Since his first lessons on the treatise On the Soul, Pietro Pomponazzi attaches much importance to Alexandrist arguments, even when he estimates that the interpretation of Aristotle given by Averroes is the best. We shall try to show that the device of the debate remains similar despite of final inflexions. It seems also that it takes up some tendencies present in late Middle Ages, despite of a new access to some texts of Alexander. The question of mortality became central, but the fundamental diagram of the possible answers is always organized around he « Christian position » and two possible interpretations of Aristotle according to the natural reason. In these discussions, besides the question of the mortality, two preoccupations come in the foreground : the question of the unity of man, and the gnoseological doctrine, mainly question of the universal knowledge