Spatial mismatch relates the unemployment and poverty of vulnerable population groups to their remoteness from job opportunities. Although the intuition initially applied to African Americans in US inner cities, spatial mismatch has a broader validity beyond the sole US context. In light of a detailed presentation of the mechanisms at work, we present the main results from various empirical tests of the spatial mismatch theory. Since key aspects of that theory remain to be tested, we also discuss methodological approaches and provide guidance for further research. We derive lessons for policy implications and comment on the appropriateness of related urban policies.