Counterfactual approach with survival or time to event outcomes: An application to an exhaustive cohort of Epithelial Ovarian Carcinoma in the Rhône-Alps region of France
Marius Huguet
(1)
,
Lionel Perrier
(2, 3)
,
Olivia Bally
(2)
,
Xavier Joutard
(4)
,
Nathalie Havet
(3, 1)
,
Fadila Farsi
(5)
,
David Benayoun
(6)
,
Pierre de Saint Hilaire
(7)
,
Dominique Beal Ardisson
(8)
,
Magali Morelle
(2)
,
Isabelle Ray-Coquard
(9)
1
UL2 -
Université Lumière - Lyon 2
2 Centre Léon Bérard [Lyon]
3 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
4 GREQAM - Groupement de Recherche en Économie Quantitative d'Aix-Marseille
5 Réseau Espace Santé Cancer, Rhône-Alpes
6 Department of Radiation Oncology, Centre Hospitalier Universitaire Lyon Sud, Pierre Benite, France
7 Hopital universitaire de Lyon
8 Hôpital privé Jean Mermoz
9 Service d'Oncologie Médicale
2 Centre Léon Bérard [Lyon]
3 GATE Lyon Saint-Étienne - Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
4 GREQAM - Groupement de Recherche en Économie Quantitative d'Aix-Marseille
5 Réseau Espace Santé Cancer, Rhône-Alpes
6 Department of Radiation Oncology, Centre Hospitalier Universitaire Lyon Sud, Pierre Benite, France
7 Hopital universitaire de Lyon
8 Hôpital privé Jean Mermoz
9 Service d'Oncologie Médicale
Lionel Perrier
- Fonction : Auteur
- PersonId : 15600
- IdHAL : lionel-perrier
- ORCID : 0000-0003-4487-8723
- IdRef : 060772239
Xavier Joutard
- Fonction : Auteur
- PersonId : 13324
- IdHAL : xavier-joutard
- IdRef : 094334374
Nathalie Havet
- Fonction : Auteur
- PersonId : 17495
- IdHAL : nathalie-havet
- ORCID : 0000-0001-7454-8771
- IdRef : 069561079
Magali Morelle
- Fonction : Auteur
- PersonId : 182509
- IdHAL : magali-morelle
- ORCID : 0000-0002-4694-4918
- IdRef : 253123240
Isabelle Ray-Coquard
- Fonction : Auteur
- PersonId : 760354
- ORCID : 0000-0003-2472-8306
Résumé
Epithelial Ovarian Carcinoma (EOC) is a disease with poor prognosis, most often diagnosed at an advanced stage, thus necessitating aggres sive and complex surgery. The aim of this study was to compare Progression Free Survival (PFS) at 1st line treatment of EOC patients treated in high vs low-volume hospitals. This retrospective study using prospectively implemented databases was conducted o n an exhaustive cohort of 267 patients treated in first line during 2012 in the Rhone-Alps Region of France. In order to control for selection bias, a multivariate analysis and the Inverse Probability Weighting (IPW) using the propensity score were adopted. An Adjusted Kaplan Meier Estimator (AKME) and a univariate Cox model in the weighted sample were then applied in order to determine the impact of the centralization of care on EOC. Patients treated in lower volume hospitals had a probability of relapse (including death) that was 1.5 times higher than for patients treated in higher volume hospitals (p=0.02). As reported in other countries, the concentration of care for EOC has a significant positive impact on patient outcomes .
Domaines
Economies et financesFormat du dépôt | Fichier |
---|---|
Type de dépôt | Pré-publication, Document de travail |
Titre |
en
Counterfactual approach with survival or time to event outcomes: An application to an exhaustive cohort of Epithelial Ovarian Carcinoma in the Rhône-Alps region of France
|
Résumé |
en
Epithelial Ovarian Carcinoma (EOC) is a disease with poor prognosis, most often diagnosed at an advanced stage, thus necessitating aggres sive and complex surgery. The aim of this study was to compare Progression Free Survival (PFS) at 1st line treatment of EOC patients treated in high vs low-volume hospitals. This retrospective study using prospectively implemented databases was conducted o n an exhaustive cohort of 267 patients treated in first line during 2012 in the Rhone-Alps Region of France. In order to control for selection bias, a multivariate analysis and the Inverse Probability Weighting (IPW) using the propensity score were adopted. An Adjusted Kaplan Meier Estimator (AKME) and a univariate Cox model in the weighted sample were then applied in order to determine the impact of the centralization of care on EOC. Patients treated in lower volume hospitals had a probability of relapse (including death) that was 1.5 times higher than for patients treated in higher volume hospitals (p=0.02). As reported in other countries, the concentration of care for EOC has a significant positive impact on patient outcomes .
|
Auteur(s) |
Marius Huguet
1
, Lionel Perrier
2, 3
, Olivia Bally
2
, Xavier Joutard
4
, Nathalie Havet
3, 1
, Fadila Farsi
5
, David Benayoun
6
, Pierre de Saint Hilaire
7
, Dominique Beal Ardisson
8
, Magali Morelle
2
, Isabelle Ray-Coquard
9
1
UL2 -
Université Lumière - Lyon 2
( 33804 )
- 86, rue Pasteur - 69007 Lyon
- France
2
Centre Léon Bérard [Lyon]
( 20549 )
- 28, rue Laennec 69373 LYON Cedex 08
- France
3
GATE Lyon Saint-Étienne -
Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne
( 102550 )
- 93, chemin des Mouilles 69130 Écully
6, rue Basse des Rives 42023 Saint-Étienne cedex 02
- France
4
GREQAM -
Groupement de Recherche en Économie Quantitative d'Aix-Marseille
( 199934 )
- Centre de la Vieille Charité, 2 rue de la Charité, 13236 Marseille cedex 02
- France
5
Réseau Espace Santé Cancer, Rhône-Alpes
( 408264 )
- 60 Avenue Rockefeller
69373 LYON Cedex 08
- France
6
Department of Radiation Oncology, Centre Hospitalier Universitaire Lyon Sud, Pierre Benite, France
( 82422 )
- Centre Hospitalier Lyon Sud, 69495, Pierre-Bénite cedex
- France
7
Hopital universitaire de Lyon
( 450584 )
- France
8
Hôpital privé Jean Mermoz
( 358778 )
-
- France
9
Service d'Oncologie Médicale
( 219424 )
- 28 rue Laennec 69008 Lyon
- France
|
Langue du document |
Anglais
|
Date de production/écriture |
2016
|
Domaine(s) |
|
Mots-clés (JEL) |
|
Référence interne |
|
Mots-clés |
en
T Counterfactual, Disease management programme, France, Epithelial Ovarian Cancer, Propensity score, Centralization of care
|
Origine :
Fichiers produits par l'(les) auteur(s)
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