Feasibility of an exercise and nutritional intervention for weight management during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial
Aude-Marie Foucaut
(1, 2)
,
Magali Morelle
(3, 1)
,
Anne-Sophie Kempf-Lépine
(1)
,
Cédric Baudinet
(1)
,
Renaud Meyrand
(1)
,
Séverine Guillemaut
(1)
,
Séverine Metzger
(1)
,
Valérie Bourne-Branchu
(1)
,
Elodie Grinand
(1)
,
Sylvie Chabaud
(1)
,
David Pérol
(1)
,
Julien Carretier
(1)
,
Sophie Berthouze
(4)
,
Eric Reynes
(5)
,
Lionel Perrier
(3, 1)
,
Paul Rebattu
(1)
,
Pierre-Étienne Heudel
(1)
,
Thomas Bachelot
(1)
,
Patrick Bachmann
(1)
,
Béatrice Fervers
(1)
,
Olivier Trédan
(1)
,
Marina Touillaud
(6, 1)
1
Centre Léon Bérard [Lyon]
2 LEPS - Laboratoire éducations et promotion de la santé
3 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
4 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
5 L-VIS - Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428)
6 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
2 LEPS - Laboratoire éducations et promotion de la santé
3 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
4 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité
5 L-VIS - Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428)
6 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
Aude-Marie Foucaut
- Fonction : Auteur
- PersonId : 1213314
- IdHAL : aude-marie-foucaut
- ORCID : 0000-0002-4258-1355
Magali Morelle
- Fonction : Auteur
- PersonId : 182509
- IdHAL : magali-morelle
- ORCID : 0000-0002-4694-4918
- IdRef : 253123240
Eric Reynes
- Fonction : Auteur
- PersonId : 180143
- IdHAL : ericreynes
- ORCID : 0000-0002-0237-0166
Lionel Perrier
- Fonction : Auteur
- PersonId : 15600
- IdHAL : lionel-perrier
- ORCID : 0000-0003-4487-8723
- IdRef : 060772239
Thomas Bachelot
- Fonction : Auteur
- PersonId : 757054
- ORCID : 0000-0002-0866-9484
- IdRef : 088209970
Béatrice Fervers
- Fonction : Auteur
- PersonId : 969134
- ORCID : 0000-0003-3498-6499
Olivier Trédan
- Fonction : Auteur
- PersonId : 767637
- ORCID : 0000-0001-5881-9383
Marina Touillaud
- Fonction : Auteur
- PersonId : 780565
- ORCID : 0000-0001-9900-5861
Résumé
PURPOSE: Lack of physical activity (PA), weight gain, and overweight have been associated with increased risk of recurrence and mortality after breast cancer diagnosis. We evaluated the feasibility of implementing an individualized exercise program and nutritional counseling during adjuvant treatment of localized invasive breast cancer. METHODS: Sixty-one patients eligible for adjuvant chemotherapy were randomized 2:1 to receive a 6-month program of weekly aerobic exercises associated with nutritional counseling (n = 41) or usual care with nutritional counseling (n = 20, one withdrawal). The primary endpoints were the proportion of patients compliant with two weekly supervised sessions and their overall adherence (i.e., proportion of supervised and unsupervised sessions completed versus planned sessions). RESULTS: Ten percent of patients in the intervention group were compliant with the two weekly supervised sessions for 6 months, but the overall median adherence rate was 85% of supervised and non-supervised sessions completed. Non-adherence was mainly due to intrinsic reasons (medical, organizational, psychological barriers). Adherence was positively associated with education and baseline PA level and inversely associated with baseline weight and tumor grade. No statistically significant benefits were observed in the intervention group, even if overall PA level and body composition improved and anthropometrics were maintained over time (p \textless 0.05). CONCLUSIONS: Overall, there was good adherence with the 6-month exercise program during adjuvant treatment for breast cancer, despite poor compliance to twice-weekly supervised sessions. This study highlights the need for flexible exercise modalities and innovative experimental design to reach patients who would most adhere and benefit from intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01331772. Registered 8 April 2011, https://clinicaltrials.gov/ct2/show/NCT01331772?term=pasapas&rank=1.
