Article Dans Une Revue PLoS ONE Année : 2011

High Throughput, Multiplexed Pathogen Detection Authenticates Plague Waves in Medieval Venice, Italy

Résumé

Background: Historical records suggest that multiple burial sites from the 14th-16(th) centuries in Venice, Italy, were used during the Black Death and subsequent plague epidemics. Methodology/Principal Findings: High throughput, multiplexed real-time PCR detected DNA of seven highly transmissible pathogens in 173 dental pulp specimens collected from 46 graves. Bartonella quintana DNA was identified in five (2.9%) samples, including three from the 16th century and two from the 15th century, and Yersinia pestis DNA was detected in three (1.7%) samples, including two from the 14th century and one from the 16th century. Partial glpD gene sequencing indicated that the detected Y. pestis was the Orientalis biotype. Conclusions: These data document for the first time successive plague epidemics in the medieval European city where quarantine was first instituted in the 14th century.

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halshs-00738244 , version 1 (03-10-2018)

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Thi-Nguyen-Ny Tran, Michel Signoli, Luigi Fozzati, Gérard Aboudharam, Didier Raoult, et al.. High Throughput, Multiplexed Pathogen Detection Authenticates Plague Waves in Medieval Venice, Italy. PLoS ONE, 2011, 6 (3), pp.e16735. ⟨10.1371/journal.pone.0016735⟩. ⟨halshs-00738244⟩
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