A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss
Kathrin Ohla
(1, 2, 3)
,
M.G. Veldhuizen
(4)
,
Tomer Green
(5)
,
M.E. Hannum
(6)
,
A.J. Bakke
(3)
,
S.T. Moein
(7)
,
Arnaud Tognetti
(8)
,
E.M. Postma
(9)
,
Robert Pellegrino
(6)
,
D.L.D. Hwang
(10)
,
Javier Albayay
(11)
,
Sachiko Koyama
(12)
,
A.A. Nolden
(13)
,
Thierry Thomas-Danguin
(14)
,
Veronica Pereda-Loth
(15)
,
Carla Mucignat-Caretta
(16)
,
N.S. Menger
(17)
,
Ilja Croijmans
(18)
,
Cinzia Cecchetto
,
Lina Öztürk
(4)
,
Hüseyin Yanık
,
Denis Pierron
(15)
,
Alexia Nunez-Parra
,
A.M. Martinez Pineda
,
David Gillespie
,
M.C. Farruggia
,
M.A. Fornazieri
,
Carl Philpott
,
Vera Voznessenskaya
,
K.W. Cooper
,
Paloma Rohlfs Dominguez
,
Orietta Calcinoni
,
Jasper de Groot
,
Sanne Boesveldt
,
Surabhi Bhutani
,
E.M. Weir
,
Cara Exten
,
P.V. Joseph
,
J.E. Hayes
,
M.Y. Niv
1
Helmut Schmidt University, University of the Armed Forces Hamburg
2 Firmenich Recherche et Développement
3 Penn State - Pennsylvania State University
4 Mersin University
5 HUJ - The Hebrew University of Jerusalem
6 Monell Chemical Senses Center
7 IPM - Institute for Research in Fundamental Sciences [Tehran]
8 Department of Clinical Neuroscience [Sotckholm]
9 WUR - Wageningen University and Research [Wageningen]
10 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
11 UNITN - Università degli Studi di Trento = University of Trento
12 Indiana University [Bloomington]
13 UMass Amherst - University of Massachusetts [Amherst]
14 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
15 EVOLSAN - Évolution et Santé Orale
16 Unipd - Università degli Studi di Padova = University of Padua
17 University of Tübingen
18 Universiteit Utrecht / Utrecht University [Utrecht]
2 Firmenich Recherche et Développement
3 Penn State - Pennsylvania State University
4 Mersin University
5 HUJ - The Hebrew University of Jerusalem
6 Monell Chemical Senses Center
7 IPM - Institute for Research in Fundamental Sciences [Tehran]
8 Department of Clinical Neuroscience [Sotckholm]
9 WUR - Wageningen University and Research [Wageningen]
10 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
11 UNITN - Università degli Studi di Trento = University of Trento
12 Indiana University [Bloomington]
13 UMass Amherst - University of Massachusetts [Amherst]
14 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
15 EVOLSAN - Évolution et Santé Orale
16 Unipd - Università degli Studi di Padova = University of Padua
17 University of Tübingen
18 Universiteit Utrecht / Utrecht University [Utrecht]
Arnaud Tognetti
- Fonction : Auteur
- PersonId : 792466
- IdHAL : arnaud-tognetti
- ORCID : 0000-0001-6236-3577
- IdRef : 166576387
Thierry Thomas-Danguin
- Fonction : Auteur
- PersonId : 736418
- IdHAL : thierry-thomas-danguin
- ORCID : 0000-0002-9756-355X
- IdRef : 167124501
Cinzia Cecchetto
- Fonction : Auteur
Hüseyin Yanık
- Fonction : Auteur
Alexia Nunez-Parra
- Fonction : Auteur
A.M. Martinez Pineda
- Fonction : Auteur
David Gillespie
- Fonction : Auteur
M.C. Farruggia
- Fonction : Auteur
M.A. Fornazieri
- Fonction : Auteur
Carl Philpott
- Fonction : Auteur
Vera Voznessenskaya
- Fonction : Auteur
K.W. Cooper
- Fonction : Auteur
Paloma Rohlfs Dominguez
- Fonction : Auteur
Orietta Calcinoni
- Fonction : Auteur
Jasper de Groot
- Fonction : Auteur
Sanne Boesveldt
- Fonction : Auteur
Surabhi Bhutani
- Fonction : Auteur
E.M. Weir
- Fonction : Auteur
Cara Exten
- Fonction : Auteur
P.V. Joseph
- Fonction : Auteur
J.E. Hayes
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1089157
Connectez-vous pour contacter l'auteur
Résumé
Background: Sudden smell loss is a specific early symptom of COVID-19, which, prior to the emergence of Omicron, had estimated prevalence of ~40% to 75%. Chemosensory impairments affect physical and mental health, and dietary behavior. Thus, it is critical to understand the rate and time course of smell recovery. The aim of this cohort study was to characterize smell function and recovery up to 11 months post COVID-19 infection. Methods: This longitudinal survey of individuals suffering COVID-19-related smell loss assessed disease symptoms and gustatory and olfactory function. Participants (n=12,313) who completed an initial