Business model innovation (BMI) has been evolving as a burgeoning topic in acade-mia and business practice for over two decades. In recent years, knowledge produc-tion within the BMI field is accelerating at a tremendous rate, making it hard to keepup with the state of the art. Given its broad literature coverage and the systematicand reproducible process of applying statistical and quantitative techniques, the bib-liometric review can complement existing structured literature reviews by providinga holistic view of BMI research, identifying new research gaps and deriving new per-spectives to address emerging challenges. This study investigated 1032 BMI-relatedpublications from 2000 to 2021 with bibliometric techniques of citation, co-citation,bibliographic coupling and the co-occurrence of keywords analyses, aiming todevelop a theoretical framework of BMI, understand the evolutionary nuances, cap-ture emerging trends and set a future research agenda. Finally, this study advocatesthat future research could revisit the role of the BMI concept as a tool for achievingsustainable business development.