Domaines
Economies et financesFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
PURPOSE: Lack of physical activity (PA), weight gain, and overweight have been associated with increased risk of recurrence and mortality after breast cancer diagnosis. We evaluated the feasibility of implementing an individualized exercise program and nutritional counseling during adjuvant treatment of localized invasive breast cancer. METHODS: Sixty-one patients eligible for adjuvant chemotherapy were randomized 2:1 to receive a 6-month program of weekly aerobic exercises associated with nutritional counseling (n = 41) or usual care with nutritional counseling (n = 20, one withdrawal). The primary endpoints were the proportion of patients compliant with two weekly supervised sessions and their overall adherence (i.e., proportion of supervised and unsupervised sessions completed versus planned sessions). RESULTS: Ten percent of patients in the intervention group were compliant with the two weekly supervised sessions for 6 months, but the overall median adherence rate was 85% of supervised and non-supervised sessions completed. Non-adherence was mainly due to intrinsic reasons (medical, organizational, psychological barriers). Adherence was positively associated with education and baseline PA level and inversely associated with baseline weight and tumor grade. No statistically significant benefits were observed in the intervention group, even if overall PA level and body composition improved and anthropometrics were maintained over time (p \textless 0.05). CONCLUSIONS: Overall, there was good adherence with the 6-month exercise program during adjuvant treatment for breast cancer, despite poor compliance to twice-weekly supervised sessions. This study highlights the need for flexible exercise modalities and innovative experimental design to reach patients who would most adhere and benefit from intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01331772. Registered 8 April 2011, https://clinicaltrials.gov/ct2/show/NCT01331772?term=pasapas&rank=1.
|
Titre |
en
Feasibility of an exercise and nutritional intervention for weight management during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial
|
Auteur(s) |
Aude-Marie Foucaut
1, 2
, Magali Morelle
3, 1
, Anne-Sophie Kempf-Lépine
1
, Cédric Baudinet
1
, Renaud Meyrand
1
, Séverine Guillemaut
1
, Séverine Metzger
1
, Valérie Bourne-Branchu
1
, Elodie Grinand
1
, Sylvie Chabaud
1
, David Pérol
1
, Julien Carretier
1
, Sophie Berthouze
4
, Eric Reynes
5
, Lionel Perrier
3, 1
, Paul Rebattu
1
, Pierre-Étienne Heudel
1
, Thomas Bachelot
1
, Patrick Bachmann
1
, Béatrice Fervers
1
, Olivier Trédan
1
, Marina Touillaud
6, 1
1
Centre Léon Bérard [Lyon]
( 20549 )
- 28, rue Laennec 69373 LYON Cedex 08
- France
2
LEPS -
Laboratoire éducations et promotion de la santé
( 1001061 )
- UFR de Santé, Médecine et Biologie Humaine Université Paris 13 Campus de Bobigny 74 rue Marcel Cachin 93017 Bobigny cedex
- France
3
GATE Lyon Saint-Étienne -
Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
( 102550 )
- 93, chemin des Mouilles 69130 Écully
6, rue Basse des Rives 42023 Saint-Étienne cedex 02
- France
4
LIBM -
Laboratoire Interuniversitaire de Biologie de la Motricité
( 93721 )
- Faculté de Médecin Campus Santé Innovations - Bâtiment IRMIS - 10 rue de la Marandière 42270 Saint Priest en Jarez
Université Savoie Mont Blanc - Campus Scientifique - 73370 Le Bourget du Lac
UFR STAPS - Université Claude Bernard Lyon I - 27/29 Boulevard du 11 novembre 1918 - 69622 Villeurbanne Cedex
- France
5
L-VIS -
Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428)
( 467884 )
- Campus LyonTech-la Doua
Bâtiment R. Dubois
27-29 Boulevard du 11 novembre 1918
69622 VILLEURBANNE Cedex
- France
6
UNICANCER/CRCL -
Centre de Recherche en Cancérologie de Lyon
( 139829 )
- 28, rue Laennec - 69373 Lyon
- France
|
Page/Identifiant |
pp. 3449-3461
|
Numéro |
9
|
Date de publication électronique |
2019
|
Volume |
27
|
Date de publication |
2019
|
Audience |
Internationale
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
Breast cancer, Physical activity, Obesity, Clinical trial, Exercise, Nutrition
|
DOI | 10.1007/s00520-019-4658-y |
Pubmed Id | 30680617 |
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