Influence of Intention to Adhere, Beliefs and Satisfaction About Medicines on Adherence in Solid Organ Transplant Recipients
Amélie Hugon
(1)
,
Matthieu Roustit
(2)
,
Audrey Lehmann
(1)
,
Christel Saint-Raymond
(3)
,
Elisabeth Borrel
(4)
,
Marie-Noëlle Hilleret
(5)
,
Paolo Malvezzi
(6)
,
Pierrick Bedouch
(7)
,
Pascal Pansu
(8)
,
Benoit Allenet
(7)
1
UGA UFRP -
Université Grenoble Alpes - UFR Pharmacie
2 CIC - Grenoble
3 Public Hospital Medical Service
4 Département de cardiologie [CHU de Grenoble]
5 Département de Gastroentérologie et hépatologie
6 CHU-Grenoble - Département de Diabétologie, Urologie, Néphrologie et Endocrinologie
7 TIMC-IMAG-ThEMAS - Techniques pour l'Evaluation et la Modélisation des Actions de la Santé
8 LSE - Laboratoire des Sciences de l'Éducation (Grenoble)
2 CIC - Grenoble
3 Public Hospital Medical Service
4 Département de cardiologie [CHU de Grenoble]
5 Département de Gastroentérologie et hépatologie
6 CHU-Grenoble - Département de Diabétologie, Urologie, Néphrologie et Endocrinologie
7 TIMC-IMAG-ThEMAS - Techniques pour l'Evaluation et la Modélisation des Actions de la Santé
8 LSE - Laboratoire des Sciences de l'Éducation (Grenoble)
Pierrick Bedouch
- Fonction : Auteur
- PersonId : 859134
Pascal Pansu
- Fonction : Auteur
- PersonId : 1165278
- IdHAL : pascal-pansu
- ORCID : 0000-0002-8344-615X
Benoit Allenet
- Fonction : Auteur
- PersonId : 949812
Résumé
Introduction Nonadherence to immunosuppressive (IS) therapy is associated with poor outcomes. Identifying factors predicting poor adherence is therefore essential. The primary objective of this study was to test whether parameters of a model adapted from the theory of planned behavior, and more specifically attitudes that are influenced by beliefs and satisfaction with medication, could predict adherence in solid organ transplant patients.
Methods Adherence was assessed with a self-reported medication adherence scale and IS blood trough concentrations over 6 months, in four transplant units. Satisfaction and beliefs were assessed using the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) and Beliefs about Medicines Questionnaire (BMQ), respectively. Theory of planned behavior was assessed with a specific questionnaire exploring intentions, subjective norms, attitudes and perceived behavioral control. Treatment characteristics and socioeconomic data were also collected.
Results One hundred and fifty-three solid organ transplant patients were enrolled, including lung (n=33), heart (n=43), liver (n=42), and kidney (n=44) patients. Satisfaction and positive beliefs about medication were higher in adherent than those in nonadherent patients. Factors independently associated with an increased risk of nonadherence were negative general beliefs about medications (odds ratio [OR]=0.89 [0.83–0.97]), living alone (OR=2.78 [1.09–7.09]), heart transplantation (OR=3.49 [1.34–9.09]), and being on everolimus (OR=5.02 [1.21–20.8]).
Conclusion Negative beliefs toward medications were shown to be an independent risk factor of poor adherence. Therefore, the BMQ could be an effective, easy to implement tool, for use in everyday practice, to identify patients needing interventions to improve adherence to IS.
Domaines
Sciences de l'Homme et SociétéFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Introduction Nonadherence to immunosuppressive (IS) therapy is associated with poor outcomes. Identifying factors predicting poor adherence is therefore essential. The primary objective of this study was to test whether parameters of a model adapted from the theory of planned behavior, and more specifically attitudes that are influenced by beliefs and satisfaction with medication, could predict adherence in solid organ transplant patients.
Methods Adherence was assessed with a self-reported medication adherence scale and IS blood trough concentrations over 6 months, in four transplant units. Satisfaction and beliefs were assessed using the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) and Beliefs about Medicines Questionnaire (BMQ), respectively. Theory of planned behavior was assessed with a specific questionnaire exploring intentions, subjective norms, attitudes and perceived behavioral control. Treatment characteristics and socioeconomic data were also collected.
Results One hundred and fifty-three solid organ transplant patients were enrolled, including lung (n=33), heart (n=43), liver (n=42), and kidney (n=44) patients. Satisfaction and positive beliefs about medication were higher in adherent than those in nonadherent patients. Factors independently associated with an increased risk of nonadherence were negative general beliefs about medications (odds ratio [OR]=0.89 [0.83–0.97]), living alone (OR=2.78 [1.09–7.09]), heart transplantation (OR=3.49 [1.34–9.09]), and being on everolimus (OR=5.02 [1.21–20.8]).
Conclusion Negative beliefs toward medications were shown to be an independent risk factor of poor adherence. Therefore, the BMQ could be an effective, easy to implement tool, for use in everyday practice, to identify patients needing interventions to improve adherence to IS.
|
Titre |
en
Influence of Intention to Adhere, Beliefs and Satisfaction About Medicines on Adherence in Solid Organ Transplant Recipients
|
Auteur(s) |
Amélie Hugon
1
, Matthieu Roustit
2
, Audrey Lehmann
1
, Christel Saint-Raymond
3
, Elisabeth Borrel
4
, Marie-Noëlle Hilleret
5
, Paolo Malvezzi
6
, Pierrick Bedouch
7
, Pascal Pansu
8
, Benoit Allenet
7
1
UGA UFRP -
Université Grenoble Alpes - UFR Pharmacie
( 144104 )
- Domaine de la Merci - 38706 La Tronche cedex
- France
2
CIC - Grenoble
( 2603 )
- Centre Hospitalier Universitaire LYON 38043 GRENOBLE CEDEX 9
- France
3
Public Hospital Medical Service
( 102525 )
- Antananarivo
- Madagascar
4
Département de cardiologie [CHU de Grenoble]
( 530068 )
- CHU de Grenoble
Avenue Maquis du Grésivaudan
38700 La Tronche
- France
5
Département de Gastroentérologie et hépatologie
( 34738 )
- France
6
CHU-Grenoble -
Département de Diabétologie, Urologie, Néphrologie et Endocrinologie
( 83904 )
- Hôpital Michallon CHU-Grenoble 38700 La Tronche
- France
7
TIMC-IMAG-ThEMAS -
Techniques pour l'Evaluation et la Modélisation des Actions de la Santé
( 388317 )
- Domaine de la Merci, 38706 La Tronche
- France
8
LSE -
Laboratoire des Sciences de l'Éducation (Grenoble)
( 123645 )
- UFR SHS - BSHM - 1251 avenue Centrale - Domaine Universitaire - 38400 Saint-Martin d'Hères
- France
|
Page/Identifiant |
222 - 228
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2014
|
Volume |
98
|
Numéro |
2
|
Domaine(s) |
|
DOI | 10.1097/TP.0000000000000221 |
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