Mining conflicts are among the most widespread issues linked to natural resources development and management in mineral-rich countries. Guinea mining industries development presents a huge challenge in promoting integrated, prosperous, peaceful, and sustainable mining. The scramble of companies to exploit bauxite in the Boké region is correlated with a wave of protests and violent conflicts. This article explores the reasons for the resurgence of conflicts in the Guinea Republic, proposes some strategies for better mining conflicts prevention, management in Boke region. Thus, through a survey carried out in 7 Municipalities of the region and other mining localities of the country, we use a quantitative approach through descriptive statistic elements to identify the causes of the outburst of the conflict in Boke which seriously hinders the climate of socioeconomic activities for local development. The outcomes of this study reveal that youth employment, water and electricity supply, the weakness in the management of compensation mechanism are the main reasons for conflict escalation in Boke. Although, solutions proposed by the state and some NGOs appear to be hopeful. However, better management of public services and good governance based on more innovative public-private partnerships, and changes in government policy to better benefit the local communities could solve these problems holistically. The implementation of a better strategy (approach) in the management of relations with the surrounding communities by considering the depths and the sociohistorical, cultural, economic characteristics of the region would guarantee an environment of peaceful cohabitation between the local communities and the companies.