Abstract We analyse the expected characteristics of drought events in northern Italy for baseline (1971–2000), near (2021–2050), and far (2071–2100) future conditions, estimating the drought spatial extent and duration, the percentage of affected area, and the frequency of drought episodes. To this end, daily ensembles of precipitation and temperature records from Global Climate Models (GCMs) and Regional Climate Models (RCMs) pairs, extracted from EURO-CORDEX and MED-CORDEX for the RCP 4.5 and 8.5 scenarios, are collected at spatial resolution of 0.11 degrees. Before the analysis, model outputs are validated on daily weather station time series, and scaling factors for possible use in bias correction are identified. Annual temperature and precipitation anomalies for near and far future conditions are investigated; drought events are identified by the standardized precipitation evapotranspiration index and standardized precipitation index at the 12-, 24-, and 36-month timescales. This study highlights the importance of using multiple drought indicators in the detection of drought events, since the comparison reveals that evapotranspiration anomaly is the main triggering factor. For both scenarios, the results indicate an intensification of droughts in northern Italy for the period 2071–2100, with the Alpine chain being especially affected by an increase of drought severity. A North-to-South spatial gradient of drought duration is also observed.