Acceptability of HIV cure-related trials: the challenges for physicians and people living with HIV (ANRS-APSEC)
Marie Preau
(1)
,
Marjolaine Doumergue
(1)
,
Christel Protière
(2)
,
Cecile Goujard
(3)
,
Marion Mora
(2)
,
Laurence Meyer
(4)
,
Jean-Daniel Lelièvre
(5)
,
François Raffi
(6)
,
Bruno Spire
(2)
,
Olivier Lambotte
(7, 8)
,
Marie Suzan-Monti
(2)
1
GRePS -
Groupe de Recherche en Psychologie Sociale
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 Hôpital Bicêtre
4 BMNST - Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
5 IMRB - Institut Mondor de Recherche Biomédicale
6 Maladies infectieuses et tropicales
7 Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre]
8 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 Hôpital Bicêtre
4 BMNST - Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
5 IMRB - Institut Mondor de Recherche Biomédicale
6 Maladies infectieuses et tropicales
7 Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre]
8 IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes
Marie Preau
- Fonction : Auteur
- PersonId : 171105
- IdHAL : preau-marie
- ORCID : 0000-0002-6239-1671
- IdRef : 084340525
Marjolaine Doumergue
- Fonction : Auteur
- PersonId : 172698
- IdHAL : marjolaine-doumergue
- ORCID : 0000-0003-3060-4529
- IdRef : 197233546
Christel Protière
- Fonction : Auteur
- PersonId : 21097
- IdHAL : christel-protiere
- ORCID : 0000-0002-5602-9617
- IdRef : 077935489
Marion Mora
- Fonction : Auteur
- PersonId : 763200
- ORCID : 0000-0001-7543-6982
Laurence Meyer
- Fonction : Auteur
- PersonId : 1068367
- ORCID : 0000-0002-6113-936X
- IdRef : 080229409
Jean-Daniel Lelièvre
- Fonction : Auteur
- PersonId : 759950
- ORCID : 0000-0002-8182-3628
- IdRef : 074657313
Bruno Spire
- Fonction : Auteur
- PersonId : 21429
- IdHAL : cheick-haiballa-kounta
- ORCID : 0000-0001-6800-0742
Marie Suzan-Monti
- Fonction : Auteur
- PersonId : 21154
- IdHAL : marie-suzan-monti
- ORCID : 0000-0003-2507-2863
- IdRef : 253119545
Résumé
Essential HIV cure-related clinical trials (HCRCT) have a potentially high-risk profile in terms of participants' health, which could hinder enrollment by people living with HIV (PLWH) and healthcare professionals (HP). The ANRS-APSEC survey is part of the IAS "Towards an HIV cure" initiative, which promotes multidisciplinary research for a safe, affordable and scalable cure. The study objectives were to understand the psychosocial mechanisms underlying PLWH and HP viewpoints about future HCRCT. Six focus group discussions (three with PLWH (n = 21) and three with HP (n = 30)) were held in three French infectious disease units. From these, three perspectives on HCRCT were identified. The first involved beliefs and knowledge associating HCRCT with poorer health and quality of life for PLWH. The second concerned perceptions of HCRCT as a biological and epidemiological flashback to a situation when HIV infection was left uncontrolled. The third was characterized by aspects of historical HIV culture that embrace innovation.
Domaines
PsychologieFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Acceptability of HIV cure-related trials: the challenges for physicians and people living with HIV (ANRS-APSEC)
|
Résumé |
en
Essential HIV cure-related clinical trials (HCRCT) have a potentially high-risk profile in terms of participants' health, which could hinder enrollment by people living with HIV (PLWH) and healthcare professionals (HP). The ANRS-APSEC survey is part of the IAS "Towards an HIV cure" initiative, which promotes multidisciplinary research for a safe, affordable and scalable cure. The study objectives were to understand the psychosocial mechanisms underlying PLWH and HP viewpoints about future HCRCT. Six focus group discussions (three with PLWH (n = 21) and three with HP (n = 30)) were held in three French infectious disease units. From these, three perspectives on HCRCT were identified. The first involved beliefs and knowledge associating HCRCT with poorer health and quality of life for PLWH. The second concerned perceptions of HCRCT as a biological and epidemiological flashback to a situation when HIV infection was left uncontrolled. The third was characterized by aspects of historical HIV culture that embrace innovation.
|
Auteur(s) |
Marie Preau
1
, Marjolaine Doumergue
1
, Christel Protière
2
, Cecile Goujard
3
, Marion Mora
2
, Laurence Meyer
4
, Jean-Daniel Lelièvre
5
, François Raffi
6
, Bruno Spire
2
, Olivier Lambotte
7, 8
, Marie Suzan-Monti
2
1
GRePS -
Groupe de Recherche en Psychologie Sociale
( 49955 )
- Université Lyon 2 - Institut de Psychologie 5 avenue Pierre Mendès-France - 69676 BRON cedex
- France
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
3
Hôpital Bicêtre
( 29312 )
- 78, rue du Général Leclerc 94275 Le Kremlin-Bicêtre
- France
4
BMNST -
Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
( 223038 )
- 11 rue Humann - Bâtiment 3 - 67000 Strasbourg
- France
5
IMRB -
Institut Mondor de Recherche Biomédicale
( 266797 )
- 8 rue du Général Sarrail 94010 Créteil
- France
6
Maladies infectieuses et tropicales
( 178763 )
- Nantes
- France
7
Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre]
( 487755 )
- 78 Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre.
- France
8
IMVA - U1184 -
Immunologie des Maladies Virales et Autoimmunes
( 421311 )
- Site de l'Hôpital de Bicêtre - Faculté de Médecine Paris Sud - 63 rue Gabriel Péri 94276 Le Kremlin-Bicêtre Cedex.
Site du CEA de Fontenay-aux-Roses - 10, route du Panorama - BP 6 - 92265 Fontenay-aux-Roses.
- France
|
Volume |
30
|
Numéro |
7
|
Page/Identifiant |
914-920
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Date de publication |
2018-01-18
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
France, HIV history, Willingness to participate in clinical trials, cure trial
|
DOI | 10.1080/09540121.2018.1426825 |
Pubmed Id | 29347826 |
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