While entrepreneurial ecosystem research has attracted increasing attention in the scholarly literature, research focusing on its structure beyond geographical borders is limited. The aim of this paper is to examine the configuration of the entrepreneurial ecosystem and propose an original model by implementing an international perspective. Specifically, this study combines the following two theoretical streams: the entrepreneurial ecosystem and the international context. An empirical investigation was performed through an exploratory study of key public and private French internationalization support organizations. The findings provide new insights related to 4 axes, i.e., structural, systemic, evolutionary and spatial axes, which are enhanced by the adopted international perspective. This perspective is connected to a glo-cal culture that combines both adaptation to local specificities and global integration. The findings also underline the importance of sub-ecosystem interactions in establishing a consistent and effective long-term entrepreneurial development strategy in a territory. This research provides useful implications for both theory and practice, especially for policymakers and support organizations.