Distribution of killer-cell immunoglobulin-like receptor (KIR) in Comoros and Southeast France.
C. Frassati
(1)
,
M Touinssi
(2, 1)
,
C. Picard
(3, 4, 5)
,
M Segura
(6)
,
V. Galicher
(2, 1)
,
K. Papa
(1, 2)
,
K. Gagne
(1)
,
Eric Vivier
(7)
,
Anna Degioanni
(8)
,
G. Boetsch
(8)
,
Patrick Mercier
(9)
,
F. Vely
(7)
,
P de Micco
(2, 1)
,
D Reviron
,
J Chiaroni
(1, 2)
,
P Frassati
,
P Picard
(10)
,
G Galicher
,
P Papa
,
G Gagne
(11)
,
D Degioanni
,
G Böetsch
(8)
,
F Vély
(7)
1
EFS - Alpes-Méditerranée -
Etablissement Français du Sang - Alpes-Méditerranée
2 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
3 CEREDIH - Centre de Référence Déficits Immunitaires Héréditaires
4 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
5 Service d'immuno-hématologie pédiatrique [CHU Necker]
6 IMARPE - Instituto del Mar del Peru
7 CIML - Centre d'Immunologie de Marseille - Luminy
8 UAABC - Anthropologie Bio-Culturelle
9 SUPELEC-Campus Metz
10 X - École polytechnique
11 IUT Génie Biologique, Laboratoire de Biologie
2 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé
3 CEREDIH - Centre de Référence Déficits Immunitaires Héréditaires
4 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
5 Service d'immuno-hématologie pédiatrique [CHU Necker]
6 IMARPE - Instituto del Mar del Peru
7 CIML - Centre d'Immunologie de Marseille - Luminy
8 UAABC - Anthropologie Bio-Culturelle
9 SUPELEC-Campus Metz
10 X - École polytechnique
11 IUT Génie Biologique, Laboratoire de Biologie
K. Gagne
- Fonction : Auteur
- PersonId : 748409
- IdHAL : katia-gagne
- ORCID : 0000-0002-4467-5961
Eric Vivier
- Fonction : Auteur
- PersonId : 17342
- IdHAL : eric-vivier
- ORCID : 0000-0001-7022-8287
- IdRef : 076121712
Anna Degioanni
- Fonction : Auteur
- PersonId : 11841
- IdHAL : anna-degioanni
- ORCID : 0000-0002-9355-4744
- IdRef : 07723507X
D Reviron
- Fonction : Auteur
J Chiaroni
- Fonction : Auteur
- PersonId : 748906
- IdHAL : jacques-chiaroni
- ORCID : 0000-0002-3133-8990
P Frassati
- Fonction : Auteur
G Galicher
- Fonction : Auteur
P Papa
- Fonction : Auteur
D Degioanni
- Fonction : Auteur
- PersonId : 11841
- IdHAL : anna-degioanni
- ORCID : 0000-0002-9355-4744
- IdRef : 07723507X
Résumé
Killer-cell immunoglobulin-like receptors (KIRs) expressed by natural killer cells are cell surface molecules able to recognize groups of HLA class I alleles. The number and distribution of KIR genes vary among individuals and populations. The aim of this study is to analyse the KIR gene content in a Comorian population in order to investigate genetic relationships with other populations and to reconstruct past migration events. The Comorian population consisted of 54 unrelated immigrants living in France and a control population consisted of 38 individuals from Southeast France. We investigated the presence or absence of 15 KIR genes, two pseudogenes expressed and non-expressed forms of KIR2DL5 and the two major subtype full-length and deleted forms of KIR2DS4. All individuals were typed positive for the framework genes, i.e. KIR2DL4, KIR3DL2 and KIR3DL3, and the two pseudogenes KIR3DP1 and KIR2DP1. The frequencies of full-length KIR2DS4 (*00101/00102/002) were lower in the French population (F = 29%) than in the Comorian population (F = 72%) (P(c) < 0.05). No significant differences were found for other KIR genes. A total of 11 genotypes were identified in the Southeast French population and 22 genotypes in the Comorian population. The most common genotype (2DL1, 2DL3, 2DL4, 3DL1, 3DL2, 3DL3 and 2DS4) accounted for 41% in the Comorian population and 34% in the Southeast French population. Principal component analysis using KIR gene data from 20 populations was performed to determine genetic differences and relations between populations. The Comorian population exhibited closest kinship with Africans and Asians. As KIR gene content is heterogeneous among ethnic groups, it can probably be used to assess the genetic relationships among populations from different geographic areas.
