This paper attempts to construct a general framework which could serve as a common ground for the different studies trying to combine the new form of knowledge creation with the formation of high-skilled scientific and technical workers (academics, scientists and engineers). In this domain, complex interactions between higher education and research system, education/scientific policy agencies and firms play a crucial role in determining the functioning of labours markets and shaping its structure. It is one of reasons why we need both to combine its analysis with the general dynamics of innovation and to insert it into a global picture of the institutional configuration of R/D. Within such context, we will tentatively describe both the nature of new space of innovation and the dynamics of high skill/knowledge creation