In vitro modulation of tracheal smooth muscle reactivity by extracts of some Senegalese medicinal plants
Mamadou Sarr
(1)
,
Fatou S. Sarr
(1, 2)
,
Doudou Diop
(3)
,
Modou Oumy Kane
(4)
,
Abdoulaye Ba
(1, 2)
,
Bocar Sarr
(1, 4)
,
Lamine Gueye
(1, 2)
,
Aminata Sall Diallo
(4)
,
Adoulaye Samb
(1, 2)
,
Ramaroson Andriantsitohaina
(5)
,
Fallou Cissé
(1, 2)
Ramaroson Andriantsitohaina
- Fonction : Auteur
- PersonId : 757970
- ORCID : 0000-0002-4770-3585
- IdRef : 074259229
Résumé
Scientific validation of pharmacological actions of 7 Senegalese plants used in traditional medicine for the treatment of respiratory illness was carried out. Changes in contractility of isolated rat trachea were assessed in organ chambers. Rings were allowed to equilibrate for 60 min before experiments were carried out, during which time the resting tension was adjusted, as required. Rings were first exposed to methanolic plants extracts (10-2 and 10-1 mg/ml) or solvent. After a 30 min incubation period, they were contracted with acetylcholine in a cumulative manner (10-9 to 10-3M). Extracts from leaves of Guiera senegalensis, Melaleuca leucodendron and Hymenocardia acida elicited a significant dosedependant inhibition of the contractile agonist, suggesting further investigations on its chemical composition, the underlying mechanisms involved and its potential health value. However, in rings preincubated with extracts from Cymbopogon giganteus leaves and Salvadora persica roots, effect of the contractile agonist was not affected. Moreover, a hypereactivity was observed with extracts from Gossypium barbadense leaves and Cassia occidentalis seeds. These results provide evidence that Senegalese herbals may be of interest as valuable source of information for the selection of plants for focussed screening programmes and for therapeutically useful products
Domaines
Anthropologie biologiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
In vitro modulation of tracheal smooth muscle reactivity by extracts of some Senegalese medicinal plants
|
Résumé |
en
Scientific validation of pharmacological actions of 7 Senegalese plants used in traditional medicine for the treatment of respiratory illness was carried out. Changes in contractility of isolated rat trachea were assessed in organ chambers. Rings were allowed to equilibrate for 60 min before experiments were carried out, during which time the resting tension was adjusted, as required. Rings were first exposed to methanolic plants extracts (10-2 and 10-1 mg/ml) or solvent. After a 30 min incubation period, they were contracted with acetylcholine in a cumulative manner (10-9 to 10-3M). Extracts from leaves of Guiera senegalensis, Melaleuca leucodendron and Hymenocardia acida elicited a significant dosedependant inhibition of the contractile agonist, suggesting further investigations on its chemical composition, the underlying mechanisms involved and its potential health value. However, in rings preincubated with extracts from Cymbopogon giganteus leaves and Salvadora persica roots, effect of the contractile agonist was not affected. Moreover, a hypereactivity was observed with extracts from Gossypium barbadense leaves and Cassia occidentalis seeds. These results provide evidence that Senegalese herbals may be of interest as valuable source of information for the selection of plants for focussed screening programmes and for therapeutically useful products
|
Auteur(s) |
Mamadou Sarr
1
, Fatou S. Sarr
1, 2
, Doudou Diop
3
, Modou Oumy Kane
4
, Abdoulaye Ba
1, 2
, Bocar Sarr
1, 4
, Lamine Gueye
1, 2
, Aminata Sall Diallo
4
, Adoulaye Samb
1, 2
, Ramaroson Andriantsitohaina
5
, Fallou Cissé
1, 2
1
ESS -
Environnement, Santé, Sociétés
( 105430 )
- France
2
Laboratoire de Physiologie et Explorations Fonctionnelles
( 166744 )
- FMPOS UCAD Bamako
- Burkina Faso
3
Laboratoire de Botanique
( 166135 )
- Institut Fondamental d'Afrique Noire Dakar Sénégal
- Sénégal
4
Laboratoire de Physiologie Pharmaceutique
( 166139 )
- Faculté de Médecine, Pharmacie, Odontologie, Dakar Sénégal
- Sénégal
5
BNVI -
Biologie Neurovasculaire Intégrée
( 11871 )
- France
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Langue du document |
Anglais
|
Nom de la revue |
|
Audience |
Non spécifiée
|
Date de publication |
2010
|
Volume |
4
|
Numéro |
1
|
Page/Identifiant |
013-018
|
Domaine(s) |
|
Mots-clés |
en
Tracheal contractility, medicinal plants, respiratory illness
|
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