Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer
Lidia Delrieu
- Fonction : Auteur
- PersonId : 783628
- ORCID : 0000-0003-1240-5390
Marina Touillaud
- Fonction : Auteur
- PersonId : 780565
- ORCID : 0000-0001-9900-5861
Olivia Pérol
- Fonction : Auteur
- PersonId : 782321
- ORCID : 0000-0002-7543-7050
Agnès Martin
- Fonction : Auteur
- PersonId : 801413
- ORCID : 0000-0003-0297-1823
- IdRef : 255073097
Magali Morelle
- Fonction : Auteur
- PersonId : 182509
- IdHAL : magali-morelle
- ORCID : 0000-0002-4694-4918
- IdRef : 253123240
Christine Friedenreich
- Fonction : Auteur
- PersonId : 804579
- ORCID : 0000-0002-4783-1966
- IdRef : 149329563
Pauline Mury
- Fonction : Auteur
- PersonId : 791971
- ORCID : 0000-0001-5202-7078
- IdRef : 230281222
Armelle Dufresne
- Fonction : Auteur
- PersonId : 762479
- ORCID : 0000-0002-6637-3526
Thomas Bachelot
- Fonction : Auteur
- PersonId : 757054
- ORCID : 0000-0002-0866-9484
- IdRef : 088209970
Pierre-Etienne Heudel
- Fonction : Auteur
- PersonId : 792988
- ORCID : 0000-0002-8555-8921
Béatrice Fervers
- Fonction : Auteur
- PersonId : 969134
- ORCID : 0000-0003-3498-6499
Olivier Trédan
- Fonction : Auteur
- PersonId : 767637
- ORCID : 0000-0001-5881-9383
Vincent Pialoux
- Fonction : Auteur
- PersonId : 1098190
- ORCID : 0000-0003-2057-061X
Résumé
Purpose. Regular physical activity (PA) can affect oxidative stress, known to be involved in carcinogenesis. The objective of this study was to evaluate the associations between a six-month PA intervention and oxidative stress biomarkers, PA, and clinical outcomes in patients with metastatic breast cancer. Methods. Forty-nine newly diagnosed patients with metastatic breast cancer were recruited for a single-arm, unsupervised, and personalized six-month walking intervention with activity tracker. PA level and PA fitness, plasma concentrations of DNA oxidation (8OhdG), lipid peroxidation (MDA), and protein oxidation (AOPP), plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase, plasma and leucocyte activities of myeloperoxidase (MPO) and NADPH oxidase (NOX), and clinical markers of tumor progression (RECIST criteria) were measured at baseline and after the six-month intervention. Results. GPX activity (+17%) and MDA (+9%) significantly increased between baseline and the end of the intervention. Changes in PA level and fitness were significantly positively correlated with changes in plasma GPX and significantly negatively with changes in NOX in the leucocytes. Plasma MDA was significantly higher (+20%) whereas plasma AOPP was lower (-46%) for patients with tumor progression or that died during the six months as compared to patients without progression. Conclusion. A six-month PA intervention may be potentially beneficial in metastatic breast cancer patients for enhancing antioxidant enzyme activity and decreasing prooxidant enzyme activity. Moreover, AOPP and MDA could also be favorable and unfavorable biomarkers, respectively, since they are associated with disease progression and fitness level in this population. This trial is registered with NCT number: NCT03148886.
Domaines
Sciences de l'Homme et SociétéFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer
|
Résumé |
en
Purpose. Regular physical activity (PA) can affect oxidative stress, known to be involved in carcinogenesis. The objective of this study was to evaluate the associations between a six-month PA intervention and oxidative stress biomarkers, PA, and clinical outcomes in patients with metastatic breast cancer. Methods. Forty-nine newly diagnosed patients with metastatic breast cancer were recruited for a single-arm, unsupervised, and personalized six-month walking intervention with activity tracker. PA level and PA fitness, plasma concentrations of DNA oxidation (8OhdG), lipid peroxidation (MDA), and protein oxidation (AOPP), plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase, plasma and leucocyte activities of myeloperoxidase (MPO) and NADPH oxidase (NOX), and clinical markers of tumor progression (RECIST criteria) were measured at baseline and after the six-month intervention. Results. GPX activity (+17%) and MDA (+9%) significantly increased between baseline and the end of the intervention. Changes in PA level and fitness were significantly positively correlated with changes in plasma GPX and significantly negatively with changes in NOX in the leucocytes. Plasma MDA was significantly higher (+20%) whereas plasma AOPP was lower (-46%) for patients with tumor progression or that died during the six months as compared to patients without progression. Conclusion. A six-month PA intervention may be potentially beneficial in metastatic breast cancer patients for enhancing antioxidant enzyme activity and decreasing prooxidant enzyme activity. Moreover, AOPP and MDA could also be favorable and unfavorable biomarkers, respectively, since they are associated with disease progression and fitness level in this population. This trial is registered with NCT number: NCT03148886.
|
Auteur(s) |
Lidia Delrieu
, Marina Touillaud
, Olivia Pérol
, Agnès Martin
, Magali Morelle
1
, Christine Friedenreich
, Pauline Mury
, Armelle Dufresne
, Thomas Bachelot
, Pierre-Etienne Heudel
, Béatrice Fervers
, Olivier Trédan
, Vincent Pialoux
1
GATE -
Health System Analysis Laboratory
( 199519 )
- Université de Lyon - Ecully
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2021-07-16
|
Volume |
2021
|
Page/Identifiant |
1-9
|
Domaine(s) |
|
DOI | 10.1155/2021/6694594 |
PubMed Central | PMC8302399 |
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