Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer - HAL Accéder directement au contenu
Article dans une revue Oxidative Medicine and Cellular Longevity Année : 2021

Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer

Lidia Delrieu
Marina Touillaud
Olivia Pérol
Agnès Martin
Christine Friedenreich
Pauline Mury
Armelle Dufresne
Thomas Bachelot
Pierre-Etienne Heudel
Béatrice Fervers
Olivier Trédan
Vincent Pialoux

Résumé

Purpose. Regular physical activity (PA) can affect oxidative stress, known to be involved in carcinogenesis. The objective of this study was to evaluate the associations between a six-month PA intervention and oxidative stress biomarkers, PA, and clinical outcomes in patients with metastatic breast cancer. Methods. Forty-nine newly diagnosed patients with metastatic breast cancer were recruited for a single-arm, unsupervised, and personalized six-month walking intervention with activity tracker. PA level and PA fitness, plasma concentrations of DNA oxidation (8OhdG), lipid peroxidation (MDA), and protein oxidation (AOPP), plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase, plasma and leucocyte activities of myeloperoxidase (MPO) and NADPH oxidase (NOX), and clinical markers of tumor progression (RECIST criteria) were measured at baseline and after the six-month intervention. Results. GPX activity (+17%) and MDA (+9%) significantly increased between baseline and the end of the intervention. Changes in PA level and fitness were significantly positively correlated with changes in plasma GPX and significantly negatively with changes in NOX in the leucocytes. Plasma MDA was significantly higher (+20%) whereas plasma AOPP was lower (-46%) for patients with tumor progression or that died during the six months as compared to patients without progression. Conclusion. A six-month PA intervention may be potentially beneficial in metastatic breast cancer patients for enhancing antioxidant enzyme activity and decreasing prooxidant enzyme activity. Moreover, AOPP and MDA could also be favorable and unfavorable biomarkers, respectively, since they are associated with disease progression and fitness level in this population. This trial is registered with NCT number: NCT03148886.
Loading...

Dates et versions

halshs-03432612, version 1 (17-11-2021)

Identifiants

Citer

Lidia Delrieu, Marina Touillaud, Olivia Pérol, Agnès Martin, Magali Morelle, et al.. Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer. Oxidative Medicine and Cellular Longevity, 2021, 2021, pp.1-9. ⟨10.1155/2021/6694594⟩. ⟨halshs-03432612⟩
10 Consultations
0 Téléchargements
Dernière date de mise à jour le 21/04/2024
comment ces indicateurs sont-ils produits

Altmetric

Partager

Gmail Facebook Twitter LinkedIn Plus