Big Data as pervasive, disruptive, and innovation-driven technology are now a hot topic in academic and business fields. In particular, the healthcare industry is one of those most exposed to the organizational changes produced by the Big Data and Born Digital Data phenomena. Healthcare organizations have to adapt their organizations to manage an ever increasing amount of data affecting their ability to deliver high quality services that must be both effective and efficient. We advance that the Technology Affordance theory can be used to explain how information technology is involved in organizational changes. The paper highlights the importance of an Affordance-Based Theory used to explain this particular issue.