Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria
Rui Martiniano
- Fonction : Auteur
- PersonId : 1359429
- ORCID : 0000-0003-0216-778X
Marc Haber
- Fonction : Auteur
Mohamed Almarri
- Fonction : Auteur
Valeria Mattiangeli
- Fonction : Auteur
Mirte C.M. Kuijpers
- Fonction : Auteur
Emily Breslin
- Fonction : Auteur
Judith Littleton
- Fonction : Auteur
Salman Almahari
- Fonction : Auteur
Fatima Aloraifi
- Fonction : Auteur
Daniel Bradley
- Fonction : Auteur
Pierre Lombard
- Fonction : Auteur
- PersonId : 20515
- IdHAL : pierre-lombard
Richard Durbin
- Fonction : Auteur
Résumé
The harsh climate of Arabia has posed challenges in generating ancient DNA from the region, hindering the direct examination of ancient genomes for understanding the demographic processes that shaped Arabian populations. In this study, we report whole-genome sequence data obtained from four Tylos-period individuals from Bahrain. Their genetic ancestry can be modeled as a mixture of sources from ancient Anatolia, Levant, and Iran/Caucasus, with variation between individuals suggesting population heterogeneity in Bahrain before the onset of Islam. We identify the G6PD Mediterranean mutation associated with malaria resistance in three out of four ancient Bahraini samples and estimate that it rose in frequency in Eastern Arabia from 5 to 6 kya onward, around the time agriculture appeared in the region. Our study characterizes the genetic composition of ancient Arabians, shedding light on the population history of Bahrain and demonstrating the feasibility of studies of ancient DNA in the region.
Format du dépôt | Notice |
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Type de dépôt | Article dans une revue |
Titre |
en
Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria
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Résumé |
en
The harsh climate of Arabia has posed challenges in generating ancient DNA from the region, hindering the direct examination of ancient genomes for understanding the demographic processes that shaped Arabian populations. In this study, we report whole-genome sequence data obtained from four Tylos-period individuals from Bahrain. Their genetic ancestry can be modeled as a mixture of sources from ancient Anatolia, Levant, and Iran/Caucasus, with variation between individuals suggesting population heterogeneity in Bahrain before the onset of Islam. We identify the G6PD Mediterranean mutation associated with malaria resistance in three out of four ancient Bahraini samples and estimate that it rose in frequency in Eastern Arabia from 5 to 6 kya onward, around the time agriculture appeared in the region. Our study characterizes the genetic composition of ancient Arabians, shedding light on the population history of Bahrain and demonstrating the feasibility of studies of ancient DNA in the region.
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Auteur(s) |
Rui Martiniano
, Marc Haber
, Mohamed Almarri
, Valeria Mattiangeli
, Mirte C.M. Kuijpers
, Berenice Chamel
1
, Emily Breslin
, Judith Littleton
, Salman Almahari
, Fatima Aloraifi
, Daniel Bradley
, Pierre Lombard
2
, Richard Durbin
1
IFPO -
Institut Français du Proche-Orient
( 57701 )
- Ministère Des Affaires Etrangères Et Du Développement International
Rue de Damas Beyrouth
- Liban
2
Archéorient -
ARCHEORIENT - Environnements et sociétés de l'Orient ancien
( 619 )
- Maison de l'Orient et de la Méditerranée Jean-Pouilloux 7 rue Raulin 69365 LYON Cedex 07
- France
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Vulgarisation |
Non
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Comité de lecture |
Oui
|
Audience |
Internationale
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Langue du document |
Anglais
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Nom de la revue |
|
Date de publication |
2024-02
|
Page/Identifiant |
100507
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Domaine(s) |
|
DOI | 10.1016/j.xgen.2024.100507 |
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