survey (S1) about respiratory symptoms, chemosensory function and COVID-19 diagnosis between April and September 2020, were invited to complete a follow-up survey (S2). Between September 2020 and February 2021, 27.5% participants responded (n=3,386), with 1,468 being diagnosed with COVID-19 and suffering co-occurring smell and taste loss at the beginning of their illness. Results: At follow-up (median time since COVID-19 onset ~200 days), ~60% of women and ~48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered. Prevalence of parosmia and phantosmia was ~10% of participants in S1 and increased substantially in S2: ~47% for parosmia and ~25% for phantosmia. Persistent smell impairment was associated with more symptoms overall, suggesting it may be a key marker of long-COVID illness. The ability to smell during COVID-19 was rated slightly lower by those who did not eventually recover their pre-illness ability to smell at S2. Conclusions: While smell ability improves for many individuals who lost it during acute COVID-19, the prevalence of parosmia and phantosmia increases substantially over time. Olfactory dysfunction is associated with broader persistent symptoms of CO-VID-19, and may last for many months following acute COVID-19. Taste loss in the absence of smell loss is rare. Persistent qualitative smell symptoms are emerging as common long-term sequelae; more research into treatment options is strongly warranted given that even conservative estimates suggest millions of individuals may experience parosmia following COVID-19. Healthcare providers worldwide need to be prepared to treat post COVID-19 secondary effects on physical and mental health. Trial registration: This project was pre-registered at OSF 1.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss
|
Résumé |
en
Background: Sudden smell loss is a specific early symptom of COVID-19, which, prior to the emergence of Omicron, had estimated prevalence of ~40% to 75%. Chemosensory impairments affect physical and mental health, and dietary behavior. Thus, it is critical to understand the rate and time course of smell recovery. The aim of this cohort study was to characterize smell function and recovery up to 11 months post COVID-19 infection. Methods: This longitudinal survey of individuals suffering COVID-19-related smell loss assessed disease symptoms and gustatory and olfactory function. Participants (n=12,313) who completed an initial survey (S1) about respiratory symptoms, chemosensory function and COVID-19 diagnosis between April and September 2020, were invited to complete a follow-up survey (S2). Between September 2020 and February 2021, 27.5% participants responded (n=3,386), with 1,468 being diagnosed with COVID-19 and suffering co-occurring smell and taste loss at the beginning of their illness. Results: At follow-up (median time since COVID-19 onset ~200 days), ~60% of women and ~48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered. Prevalence of parosmia and phantosmia was ~10% of participants in S1 and increased substantially in S2: ~47% for parosmia and ~25% for phantosmia. Persistent smell impairment was associated with more symptoms overall, suggesting it may be a key marker of long-COVID illness. The ability to smell during COVID-19 was rated slightly lower by those who did not eventually recover their pre-illness ability to smell at S2. Conclusions: While smell ability improves for many individuals who lost it during acute COVID-19, the prevalence of parosmia and phantosmia increases substantially over time. Olfactory dysfunction is associated with broader persistent symptoms of CO-VID-19, and may last for many months following acute COVID-19. Taste loss in the absence of smell loss is rare. Persistent qualitative smell symptoms are emerging as common long-term sequelae; more research into treatment options is strongly warranted given that even conservative estimates suggest millions of individuals may experience parosmia following COVID-19. Healthcare providers worldwide need to be prepared to treat post COVID-19 secondary effects on physical and mental health. Trial registration: This project was pre-registered at OSF 1.
