Partial or total horizontal evacuation of populations in urban areas is an important protection measure against a natural or technological risk. However, casualties during massive displacement in a context of stress and in a potentially degraded environment may be high due to non-compliance with instructions, accidents, traffic jams, incivilities, lack of preparation of civil security or increased exposure to hazards. Working in evacuation plans is therefore fundamental in avoiding casualties caused by improvisation and in promoting self-evacuation whenever possible. Since it is impossible to recreate the conditions of a crisis on the ground to assess such evacuation plans, there is a need for realistic models in order to evaluate them using simulations. In this paper, we present the ESCAPE software framework that helps in the development of such plans and testing them. In particular, ESCAPE, which uses the GAMA open-source platform as a core component, provides an agent-based simulation tool that supports simulation of the evacuation of a city's population at fine temporal and geographical scales. The framework was developed such that it works for a wide range of scenarios, both in terms of hazards, geographical configurations, individual behaviors and crisis management. In order to show its adaptability, two applications are presented, one concerning the evacuation of the city of Rouen (France) in the context of a technological hazard and the other pertaining to the evacuation of the district of Hanoi (Vietnam) in the event of floods.