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Article dans une revue Cell Genomics Année : 2024

Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria

Rui Martiniano
Marc Haber
  • Fonction : Auteur
Mohamed Almarri
  • Fonction : Auteur
Valeria Mattiangeli
  • Fonction : Auteur
Mirte C.M. Kuijpers
  • Fonction : Auteur
Emily Breslin
  • Fonction : Auteur
Judith Littleton
  • Fonction : Auteur
Salman Almahari
  • Fonction : Auteur
Fatima Aloraifi
  • Fonction : Auteur
Daniel Bradley
  • Fonction : Auteur
Richard Durbin
  • Fonction : Auteur

Résumé

The harsh climate of Arabia has posed challenges in generating ancient DNA from the region, hindering the direct examination of ancient genomes for understanding the demographic processes that shaped Arabian populations. In this study, we report whole-genome sequence data obtained from four Tylos-period individuals from Bahrain. Their genetic ancestry can be modeled as a mixture of sources from ancient Anatolia, Levant, and Iran/Caucasus, with variation between individuals suggesting population heterogeneity in Bahrain before the onset of Islam. We identify the G6PD Mediterranean mutation associated with malaria resistance in three out of four ancient Bahraini samples and estimate that it rose in frequency in Eastern Arabia from 5 to 6 kya onward, around the time agriculture appeared in the region. Our study characterizes the genetic composition of ancient Arabians, shedding light on the population history of Bahrain and demonstrating the feasibility of studies of ancient DNA in the region.
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Dates et versions

halshs-04488151, version 1 (04-03-2024)

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Rui Martiniano, Marc Haber, Mohamed Almarri, Valeria Mattiangeli, Mirte C.M. Kuijpers, et al.. Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria. Cell Genomics, 2024, pp.100507. ⟨10.1016/j.xgen.2024.100507⟩. ⟨halshs-04488151⟩
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Dernière date de mise à jour le 20/04/2024
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