|
Auteur(s) |
Kathrin Ohla
1, 2, 3
, M.G. Veldhuizen
4
, Tomer Green
5
, M.E. Hannum
6
, A.J. Bakke
3
, S.T. Moein
7
, Arnaud Tognetti
8
, E.M. Postma
9
, Robert Pellegrino
6
, D.L.D. Hwang
10
, Javier Albayay
11
, Sachiko Koyama
12
, A.A. Nolden
13
, Thierry Thomas-Danguin
14
, Veronica Pereda-Loth
15
, Carla Mucignat-Caretta
16
, N.S. Menger
17
, Ilja Croijmans
18
, Cinzia Cecchetto
, Lina Öztürk
4
, Hüseyin Yanık
, Denis Pierron
15
, Alexia Nunez-Parra
, A.M. Martinez Pineda
, David Gillespie
, M.C. Farruggia
, M.A. Fornazieri
, Carl Philpott
, Vera Voznessenskaya
, K.W. Cooper
, Paloma Rohlfs Dominguez
, Orietta Calcinoni
, Jasper de Groot
, Sanne Boesveldt
, Surabhi Bhutani
, E.M. Weir
, Cara Exten
, P.V. Joseph
, J.E. Hayes
, M.Y. Niv
1
Helmut Schmidt University, University of the Armed Forces Hamburg
( 489429 )
- Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Holstenhofweg 85, 22043 Hamburg
- Allemagne
2
Firmenich Recherche et Développement
( 56555 )
- CH-1211 Genève
- Suisse
3
Penn State -
Pennsylvania State University
( 452398 )
- 201 Old Main, University Park, Pennsylvania 16802
- États-Unis
4
Mersin University
( 452872 )
- Turquie
5
HUJ -
The Hebrew University of Jerusalem
( 102986 )
- Jerusalem 91905
- Israël
6
Monell Chemical Senses Center
( 1058700 )
- 3500 Market Street, Philadelphia, PA 19104
- États-Unis
7
IPM -
Institute for Research in Fundamental Sciences [Tehran]
( 347507 )
- Niavaran Square Tehran
- Iran
8
Department of Clinical Neuroscience [Sotckholm]
( 1054838 )
- Karolinska Institutet
Department of Clinical Neuroscience
Administration
Tomtebodavägen 18A, 5th floor
171 77 Stockholm
- Suède
9
WUR -
Wageningen University and Research [Wageningen]
( 356395 )
- Droevendaalsesteeg 4, 6708 PB Wageningen
- Pays-Bas
10
UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] -
The University of Queensland
( 250752 )
- Brisbane, St Lucia, QLD 4072
- Australie
11
UNITN -
Università degli Studi di Trento = University of Trento
( 304024 )
- via Calepina, 14 - I-38122 Trento
- Italie
12
Indiana University [Bloomington]
( 300689 )
- 107 S. Indiana Avenue, Bloomington, IN 47405-7000
- États-Unis
13
UMass Amherst -
University of Massachusetts [Amherst]
( 91189 )
- 300 Massachusetts Ave, Amherst, MA 01003
- États-Unis
14
CSGA -
Centre des Sciences du Goût et de l'Alimentation [Dijon]
( 1096468 )
- Université de Bourgogne - Bât. CSG - 9E Bd Jeanne d'Arc - 21000 Dijon
- France
15
EVOLSAN -
Évolution et Santé Orale
( 1061861 )
- Toulouse
- France
16
Unipd -
Università degli Studi di Padova = University of Padua
( 301093 )
- Via 8 Febbraio 2, 35122 Padova
- Italie
17
University of Tübingen
( 461921 )
- Allemagne
18
Universiteit Utrecht / Utrecht University [Utrecht]
( 300572 )
- Heidelberglaan 8, 3584 CS Utrecht
- Pays-Bas
|
URL éditeur |
https://www.rhinologyjournal.com/Abstract.php?id=2993
|
Public visé |
Scientifique
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2022-04-10
|
Volume |
60
|
Numéro |
3
|
Page/Identifiant |
207-2017
|
Version du document |
postprint
|
Date de publication électronique |
2022-04-10
|
Sous-type de document pour les Articles |
Research article
|
Domaine(s) |
|
Thésaurus Inrae |
|
Mots-clés |
en
parosmia, phantosmia, olfaction disorders, long COVID, post-COVID, public health, smell
|
DOI | 10.4193/rhin21.415 |
Pubmed Id | 35398877 |
UT key WOS | 000886834200006 |
Origine :
Fichiers produits par l'(les) auteur(s)
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