Clinical and economic burden of head and neck cancer : a nationwide retrospective cohort study from France
Antoine Schernberg
(1)
,
Luis Sagaon-Teyssier
(2, 3)
,
Michaël Schwarzinger
(3, 4)
,
Sylvain Baillot
(3)
,
Mélina Bec
(5)
,
Lynda Benmahammed
(5)
,
Caroline Even
(6)
,
Lionel Geoffrois
(7)
,
Florence Huguet
(1)
,
Béatrice Le Vu
(8)
,
Laurie Lévy-Bachelot
(5)
,
Stéphane Luchini
(9)
,
Yoann Pointreau
(10)
,
Camille Robert
(5)
,
Stéphane Temam
(6)
1
CHU Tenon [AP-HP]
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 THEN - Translational Health Economics Network [Paris]
4 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
5 MSD France
6 CCF - Département de cancérologie cervico-faciale [Gustave Roussy]
7 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
8 UNICANCER
9 AMSE - Aix-Marseille Sciences Economiques
10 Centre Jean Bernard [Institut Inter-régional de Cancérologie - Le Mans]
2 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
3 THEN - Translational Health Economics Network [Paris]
4 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
5 MSD France
6 CCF - Département de cancérologie cervico-faciale [Gustave Roussy]
7 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
8 UNICANCER
9 AMSE - Aix-Marseille Sciences Economiques
10 Centre Jean Bernard [Institut Inter-régional de Cancérologie - Le Mans]
Luis Sagaon-Teyssier
- Fonction : Auteur
- PersonId : 21132
- IdHAL : luis-sagaon-teyssier
- ORCID : 0000-0001-7318-6596
Stéphane Luchini
- Fonction : Auteur
- PersonId : 742445
- IdHAL : stephane-luchini
- ORCID : 0000-0003-2721-0529
- IdRef : 059505621
Résumé
Objectives:
To evaluate the clinical and economic burden of head and neck squamous cell carcinoma (HNSCC) in France.
Methods:
All 53,255 incident adult patients discharged with a first diagnosis of HNSCC in 2010–2012 were identified from the 2008–2013 French National Hospital Discharge (PMSI) database. We conducted a retrospective longitudinal analysis of prognosis and direct costs attributable to HNSCC.
Results:
Direct medical costs attributable to HNSCC care amounted to 665 million euros in 2012 in France. The majority (62%) of incident patients were 64 years old or less at HNSCC diagnosis and incurred 1.3-fold higher mean direct costs as compared to elderly patients (41,909 vs 32,221 euros over 3 years, respectively; p<0.001). HNSCC stage at initial treatment was the major driver of mean (SD) direct costs over 3 years (p<0.001): 19,819 (23,150) euros in 31% patients diagnosed at early stage; 46,791 (34,841) euros in 60% patients diagnosed at locally advanced stage; and 43,377 (33,953) euros in 9% patients diagnosed with distant metastasis. About half patients died over 3 years at a median (IQR) age of 63 (56–75) years resulting in 10.9 years-of-life lost on average per incident patient.
Conclusion:
The present study suggests that the clinical and economic burden of HNSCC is substantial in France.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Clinical and economic burden of head and neck cancer : a nationwide retrospective cohort study from France
|
Résumé |
en
Objectives:
To evaluate the clinical and economic burden of head and neck squamous cell carcinoma (HNSCC) in France.
Methods:
All 53,255 incident adult patients discharged with a first diagnosis of HNSCC in 2010–2012 were identified from the 2008–2013 French National Hospital Discharge (PMSI) database. We conducted a retrospective longitudinal analysis of prognosis and direct costs attributable to HNSCC.
Results:
Direct medical costs attributable to HNSCC care amounted to 665 million euros in 2012 in France. The majority (62%) of incident patients were 64 years old or less at HNSCC diagnosis and incurred 1.3-fold higher mean direct costs as compared to elderly patients (41,909 vs 32,221 euros over 3 years, respectively; p<0.001). HNSCC stage at initial treatment was the major driver of mean (SD) direct costs over 3 years (p<0.001): 19,819 (23,150) euros in 31% patients diagnosed at early stage; 46,791 (34,841) euros in 60% patients diagnosed at locally advanced stage; and 43,377 (33,953) euros in 9% patients diagnosed with distant metastasis. About half patients died over 3 years at a median (IQR) age of 63 (56–75) years resulting in 10.9 years-of-life lost on average per incident patient.
Conclusion:
The present study suggests that the clinical and economic burden of HNSCC is substantial in France.
|
Auteur(s) |
Antoine Schernberg
1
, Luis Sagaon-Teyssier
2, 3
, Michaël Schwarzinger
3, 4
, Sylvain Baillot
3
, Mélina Bec
5
, Lynda Benmahammed
5
, Caroline Even
6
, Lionel Geoffrois
7
, Florence Huguet
1
, Béatrice Le Vu
8
, Laurie Lévy-Bachelot
5
, Stéphane Luchini
9
, Yoann Pointreau
10
, Camille Robert
5
, Stéphane Temam
6
1
CHU Tenon [AP-HP]
( 328304 )
- 4 Rue de la Chine, 75020 Paris
- France
2
SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD -
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
( 541536 )
- Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 05.
- France
3
THEN -
Translational Health Economics Network [Paris]
( 566221 )
- France
4
IAME (UMR_S_1137 / U1137) -
Infection, Anti-microbiens, Modélisation, Evolution
( 247341 )
- Faculté de médecine Paris Diderot Paris 7 - site Bichat - 16 rue Henri Huchard 75890 Paris Cedex 18
- France
5
MSD France
( 569919 )
- 34 Avenue Léonard de Vinci, 92400 Courbevoie
- France
6
CCF -
Département de cancérologie cervico-faciale [Gustave Roussy]
( 456739 )
- France
7
UNICANCER/ICL -
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
( 357175 )
- 6 avenue de Bourgogne, 54519 Vandoeuvre les Nancy
- France
8
UNICANCER
( 502406 )
- 101, rue de Tolbiac, 75654 Paris Cedex 13
- France
9
AMSE -
Aix-Marseille Sciences Economiques
( 526949 )
- 5-9 Boulevard Bourdet
CS 50498
13205 Marseille Cedex 1
- France
10
Centre Jean Bernard [Institut Inter-régional de Cancérologie - Le Mans]
( 353909 )
- 9, rue Beauverger - 72000 LE MANS
- France
|
Licence |
Paternité - Pas d'utilisation commerciale
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2019-07-22
|
Volume |
11
|
Page/Identifiant |
441-451
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
National Hospital discharge database, head and neck squamous cell carcinoma, prognosis, costs, burden of disease
|
DOI | 10.2147/CEOR.S198312 |
Base Horizon | fdi:010076249 |
Origine :
Publication financée par une institution
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