Article dans une revue
BMJ Global Health
Année : 2017
Impact of a malaria intervention package in schools on Plasmodium infection, anaemia and cognitive function in schoolchildren in Mali: a pragmatic cluster-randomised trial
Background : School-aged children are rarely targeted by malaria control programmes, yet the prevalence of Plasmodium infection in primary school children often exceeds that seen in younger children and could affect haemoglobin concentration and school performance.
Methods : A cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs). Control schools received LLINs as part of the national universal net distribution programme. The impact of the interventions on malaria and anaemia was evaluated over 20 months using cross-sectional surveys in a random subset of 38 schools(all classes), with a range of cognitive measures (sustained attention, visual search, numeracy, vocabulary and writing) assessed in a longitudinal cohort of children aged 9–12 years in all 80 schools.
Background : School-aged children are rarely targeted by malaria control programmes, yet the prevalence of Plasmodium infection in primary school children often exceeds that seen in younger children and could affect haemoglobin concentration and school performance.
Methods : A cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs). Control schools received LLINs as part of the national universal net distribution programme. The impact of the interventions on malaria and anaemia was evaluated over 20 months using cross-sectional surveys in a random subset of 38 schools(all classes), with a range of cognitive measures (sustained attention, visual search, numeracy, vocabulary and writing) assessed in a longitudinal cohort of children aged 9–12 years in all 80 schools.
Titre
en
Impact of a malaria intervention package in schools on Plasmodium infection, anaemia and cognitive function in schoolchildren in Mali: a pragmatic cluster-randomised trial
1
Faculty of Infectious and Tropical Diseases
( 415776 )
- Royaume-Uni
London School of Hygiene and Tropical Medicine ( 353798 )
2
Save the Children, Bamako, Mali
( 549226 )
- Mali
3
INSP -
Institut National de Santé Publique [Bamako] = National Institute of Research on Public Health
( 549227 )
- Rue Cabral, Porte 40 Hypodrome Bamako BP 1771, Bamako
- Mali
4
Ministry of Health, Programme National de Lutte contre le Paludisme, Mali
( 549228 )
- Mali
5
National Institute for Environmental Health Sciences Research Triangle Park
( 56645 )
- NC
- États-Unis
National Institute for Environmental Health Sciences Research Triangle Park ( 313240 )
6
CES -
Centre d'économie de la Sorbonne
( 15080 )
- Maison des Sciences Économiques - 106-112 Boulevard de l'Hôpital - 75647 Paris Cedex 13
- France
Université Paris 1 Panthéon-Sorbonne UMR8174 ( 7550 )
;
Centre National de la Recherche Scientifique UMR8174 ( 441569 )
Siân Clarke, Saba Rouhani, Seybou Diarra, Renion Saye, Modibo Bamadio, et al.. Impact of a malaria intervention package in schools on Plasmodium infection, anaemia and cognitive function in schoolchildren in Mali: a pragmatic cluster-randomised trial. BMJ Global Health, 2017, 2 (2), pp.e000182. ⟨10.1136/bmjgh-2016-000182⟩. ⟨halshs-01674689⟩