4
, Marie Preau
5, 1
, Dominique Salmon
6, 7
, Audrey Taieb
8
, Jean-Marie Lang
9
, Renaud Verdon
10
, Genevieve Chene
11
, Bruno Spire
1
1
SESSTIM - U912 INSERM - Aix Marseille Univ - IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 540465 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 – Marseille Cedex 05
- France
2
SPMC -
Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
( 233198 )
- Laboratoire de Santé Publique - 27 bd Jean Moulin 13385 Marseille 05
- France
3
Service des maladies infectieuses et tropicales [CHU Nantes]
( 204727 )
- CHU Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France
- France
4
ORS PACA
( 300140 )
-
- France
5
GRePS -
Groupe de Recherche en Psychologie Sociale
( 49955 )
- Université Lyon 2 - Institut de Psychologie 5 avenue Pierre Mendès-France - 69676 BRON cedex
- France
6
Bureau d'Etude Technique et de Contrôle des Grands Barrages (BETCGB)
( 499893 )
- France
7
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
( 189806 )
- 27, rue du Faubourg Saint-Jacques 75014 Paris
- France
8
IEP Rennes -
Sciences Po Rennes - Institut d'études politiques de Rennes
( 45379 )
- 104, boulevard de la Duchesse Anne - 35700 Rennes
- France
9
CISIH CHRU Strasbourg, BP426 67091 Strasbourg Cedex 1, France
( 501565 )
10
Unité de Maladies Infectieuses et Tropicales [CHU Caen]
( 42519 )
- Centre Hospitalier Universitaire
Avenue de la Côte de Nacre
CS 30001
14033 CAEN cedex 9
- France
11
Epidémiologie et Biostatistique [Bordeaux]
( 55677 )
- 146, rue Léo-Saignat 33076 Bordeaux
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2007
|
Volume |
18
|
Page/Identifiant |
288 - 295
|
Domaine(s) |
|
Mots-clés |
en
Side effects, Anti-retroviral treatment, HIV, Injecting drug users, Hyperalgesia, Pain
|
DOI | 10.1016/j.drugpo.2007.01.014 |
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