Prospective comparison of Ga-68-DOTATATE and F-18-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases
Aurelien Archier
,
Arthur Varoquaux
(1)
,
Philippe Garrigue
(2, 3, 4)
,
Marion Montava
(5)
,
Carole Guérin
(6)
,
Sophie Gabriel
(7)
,
Eva Beschmout
,
Isabelle Morange
(8)
,
Nicolas Fakhry
,
Frederic Castinetti
(9)
,
Frédéric Sebag
(10)
,
Anne A. Barlier
(9)
,
Anderson Loundou
(11)
,
Benjamin Guillet
(2, 3, 4)
,
Karel Pacak
,
David Taieh
1
CRMBM -
Centre de résonance magnétique biologique et médicale
2 VRCM - Vascular research center of Marseille
3 CERIMED - Centre Européen de Recherche en Imagerie médicale
4 Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM]
5 Service d'ORL, CHU Nord
6 CHU Conception - Centre Hospitalier Universitaire Conception
7 IFA - Institute für arbeitsschutz deutschen gesetzlichen unfallversicherung
8 AMU - Aix Marseille Université
9 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
10 Service de chirurgie générale et endocrinienne
11 Unité d'Aide Méthodologique
2 VRCM - Vascular research center of Marseille
3 CERIMED - Centre Européen de Recherche en Imagerie médicale
4 Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM]
5 Service d'ORL, CHU Nord
6 CHU Conception - Centre Hospitalier Universitaire Conception
7 IFA - Institute für arbeitsschutz deutschen gesetzlichen unfallversicherung
8 AMU - Aix Marseille Université
9 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
10 Service de chirurgie générale et endocrinienne
11 Unité d'Aide Méthodologique
Aurelien Archier
- Fonction : Auteur
Arthur Varoquaux
- Fonction : Auteur
- PersonId : 779989
- ORCID : 0000-0002-7824-5142
- IdRef : 087700573
Philippe Garrigue
- Fonction : Auteur
- PersonId : 772257
- ORCID : 0000-0002-5712-2055
- IdRef : 171919955
Eva Beschmout
- Fonction : Auteur
Nicolas Fakhry
- Fonction : Auteur
Frederic Castinetti
- Fonction : Auteur
- PersonId : 16755
- IdHAL : frederic-castinetti
- ORCID : 0000-0002-1808-8800
- IdRef : 113296061
Anne A. Barlier
- Fonction : Auteur
- PersonId : 16684
- IdHAL : anne-barlier
- ORCID : 0000-0002-3740-6173
- IdRef : 143313339
Anderson Loundou
- Fonction : Auteur
- PersonId : 760704
- ORCID : 0000-0003-4301-9476
Karel Pacak
- Fonction : Auteur
- PersonId : 771130
- ORCID : 0000-0002-3541-3767
David Taieh
- Fonction : Auteur
Résumé
Purpose Pheochromocytomas/paragangliomas (PHEOs/PGLs) overexpress ă somatostatin receptors and recent studies have already shown excellent ă results in the localization of these tumors using Ga-68-labeled ă somatostatin analogs (Ga-68-DOTA-SSA), especially in patients with ă germline succinate dehydrogenase subunit B gene (SDHB) mutations and ă head and neck PGLs (HNPGLs). The value of Ga-68-DOTA-SSA has to be ă established in sporadic cases, including PHEOs. Thus, the aim of this ă study was to compare Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, and ă conventional imaging in patients with various PHEOs/PGLs with a special ă emphasis on sporadic cases, including those located in the adrenal ă gland. ă Design Ga-68-DOTATATE, F-18-FDOPA PET/CT, and conventional imaging ă (contrast-enhanced CT and MRI with MR angiography sequences) were ă prospectively performed in 30 patients (8 with SDHD mutations, 1 with a ă MAX mutation and 21 sporadic cases) with PHEO/PGL at initial diagnosis ă or relapse. ă Results The patient-based sensitivities were 93 % (28/30), 97 % ă (29/30), and 93 % (28/30) for Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, ă and conventional imaging, respectively. The lesion-based sensitivities ă were 93 % (43/46), 89 % (41/46), and 76 % (35/46) for Ga-68-DOTATATE ă PET/CT, F-18-FDOPA PET/CT, and conventional imaging respectively (p = ă 0.042). Ga-68-DOTATATE PET/CT detected a higher number of HNPGLs (30/30) ă than F-18-FDOPA PET/CT (26/30; p = 0.112) and conventional imaging ă (24/30; p = 0.024). Ga-68-DOTATATE PET/CT missed two PHEOs of a few ă millimeters in size and a large recurrent PHEO. One lesion was ă considered false-positive on Ga-68-DOTATATE PET/CT and corresponded to a ă typical focal lesion of fibrous dysplasia on MRI. Among the 11 lesions ă missed by conventional imaging, 7 were detected by conventional imaging ă with knowledge of the PET results (4 HNPGLs, 2 LNs, and 1 recurrent ă PHEO). ă Conclusion Ga-68-DOTATATE PET/CT is the most sensitive tool in the ă detection of HNPGLs, especially SDHD-related tumors, which may be very ă small and fail to concentrate sufficient F-18-FDOPA. The present study ă further expands the use of Ga-68-DOTATATE for all patients with HNPGLs, ă regardless of their genotype. Ga-68-DOTATATE PET/CT may be inferior to ă F-18-FDOPA PET/CT in the detection PHEOs.
