Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial
Lidia Delrieu
,
Agnès Martin
,
Marina Touillaud
,
Olivia Pérol
,
Magali Morelle
(1)
,
Olivia Febvey-Combes
,
Damien Freyssenet
,
Christine Friedenreich
,
Armelle Dufresne
,
Thomas Bachelot
,
Pierre-Etienne Heudel
,
Olivier Trédan
,
Hugo Crochet
,
Amine Bouhamama
,
Frank Pilleul
,
Vincent Pialoux
,
Béatrice Fervers
Lidia Delrieu
- Fonction : Auteur
- PersonId : 783628
- ORCID : 0000-0003-1240-5390
Agnès Martin
- Fonction : Auteur
- PersonId : 801413
- ORCID : 0000-0003-0297-1823
Marina Touillaud
- Fonction : Auteur
- PersonId : 780565
- ORCID : 0000-0001-9900-5861
Olivia Pérol
- Fonction : Auteur
- PersonId : 782321
- ORCID : 0000-0002-7543-7050
Magali Morelle
- Fonction : Auteur
- PersonId : 182509
- IdHAL : magali-morelle
- ORCID : 0000-0002-4694-4918
- IdRef : 253123240
Olivia Febvey-Combes
- Fonction : Auteur
- PersonId : 792721
- ORCID : 0000-0002-4888-0815
Damien Freyssenet
- Fonction : Auteur
- PersonId : 1138982
- ORCID : 0000-0002-6130-8207
Christine Friedenreich
- Fonction : Auteur
- PersonId : 804579
- ORCID : 0000-0002-4783-1966
- IdRef : 149329563
Armelle Dufresne
- Fonction : Auteur
- PersonId : 762479
- ORCID : 0000-0002-6637-3526
Thomas Bachelot
- Fonction : Auteur
- PersonId : 757054
- ORCID : 0000-0002-0866-9484
- IdRef : 088209970
Pierre-Etienne Heudel
- Fonction : Auteur
- PersonId : 792988
- ORCID : 0000-0002-8555-8921
Olivier Trédan
- Fonction : Auteur
- PersonId : 767637
- ORCID : 0000-0001-5881-9383
Hugo Crochet
- Fonction : Auteur
- PersonId : 1290100
- IdHAL : hugocrochet
- ORCID : 0000-0002-9800-0986
Amine Bouhamama
- Fonction : Auteur
- PersonId : 1077683
- ORCID : 0000-0003-0655-6678
Frank Pilleul
- Fonction : Auteur
Vincent Pialoux
- Fonction : Auteur
- PersonId : 1098190
- ORCID : 0000-0003-2057-061X
Béatrice Fervers
- Fonction : Auteur
- PersonId : 969134
- ORCID : 0000-0003-3498-6499
Résumé
Abstract Purpose Sarcopenia has been identified as an important prognostic factor for patients with cancer. This study aimed at exploring the potential associations between a 6-month physical activity intervention and muscle characteristics, sarcopenia, oxidative stress and toxicities in patients with metastatic breast cancer. Methods Women newly diagnosed with metastatic breast cancer ( N = 49) participated in an unsupervised, personalized, 6-month physical activity intervention with activity tracker. Computerized tomography images at the third lumbar vertebra were analysed at baseline, three months and six months to assess sarcopenia (muscle mass index < 40 cm 2 /m 2 ) and muscle quality (poor if muscle attenuation < 37.8 Hounsfield Units). Oxidative markers included plasma antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase activities), prooxidant enzymes (NADPH oxidase and myeloperoxidase activities) and oxidative stress damage markers (advanced oxidation protein products, malondialdehyde (MDA) and DNA oxidation. Results At baseline 53% (mean age 55 years (SD 10.41)) were sarcopenic and 75% had poor muscle quality. Muscle cross sectional area, skeletal muscle radiodensity, lean body mass remained constant over the six months ( p = 0.75, p = 0.07 and p = 0.75 respectively), but differed significantly between sarcopenic and non-sarcopenic patients at baseline and 6-months. Sarcopenic patients at baseline were more likely to have an increase of MDA ( p = 0.02) at 6 months. Being sarcopenic during at least one moment during the 6-month study was associated with a higher risk of developing severe toxicities (grade > 2) ( p = 0.02). Conclusions This study suggests potential benefits of physical activity for maintenance of muscle mass. Sarcopenia can alter many parameters and disturb the pro and antioxidant balance.
Domaines
Sciences de l'Homme et SociétéFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial
|
Résumé |
en
Abstract Purpose Sarcopenia has been identified as an important prognostic factor for patients with cancer. This study aimed at exploring the potential associations between a 6-month physical activity intervention and muscle characteristics, sarcopenia, oxidative stress and toxicities in patients with metastatic breast cancer. Methods Women newly diagnosed with metastatic breast cancer ( N = 49) participated in an unsupervised, personalized, 6-month physical activity intervention with activity tracker. Computerized tomography images at the third lumbar vertebra were analysed at baseline, three months and six months to assess sarcopenia (muscle mass index < 40 cm 2 /m 2 ) and muscle quality (poor if muscle attenuation < 37.8 Hounsfield Units). Oxidative markers included plasma antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase activities), prooxidant enzymes (NADPH oxidase and myeloperoxidase activities) and oxidative stress damage markers (advanced oxidation protein products, malondialdehyde (MDA) and DNA oxidation. Results At baseline 53% (mean age 55 years (SD 10.41)) were sarcopenic and 75% had poor muscle quality. Muscle cross sectional area, skeletal muscle radiodensity, lean body mass remained constant over the six months ( p = 0.75, p = 0.07 and p = 0.75 respectively), but differed significantly between sarcopenic and non-sarcopenic patients at baseline and 6-months. Sarcopenic patients at baseline were more likely to have an increase of MDA ( p = 0.02) at 6 months. Being sarcopenic during at least one moment during the 6-month study was associated with a higher risk of developing severe toxicities (grade > 2) ( p = 0.02). Conclusions This study suggests potential benefits of physical activity for maintenance of muscle mass. Sarcopenia can alter many parameters and disturb the pro and antioxidant balance.
|
Auteur(s) |
Lidia Delrieu
, Agnès Martin
, Marina Touillaud
, Olivia Pérol
, Magali Morelle
1
, Olivia Febvey-Combes
, Damien Freyssenet
, Christine Friedenreich
, Armelle Dufresne
, Thomas Bachelot
, Pierre-Etienne Heudel
, Olivier Trédan
, Hugo Crochet
, Amine Bouhamama
, Frank Pilleul
, Vincent Pialoux
, Béatrice Fervers
1
GATE -
Health System Analysis Laboratory
( 199519 )
- Université de Lyon - Ecully
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2021-08
|
Volume |
188
|
Numéro |
3
|
Page/Identifiant |
601-613
|
Domaine(s) |
|
DOI | 10.1007/s10549-021-06238-z |
PubMed Central | PMC8272711 |
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