This chapter focuses on the monetary politics adopted by the first independent Hellenistic rulers of Central Asia during the third century BCE, at a time when they seceded from Seleukid authority. Based upon recent research and die-studies, we discuss the main features of the coinages struck by Diodotos I, Diodotos II and Euthydemos I, the first three kings of the Graeco-Bactrian kingdom. This chapter also addresses essential problems, such as the interpretation of monograms, and questions related to quantification.