Domaines
Santé publique et épidémiologie Economies et finances Psychologie Psychiatrie et santé mentaleFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Prospective comparison of Ga-68-DOTATATE and F-18-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases
|
Résumé |
en
Purpose Pheochromocytomas/paragangliomas (PHEOs/PGLs) overexpress ă somatostatin receptors and recent studies have already shown excellent ă results in the localization of these tumors using Ga-68-labeled ă somatostatin analogs (Ga-68-DOTA-SSA), especially in patients with ă germline succinate dehydrogenase subunit B gene (SDHB) mutations and ă head and neck PGLs (HNPGLs). The value of Ga-68-DOTA-SSA has to be ă established in sporadic cases, including PHEOs. Thus, the aim of this ă study was to compare Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, and ă conventional imaging in patients with various PHEOs/PGLs with a special ă emphasis on sporadic cases, including those located in the adrenal ă gland. ă Design Ga-68-DOTATATE, F-18-FDOPA PET/CT, and conventional imaging ă (contrast-enhanced CT and MRI with MR angiography sequences) were ă prospectively performed in 30 patients (8 with SDHD mutations, 1 with a ă MAX mutation and 21 sporadic cases) with PHEO/PGL at initial diagnosis ă or relapse. ă Results The patient-based sensitivities were 93 % (28/30), 97 % ă (29/30), and 93 % (28/30) for Ga-68-DOTATATE PET/CT, F-18-FDOPA PET/CT, ă and conventional imaging, respectively. The lesion-based sensitivities ă were 93 % (43/46), 89 % (41/46), and 76 % (35/46) for Ga-68-DOTATATE ă PET/CT, F-18-FDOPA PET/CT, and conventional imaging respectively (p = ă 0.042). Ga-68-DOTATATE PET/CT detected a higher number of HNPGLs (30/30) ă than F-18-FDOPA PET/CT (26/30; p = 0.112) and conventional imaging ă (24/30; p = 0.024). Ga-68-DOTATATE PET/CT missed two PHEOs of a few ă millimeters in size and a large recurrent PHEO. One lesion was ă considered false-positive on Ga-68-DOTATATE PET/CT and corresponded to a ă typical focal lesion of fibrous dysplasia on MRI. Among the 11 lesions ă missed by conventional imaging, 7 were detected by conventional imaging ă with knowledge of the PET results (4 HNPGLs, 2 LNs, and 1 recurrent ă PHEO). ă Conclusion Ga-68-DOTATATE PET/CT is the most sensitive tool in the ă detection of HNPGLs, especially SDHD-related tumors, which may be very ă small and fail to concentrate sufficient F-18-FDOPA. The present study ă further expands the use of Ga-68-DOTATATE for all patients with HNPGLs, ă regardless of their genotype. Ga-68-DOTATATE PET/CT may be inferior to ă F-18-FDOPA PET/CT in the detection PHEOs.
|
Auteur(s) |
Aurelien Archier
, Arthur Varoquaux
1
, Philippe Garrigue
2, 3, 4
, Marion Montava
5
, Carole Guérin
6
, Sophie Gabriel
7
, Eva Beschmout
, Isabelle Morange
8
, Nicolas Fakhry
, Frederic Castinetti
9
, Frédéric Sebag
10
, Anne A. Barlier
9
, Anderson Loundou
11
, Benjamin Guillet
2, 3, 4
, Karel Pacak
, David Taieh
1
CRMBM -
Centre de résonance magnétique biologique et médicale
( 480402 )
- Faculté de médecine
27 Bd Jean Moulin
13385 MARSEILLE CEDEX 05
- France
2
VRCM -
Vascular research center of Marseille
( 182181 )
- Faculté de Pharmacie, 27 bd Jean Moulin 13385 Marseille Cedex 5
- France
3
CERIMED -
Centre Européen de Recherche en Imagerie médicale
( 210090 )
- Aix-Marseille Université Faculté de Médecine Timone 27, boulevard Jean Moulin 13385 Marseille cedex 05 - France
- France
4
Service de Radiopharmacie [Hôpital de la Timone- Hôpital Nord - APHM]
( 1167814 )
- Marseille
- France
5
Service d'ORL, CHU Nord
( 388937 )
-
- France
6
CHU Conception -
Centre Hospitalier Universitaire Conception
( 509255 )
7
IFA -
Institute für arbeitsschutz deutschen gesetzlichen unfallversicherung
( 478526 )
- alte heerstrasse 111, 53757 sankt augustin
- Allemagne
8
AMU -
Aix Marseille Université
( 198056 )
- Aix-Marseille Université
Jardins du Pharo
58 Boulevard Charles Livon
13284 Marseille cedex 7
- France
9
CRN2M -
Centre de recherche en neurobiologie - neurophysiologie de Marseille
( 192792 )
- Faculté de Médecine
Secteur Nord
Boulevard Pierre Dramard
13916 MARSEILLE CEDEX 20
- France
10
Service de chirurgie générale et endocrinienne
( 155882 )
- Hôpital La Timone 264 rue Saint Pierre 13385 MARSEILLE CEDEX 05
- France
11
Unité d'Aide Méthodologique
( 233250 )
- Direction de la Recherche Clinique - 265 Chemin des Bourrely, 13015 Marseille
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2016-07
|
Volume |
43
|
Numéro |
7
|
Page/Identifiant |
1248-1257
|
Domaine(s) |
|
Mots-clés |
en
Quality
|
DOI | 10.1007/s00259-015-3268-2 |
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