This communication presents the benefit of holistic approaches of work analysis in ergonomics and professional didactics in the field of occupational training. The research-intervention processes discussed have the originality aiming to conduct jointly learning questions, conditions of training and prevention of occupational risks. Its specificities are presented from three research-interventions in the field of aeronautics industry, agriculture and education. We stress questions that are emerging, such as the design of digital tools for training, the importance of subjective commitment at work and the identity transformations and we precise how the holistic approach advocated, based on a model of operator development that articulates mastery of tasks and work and the construction of health and safety over the long term, may be used to treat these questions.