Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study
Patricia Marino
(1)
,
Rajae Touzani
(1)
,
Lionel Perrier
(2)
,
Etienne Rouleau
(3)
,
Dede Sika Kossi
(4)
,
Zou Zhaomin
(5)
,
Nathanaël Charrier
(6)
,
Nicolas Goardon
(7)
,
Claude Preudhomme
(8, 9)
,
Isabelle Durand-Zaleski
(6)
,
Isabelle Borget
(5)
,
Sandrine Baffert
(4)
,
Lucie Coppin
(9)
,
Julie Leclerc
(9)
,
Marie-Francoise Odou
(10)
1
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
2 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
3 Département de biologie et pathologie médicales [Gustave Roussy]
4 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
5 Etudes et Recherche en économie de la santé
6 URC Eco - Unité de recherche clinique en économie de la santé d'Ile-de-France
7 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
8 Centre de Biologie et de Pathologie - Laboratoire d'Hématologie [CHRU Lille]
9 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
10 LIRIC - Lille Inflammation Research International Center - U 995
2 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
3 Département de biologie et pathologie médicales [Gustave Roussy]
4 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
5 Etudes et Recherche en économie de la santé
6 URC Eco - Unité de recherche clinique en économie de la santé d'Ile-de-France
7 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
8 Centre de Biologie et de Pathologie - Laboratoire d'Hématologie [CHRU Lille]
9 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
10 LIRIC - Lille Inflammation Research International Center - U 995
Patricia Marino
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 21175
- IdHAL : patricia-marino
Connectez-vous pour contacter l'auteur
Rajae Touzani
- Fonction : Auteur
- PersonId : 21075
- IdHAL : rajae-touzani
- ORCID : 0000-0002-2713-0943
- IdRef : 253128595
Lionel Perrier
- Fonction : Auteur
- PersonId : 15600
- IdHAL : lionel-perrier
- ORCID : 0000-0003-4487-8723
- IdRef : 060772239
Etienne Rouleau
- Fonction : Auteur
- PersonId : 889842
Claude Preudhomme
- Fonction : Auteur
- PersonId : 899523
Sandrine Baffert
- Fonction : Auteur
- PersonId : 972662
Lucie Coppin
- Fonction : Collaborateur
Julie Leclerc
- Fonction : Collaborateur
Marie-Francoise Odou
- Fonction : Collaborateur
Résumé
It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels' tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top-down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607€ (±207) in somatic genetics and 550€ (±140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30-32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis.
Domaines
Economies et financesFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels' tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top-down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607€ (±207) in somatic genetics and 550€ (±140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30-32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis.
|
Titre |
en
Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study
|
Auteur(s) |
Patricia Marino
1
, Rajae Touzani
1
, Lionel Perrier
2
, Etienne Rouleau
3
, Dede Sika Kossi
4
, Zou Zhaomin
5
, Nathanaël Charrier
6
, Nicolas Goardon
7
, Claude Preudhomme
8, 9
, Isabelle Durand-Zaleski
6
, Isabelle Borget
5
, Sandrine Baffert
4
, Lucie Coppin
9
, Julie Leclerc
9
, Marie-Francoise Odou
10
1
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
2
GATE Lyon Saint-Étienne -
Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
( 102550 )
- 93, chemin des Mouilles 69130 Écully
6, rue Basse des Rives 42023 Saint-Étienne cedex 02
- France
3
Département de biologie et pathologie médicales [Gustave Roussy]
( 150180 )
- Gustave Roussy. 114, rue Édouard-Vaillant 94805 Villejuif Cedex -France
- France
4
Fondation Ophtalmologique Adolphe de Rothschild [Paris]
( 452220 )
- 29 rue Manin - 75019 Paris
- France
5
Etudes et Recherche en économie de la santé
( 554076 )
- France
6
URC Eco -
Unité de recherche clinique en économie de la santé d'Ile-de-France
( 506958 )
- Galerie B1 - 3ème étage - 1 Place du Parvis Notre Dame 75004 Paris.
- France
7
UNICANCER/CRLC -
Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
( 301261 )
- 3 avenue général Harris, 14000 Caen
- France
8
Centre de Biologie et de Pathologie -
Laboratoire d'Hématologie [CHRU Lille]
( 536232 )
- France
9
JPArc -
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
( 545691 )
- Faculté de Médecine Henri Warembourg - Pôle Recherche - 1 place de verdun 59045 Lille cedex.
- France
10
LIRIC -
Lille Inflammation Research International Center - U 995
( 498252 )
- Faculté de médecine -
Pôle recherche-4ème étage -
Place de Verdun -
F-59045 Lille Cedex -
- France
|
Volume |
26
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2018
|
Numéro |
3
|
Page/Identifiant |
pp. 314-323
|
Domaine(s) |
|
Financement |
|
Collaboration/Projet |
|
DOI | 10.1038/s41431-017-0081-3 |
Pubmed Id | 29367707 |
PubMed Central | PMC5838982 |
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