Domaines
Anthropologie biologiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Distribution of killer-cell immunoglobulin-like receptor (KIR) in Comoros and Southeast France.
|
Résumé |
en
Killer-cell immunoglobulin-like receptors (KIRs) expressed by natural killer cells are cell surface molecules able to recognize groups of HLA class I alleles. The number and distribution of KIR genes vary among individuals and populations. The aim of this study is to analyse the KIR gene content in a Comorian population in order to investigate genetic relationships with other populations and to reconstruct past migration events. The Comorian population consisted of 54 unrelated immigrants living in France and a control population consisted of 38 individuals from Southeast France. We investigated the presence or absence of 15 KIR genes, two pseudogenes expressed and non-expressed forms of KIR2DL5 and the two major subtype full-length and deleted forms of KIR2DS4. All individuals were typed positive for the framework genes, i.e. KIR2DL4, KIR3DL2 and KIR3DL3, and the two pseudogenes KIR3DP1 and KIR2DP1. The frequencies of full-length KIR2DS4 (*00101/00102/002) were lower in the French population (F = 29%) than in the Comorian population (F = 72%) (P(c) < 0.05). No significant differences were found for other KIR genes. A total of 11 genotypes were identified in the Southeast French population and 22 genotypes in the Comorian population. The most common genotype (2DL1, 2DL3, 2DL4, 3DL1, 3DL2, 3DL3 and 2DS4) accounted for 41% in the Comorian population and 34% in the Southeast French population. Principal component analysis using KIR gene data from 20 populations was performed to determine genetic differences and relations between populations. The Comorian population exhibited closest kinship with Africans and Asians. As KIR gene content is heterogeneous among ethnic groups, it can probably be used to assess the genetic relationships among populations from different geographic areas.
|
Auteur(s) |
C. Frassati
1
, M Touinssi
2, 1
, C. Picard
3, 4, 5
, M Segura
6
, V. Galicher
2, 1
, K. Papa
1, 2
, K. Gagne
1
, Eric Vivier
7
, Anna Degioanni
8
, G. Boetsch
8
, Patrick Mercier
9
, F. Vely
7
, P de Micco
2, 1
, D Reviron
, J Chiaroni
1, 2
, P Frassati
, P Picard
10
, G Galicher
, P Papa
, G Gagne
11
, D Degioanni
, G Böetsch
8
, F Vély
7
1
EFS - Alpes-Méditerranée -
Etablissement Français du Sang - Alpes-Méditerranée
( 121596 )
- 149 bd Baille 13385, Marseille
- France
2
ADES -
Anthropologie bio-culturelle, Droit, Ethique et Santé
( 186857 )
- Faculté de Médecine Secteur Nord 51, Boulevard Pierre Dramard 13344 MARSEILLE CEDEX 15
- France
3
CEREDIH -
Centre de Référence Déficits Immunitaires Héréditaires
( 80990 )
- 149, rue de Sevres 75015 PARIS
- France
4
IMAGINE - U1163 -
Imagine - Institut des maladies génétiques
( 247401 )
- IHU Imagine,
156 rue de Vaugirard, 75015 PARIS
et
24 Boulevard du Montparnasse, 75015 Paris
- France
5
Service d'immuno-hématologie pédiatrique [CHU Necker]
( 19365 )
- 149 Rue de Sèvres, 75015 Paris
- France
6
IMARPE -
Instituto del Mar del Peru
( 492931 )
- Esquina Gamarra y General Valle S/N Chucuito Callao
- Pérou
7
CIML -
Centre d'Immunologie de Marseille - Luminy
( 182245 )
- Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09
- France
8
UAABC -
Anthropologie Bio-Culturelle
( 942 )
- Faculté de Médecine - Secteur Nord Batiment A - CS80011 Bd Pierre Dramard 13344 MARSEILLE Cedex 15 FRANCE
- France
9
SUPELEC-Campus Metz
( 26305 )
- 2 rue Edouard Belin 57070 Metz
- France
10
X -
École polytechnique
( 300340 )
- École polytechnique, 91128 Palaiseau Cedex
- France
11
IUT Génie Biologique, Laboratoire de Biologie
( 444478 )
- France
|
Langue du document |
Anglais
|
Date de production/écriture |
2006
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2006-05
|
Date de publication électronique |
2006-05-03
|
Volume |
67
|
Numéro |
5
|
Page/Identifiant |
356-67
|
URL éditeur |
onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.2006.00592.x/abstract;jsessionid=437A066E86E7C9D316C156CDF3E60D3A.f03t03
|
Domaine(s) |
|
Mots-clés |
en
anthropology, gene frequency, genotypes, KIR
|
DOI | 10.1111/j.1399-0039.2006.00592.x |
Pubmed Id | 16671942 |
Loading...