Cruise tourism is an obviously global industry in different dimensions. From a geographical perspective, cruise ships are mobile and capable of being repositioned at a company’s notice, which forms the inherent basis for its global spatial layout. As a branch of the cruise industry, the world cruise is clearly globalizing in geographical space by offering long itinerary, even round-the-world trips, for everyone. Using the schedule data from 2018 to 2019, this paper analyzes the spatial characteristics of the itinerary and port organization of Cunard, a world cruise company. We find that the itinerary distribution and port organization of Cunard are both globalization and regionalization, and the latter is the core and main component of the former. Under the influence of the COVID-19 epidemic, the global mobility of cruises has ground to a halt, while local mobility offers the possibility of its resumption as soon as possible. Turning to the regional voyage with the shorter and simple itinerary is feasible for Cunard and other world cruises, which is conducive to the realization of the resuming voyage as soon as possible. Moreover, strict boarding and safety onboard are essential.