This paper investigates the reasons why entry per se is not necessarily good and the evidence showing that innovative start-ups survive longer than their non-innovative counterparts. In this framework, our own empirical analysis shows that greater survival is achieved when start-ups engage successfully in both product innovation and process innovation, with a key role of the latter. Moreover, this study goes beyond a purely microeconomic perspective and discusses the key role of the environment within which innovative entries occur. What shown and discussed in this contribution strongly supports the proposal that the creation and survival of innovative start-ups should become one qualifying point of the economic policy agenda.